Materials and methods for modifying the activity of T cells
This disclosure provides miRNA/mRNA pairs that can be used to increase the efficacy of T cells or to down-modulate T cell efficacy and restore equilibrium.
1. A method of increasing the survival, stability and/or function of Treg cells, comprising
providing Treg cells from an individual;
contacting the Treg cells with an miRNA-146b antagomir that inhibits miRNA-146b; and
introducing the contacted Treg cells back into the individual.
2. The method of claim 1 , wherein the Treg cells are contacted with the moiety on day 0.
3. The method of claim 1 , wherein the Treg cells are cultured for about 1 to about 21 days before being contacted with the moiety.
4. The method of claim 1 , wherein the Treg cells are contacted with the moiety for several hours to several days to several weeks.
5. The method of claim 1 , wherein the Treg cells are tTreg cells or iTreg cells.