ULTRASOUND TRANSDUCER AND ARRAY FOR INTRAVASCULAR THROMBOLYSIS
A catheter-implemented transducer device for intravascular thrombolysis, is described herein. Such a transducer device includes a catheter defining a longitudinal axis and having opposed proximal and distal ends. At least one ultrasonic transducer arrangement is disposed about the distal end. The ultrasonic transducer arrangement is oriented with acoustic waves propagating parallel or perpendicular to the longitudinal axis. Optionally, the ultrasonic transducer arrangement is configured as a multi-layer stacked structure of ultrasonic transducer elements. Optionally, the ultrasonic transducer arrangement is a laser ultrasonic transducer arrangement. Optionally, the ultrasonic transducer arrangement is configured to operate in a lateral mode.
1 . A catheter-implemented transducer device for intravascular thrombolysis, comprising:
a catheter defining a longitudinal axis and having opposed proximal and distal ends; and
at least one ultrasonic transducer arrangement disposed about the distal end, wherein the at least one ultrasonic transducer arrangement is configured as a multi-layer stacked structure of ultrasonic transducer elements.
2 . The device of claim 1 , wherein the at least one ultrasonic transducer arrangement emits low-frequency ultrasonic energy within a frequency range of between less than 1 MHz and about 3 MHz.
3 . The device of claim 1 , wherein the at least one ultrasonic transducer arrangement emits ultrasonic waves that propagate parallel or perpendicular to the longitudinal axis.
4 . The device of claim 1 , wherein the at least one ultrasonic transducer arrangement is configured to operate in a lateral or longitudinal mode.
5 . The device of claim 1 , wherein the at least one ultrasonic transducer arrangement includes a plurality of ultrasonic transducer elements arranged about a circumference of the distal end of the catheter, each of the plurality of ultrasonic transducer elements being oriented parallel to the longitudinal axis.
6 . The device of claim 1 , further comprising at least two ultrasonic transducer arrangements disposed about the distal end of the catheter.
7 . The device of claim 6 , wherein the at least two ultrasonic transducer arrangements operate in a lateral or longitudinal mode to cooperate to generate pressure capable of inducing cavitation about the distal end of the catheter.
8 . The device of claim 1 , further comprising an acoustic lens arranged adjacent to and outwardly of the at least one ultrasonic transducer arrangement, the acoustic lens being configured to obtain a focused acoustic field generated by the at least one ultrasonic transducer arrangement.
9 . The device of claim 1 , further comprising a laser-generated focused ultrasound (LGFU) lens disposed about the distal end of the catheter and oriented perpendicularly to the longitudinal axis with acoustic waves propagating parallel to the longitudinal axis.
10 . The device of claim 9 , wherein the LGFU lens is arranged to share a focal point with the at least one ultrasonic transducer arrangement.
11 . The device of claim 1 , further comprising a supply conduit arranged along the catheter, the supply conduit being configured to supply at least one of droplets, microbubbles, or a pharmaceutical compound outwardly of the at least one ultrasonic transducer arrangement from the distal end of the catheter.
12 . A catheter-implemented transducer device for intravascular thrombolysis, comprising:
a catheter defining a longitudinal axis and having opposed proximal and distal ends; and
at least one laser ultrasonic transducer arrangement disposed about the distal end.
13 . The device of claim 12 , wherein the at least one laser ultrasonic transducer arrangement comprises a laser-generated focused ultrasound (LGFU) lens disposed about the distal end and oriented perpendicularly to the longitudinal axis with acoustic waves propagating parallel to the longitudinal axis.
14 . The device of claim 13 , wherein the LGFU lens is arranged to share a focal point with the at least one laser ultrasonic transducer arrangement.
15 . The device of claim 13 , wherein the LGFU lens is configured as a plano or a concave optical lens coated with a laser ultrasound transduction layer.
16 . The device of claim 13 , further comprising a micro-optical fiber or fiber bundle that extends along the longitudinal axis of the catheter and into operable engagement with the LGFU lens.
17 . The device of claim 16 , wherein the micro-optical fiber or fiber bundle is configured to direct laser light to and through the LGFU lens, the laser light directed through the LGFU lens interacting with the laser ultrasound transduction layer thereof to photoacoustically convert the laser light to ultrasonic energy, the converted ultrasonic energy cooperating with ultrasonic energy emitted by an ultrasonic transducer arrangement to induce cavitation about the distal end of the catheter.
18 . The device of claim 12 , further comprising a supply conduit arranged along the catheter, the supply conduit being configured to supply at least one of droplets, microbubbles, or a pharmaceutical compound outwardly of the at least one laser ultrasonic transducer arrangement from the distal end of the catheter.
19 - 46 . (canceled)
47 . A catheter-implemented transducer device for intravascular thrombolysis, comprising:
a catheter defining a longitudinal axis and having opposed proximal and distal ends; and
at least one ultrasonic transducer arrangement disposed about the distal end, wherein the at least one ultrasonic transducer arrangement is configured to operate in a lateral mode.
48 . The device of claim 47 , wherein the at least one ultrasonic transducer arrangement emits low-frequency ultrasonic energy within a frequency range of between less than 1 MHz and about 3 MHz.
49 - 57 . (canceled)