Biomimetic mechanical tension driven fabrication of nanofibrillar architecture
This present disclosure provides methods for utilizing such forces in when generating nanofibrillar constructs with engineered morphology from the nano- to macro-scales. Using for example, a biopolymer silk fibroin as a base material, patterns an intermediate hydrogel were generated within a deformable mold. Subsequently, mechanical tension was introduced via either hydrogel contraction or mold deformation, and finally a material is reentrapped in this transformed shape via beta-sheet crystallization and critical point drying. Topdown engineered anchorages, cables, and shapes act in concert to mediate precision changes in nanofiber alignment/orientation and a macroscale form of provided nanofibrillar structure. An ability of this technique to engineer large gradients of nano- and micro-scale order, manipulate mechanical properties (such as plasticity and thermal transport), and the in-situ generation of 2D and 3D, multi-tiered and doped, nanofibrillar constructs was demonstrated.
1. An article of manufacture, comprising:
a nanofibrillar architecture, comprising: a fibrillar or fibrous material that is or comprises silk;
wherein the nanofibrillar architecture further comprises at least one additive, agent, and/or functional moiety, wherein the nanofibrillar architecture is crystalline, wherein the nanofibrillar architecture has a structure formed under a force and/or tension, wherein a comparison nanofibrillar architecture that is not crystalline and otherwise identical to the nanofibrillar architecture would be unable to maintain the structure by itself, and wherein the nanofibrillar architecture is characterized by birefringence.
2. The article of manufacture of claim 1 , wherein the nanofibrillar architecture is two-dimensional.
3. The article of manufacture of claim 1 , wherein the nanofibrillar architecture is three-dimensional.
4. The article of manufacture of claim 1 , wherein the at least one additive, agent, and/or functional moiety is distributed throughout the nanofibrillar architecture.
5. The article of manufacture of claim 1 , wherein the at least one additive, agent, and/or functional moiety is uniformly distributed throughout the nanofibrillar architecture.
6. The article of manufacture of claim 1 , wherein the at least one additive, agent, and/or functional moiety is non-uniformly distributed throughout the nanofibrillar architecture.
7. The article of manufacture of claim 1 , wherein the at least one additive, agent, and/or functional moiety is coated on a surface of the nanofibrillar architecture.
8. The article of manufacture of claim 1 , wherein the nanofibrillar architecture forms a metashape.
9. The article of manufacture of claim 8 , wherein the metashape is or comprises triangular, hexagonal, and trihexagonal cells.
10. The article of manufacture of claim 1 , wherein fibrils of the nanofibrillar architectures are aligned.
11. The article of manufacture of claim 1 , wherein the article further comprises anchorages, cables, or shapes.