Trim proteins and galectins cooperate and codirect autophagy and are useful in the treatment of autophagy related diseases
Tie present invention relates to compositions and methods of influencing autophagy by modulating TRIM (tripartite motif containing) proteins, especially TRIM 8, TRIM: 10, TRIM 16, TRIM 19 and/or TRIM 51 (preferably TRIM 16} and galectins, especially galectins 3 m order to influence autophagy and treat a number of disease states and/or conditions which are mediated and/or influenced by autophagy, including inflammatory disease states and/or conditions, including a microbial infection such as a Mycobacterium infection, among numerous others, an inflammatory disorder, a lysosomal, storage disorder, an immune disorder, a neurodegenerative disorder and a cancer.
1. A method of treating a Mycobacterium tuberculosis infection in a patient or subject in need comprising administering to said patient or subject an effective amount of TRIM 16 protein and at least one galectin selected from the group consisting of galectin 3, galectin 8 and galectin 9.
2. The method according to claim 1 wherein said galectin is galectin 3.
3. The method according to claim 1 wherein said galectin is galectin 8.
4. The method according to claim 1 wherein said galectin is galectin 9.
5. The method according to claim 1 wherein said galectin is a mixture of galectin 3 and galectin 8.
6. The method according to claim 1 wherein said galectin is a mixture of galectin 3 and galectin 9.
7. The method according to claim 1 wherein said galectin is a mixture of galectin 8 and galectin 9.
8. The method according to claim 1 wherein said galectin is a mixture of galectin 3, galectin 8 and galectin 9.
9. The method according to claim 1 wherein said TRIM 16 protein and said galectin(s) are administered to said patient or subject by parenteral administration.
10. The method according to claim 1 wherein said TRIM 16 protein and said galectin(s) are administered to said patient or subject by intravenous administration.
11. The method according to claim 1 wherein said TRIM 16 protein and said galectin(s) are administered to said patient or subject by intramuscular administration.
12. The method according to claim 1 wherein said TRIM 16 protein and said galectin(s) are administered to said patient or subject by topical administration.
13. The method according to claim 1 wherein said TRIM 16 protein and said galectin(s) are administered to said patient or subject by transdermal administration.
14. The method according to claim 1 wherein said TRIM 16 protein is administered to said patient or subject by parenteral, transdermal or topical administration and said galectin(s) are administered to said patient or subject by parenteral, transdermal or topical administration.
15. A method of treating tuberculosis in a patient or subject in need comprising administering to a patient or subject in need an effective amount of a composition comprising an effective amount of a TRIM 16 protein and at least one galectin selected from the group consisting of galectin 3, galectin 8 and galectin 9.
16. The method according to claim 15 wherein said galectin is galectin 3.
17. The method according to claim 15 wherein said galectin is galectin 8.
18. The method according to claim 15 wherein said galectin is galectin 9.
19. The method according to claim 15 wherein said composition is administered to said patient or subject by parenteral administration.
20. The method according to claim 15 wherein said composition is administered to said patient or subject by transdermal or topical administration.