IP Library Granted Patent US 11,389,095
Granted Patent B2
US 11,389,095 · App. 16/321,798 · Granted Jul 19, 2022

Integrated fiber optic sensor umbilical catheter

Inventors: Virender Rehan (Torrance, CA); Jesus Delgado (Torrance, CA)
Assignees: Los Angeles BioMedical Research Institute at Harbor UCLA Medical Center; Intelligent Optical Systems
A61B5/14557A61B5/01A61B5/1459A61B5/14552A61B5/6852A61B5/14539A61B5/150038A61B5/4839A61B2503/045A61B2505/03A61B2562/0233A61B2562/0271
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Quick Facts
Patent No.
US 11,389,095
App. No.
16/321,798
Granted
Jul 19, 2022
Kind
B2
Abstract

Embodiments described herein relate to a catheter configured to detect at least one blood gas parameter present in blood in an artery of a patient, including, but not limited to, a catheter wall forming at least one lumen configured for umbilical arterial catheterization, at least one optical fiber incorporated in the catheter wall, wherein the at least one optical fiber is configured to detected the at least one blood gas parameter.

Claims (67)

1. A catheter for a system configured to detect at least one blood gas parameter present in blood in an artery of a patient, the catheter comprising:

a catheter wall forming at least one lumen configured for umbilical arterial catheterization, the catheter wall forming a plurality of channels, each channel being open on a side of the catheter wall along at least a portion of a length dimension of catheter; and

at least one optical fiber in each channel of the catheter wall; and

a permeable membrane covering the open side of the catheter wall and each optical fiber;

wherein at least one blood gas parameter sensor is included in each optical fiber and is configured to sense the at least one blood gas parameter; and

wherein the at least one optical fiber comprises a plurality of optical fibers in each of the channels, including at least two optical fibers tuned for respectively different blood gas parameters in each of the channels.

2. The catheter of claim 1 , wherein:

the at least one lumen is formed in an interior surface of the catheter wall; and

each optical fiber is incorporated in the catheter wall.

3. The catheter of claim 1 , wherein:

the at least one lumen is two or more lumens; and

each of the at least one lumen is formed in an interior surface of the catheter wall.

4. The catheter of claim 1 , wherein each of the at least one lumen is configured to perform one of blood pressure monitoring, arterial blood sampling, blood transfusion, or nutrition infusion.

5. The catheter of claim 1 , wherein:

each of the optical fibers is embedded in one of the channels.

6. The catheter of claim 1 , wherein the at least one blood gas parameter comprises one or more of PaO 2 , PaCO 2 , bicarbonate, pH, or temperature.

7. The catheter of claim 1 , wherein:

each of the optical fibers has a sensitive segment;

a plurality of blood gas parameter sensors are arranged on the sensitive segment; and

each of the plurality of blood gas parameter sensors on each optical fiber is configured to detect one of the at least one blood gas parameter.

8. The catheter of claim 7 , wherein each of the plurality of blood gas parameter sensors is a luminescent optical fiber chemical sensor tuned to the one of the at least one blood gas parameter.

9. The catheter of claim 1 , wherein the plurality of optical fibers comprises:

a first optical fiber having a first plurality of blood gas parameter sensors configured to detect a first blood gas parameter of the at least one blood gas parameter; and

a second optical fiber having a second plurality of blood gas parameter sensors configured to detect a second blood gas parameter of the at least one blood gas parameter.

10. The catheter of claim 1 , wherein the plurality of optical fibers comprises:

two O 2 -sensing optical fibers each having a plurality of blood gas parameter sensors configured to detect PaO 2 ;

a CO 2 -sensing optical fiber having a plurality of blood gas parameter sensors configured to detect PaCO 2 ; and

a pH-sensing optical fiber having a plurality of blood gas parameter sensors configured to detect pH.

11. The catheter of claim 10 , wherein the catheter further comprises a thermocouple incorporated in the catheter wall configured to detect temperature in the blood of the artery.

12. The catheter of claim 1 , wherein:

each channel formed by the catheter wall forms at least one sensorized lumen on an exterior surface of the catheter wall; and

each of the optical fibers is embedded in a respective one of the at least one sensorized lumen.

13. The catheter of claim 1 , wherein:

each channel formed by the catheter wall forms at least one sensorized lumen on an exterior surface of the catheter wall; and

the plurality of optical fibers comprises two or more optical fibers embedded in one of the at least one sensorized lumen.

14. The catheter of claim 1 , wherein:

the plurality of optical fibers comprises a first optical fiber configured to detect a first blood gas parameter of the at least one blood gas parameter and a second optical fiber configured to detect the first blood gas parameter; and

the first optical fiber and second optical fiber are located on opposite sides of a cross-section of the catheter relative to a diameter of the cross-section.

15. The catheter of claim 14 , wherein the first optical fiber and the second optical fiber are symmetrically located in the cross-section relative to the diameter of the cross-section.

16. The catheter of claim 1 , wherein each optical fiber is configured to remain in the artery for continuously detecting the at least one blood gas parameter.

17. The catheter of claim 1 , wherein:

the plurality of channels comprises a first channel and a second channel;

the plurality of optical fibers comprises at least one optical fiber in the first channel having at least one sensor tuned for the same blood gas parameter as at least one sensor of at least one of optical fiber in the second channel.

18. A method for making a catheter configured to detect at least one blood gas parameter present in blood in an artery of a patient, the method comprising:

providing a catheter wall having at least one lumen configured for umbilical arterial catheterization, and a plurality of channels, each channel being open on a side of the catheter wall along at least a portion of a length dimension of catheter;

providing at least one optical fiber in each channel of the catheter wall;

covering the open side of the catheter wall and each optical fiber with a permeable membrane; and

providing at least one blood gas parameter sensor in each optical fiber, wherein the at least one blood gas parameter sensor is configured to sense the at least one blood gas parameter;

wherein providing the at least one optical fiber comprises providing a plurality of optical fibers in each of the channels, including at least two optical fibers tuned for respectively different blood gas parameters in each of the channels.

19. The catheter of claim 18 , wherein:

the plurality of channels comprises a first channel and a second channel;

at least one of the optical fibers in the first channel has at least one sensor tuned for the same blood gas parameter as at least one sensor of at least one of the optical fibers in the second channel.

20. A method for measuring one or more blood gas parameters, comprising:

inserting, into an artery of a patient, a catheter having a catheter wall forming a plurality of channels, each channel being open on a side of the catheter wall along at least a portion of a length dimension of catheter, at least one optical fiber in each channel of the catheter wall of the catheter, and a permeable membrane covering the open side of the catheter wall and each optical fiber, wherein a plurality of blood gas parameter sensors are arranged on a sensitive segment of the optical fiber;

determining a sensed output from each of the plurality of blood gas parameter sensors for a blood gas parameter for blood present in the artery; and

combining the sensed output from each of the plurality of blood gas parameter sensors into a single output;

wherein the at least one optical fiber comprises a plurality of optical fibers in each of the channels, including at least two optical fibers tuned for respectively different blood gas parameters in each of the channels.

21. The method of claim 20 , wherein each of the plurality of blood gas parameter sensors is a luminescent optical fiber chemical sensor having a chemically-sensitive material sensitive to a blood gas associated with one of the one or more blood gas parameters.

22. The method of claim 20 , wherein the one or more blood gas parameters is one of PaO 2 , PaCO 2 , bicarbonate, pH, or temperature.

23. The method of claim 20 , wherein:

the catheter has at least one additional optical fiber integrated into the catheter wall;

a plurality of blood gas parameter sensors are arranged on a sensitive segment of each of the at least one additional optical fiber; and

the plurality of blood gas parameter sensors of each of the at least one additional optical fiber are sensitive to another blood gas parameter.

24. The method of claim 20 , wherein:

the catheter has at least one additional optical fiber integrated into the catheter wall;

a plurality of blood gas parameter sensors are arranged on a sensitive segment of each of the at least one additional optical fiber; and

the plurality of blood gas parameter sensors of each of the at least one additional optical fiber are sensitive to the same blood gas parameter.

Assignments (3)
CONFIRMATORY LICENSE Recorded Aug 5, 2020
From: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 053402/0382 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 6, 2019
From: DELGADO, JESUS
To: INTELLIGENT OPTICAL SYSTEMS
Reel/Frame 049089/0851 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 6, 2019
From: REHAN, VIRENDER
To: LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR UCLA MEDICAL CENTER
Reel/Frame 049090/0107 →
Continuity (2)
Provisional Application 62368951 · Jul 29, 2016
Related Publication 20210282680A1 · Sep 16, 2021