Compositions and methods for adhesion to surfaces
Provided herein are compositions and their methods of use to adhere (e.g., in wet and dry environments) a variety of materials together.
1. An adhesive composition comprising:
(i) a multivalent metal salt selected from one of a tetracalcium phosphate or tricalcium phosphate;
(ii) an aqueous medium;
(iii) citric acid or malonic acid;
(iv) calcium citrate;
(v) phosphoserine;
wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa.
2. The composition of claim 1 , wherein the aqueous medium is water.
3. The composition of claim 1 , wherein the phosphoserine is present in an amount from about 10% to about 90% weight by weight (w/w) of the total composition.
4. The composition of claim 1 , wherein the composition has a mean particle size of less than 1.000 mm.
5. The composition of claim 1 , wherein the composition has a tacky state for up to 12 minutes after mixing with the aqueous medium.
6. The composition of claim 5 , wherein the composition during the tacky state has a tack stress of between about 10 kPa and about 250 kPa after mixing with the aqueous medium.
7. The composition of claim 1 , wherein the composition has a putty state for up to 15 minutes after mixing with the aqueous medium.
8. The composition of claim 7 , wherein the composition during the putty state has a tack stress of between about 10 kPa and about 250 kPa after mixing with the aqueous medium.
9. The composition of claim 1 , further comprising an additive.
10. The composition of claim 9 , wherein the additive comprises a salt, a filler, a viscosity modifier, an antibiotic, or a medication.
11. A kit comprising an adhesive composition comprising:
(i) a multivalent metal salt selected from one of tetracalcium phosphate or tricalcium phosphate;
(ii) an aqueous medium;
(iii) citric acid or malonic acid;
(iv) calcium citrate;
(v) phosphoserine;
wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa.
12. The kit of claim 11 , comprising a device for application of the adhesive composition.
13. The kit of claim 11 , comprising a device for preparation of the adhesive composition.
14. A method of filling a bone void resulting from the removal of a bone cyst, granuloma, abscess, or similar bone defect, wherein bone void is crestal, central, or lateral to the alveolar ridge or another portion of the facial skeleton, the method comprising:
a) preparing an adhesive composition comprising:
(i) a multivalent metal salt selected from one of tetracalcium phosphate or tricalcium phosphate;
(ii) an aqueous medium;
(iii) citric acid or malonic acid;
(iv) calcium citrate;
(v) phosphoserine;
wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa;
and
b) placing the composition into said bone void;
wherein the composition hardens and/or cures in less than about 30 minutes.
15. The method of claim 14 , wherein the composition is allowed to remain undisturbed until resorption of the composition by the bone occurs.
16. A method of filling a bone void resulting from a prepared extraction site, the method comprising:
a) preparing an adhesive composition comprising:
(i) a multivalent metal salt selected from one of tetracalcium phosphate or tricalcium phosphate;
(ii) an aqueous medium;
(iii) citric acid or malonic acid;
(iv) calcium citrate;
(v) phosphoserine;
wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa
and
b) placing the composition into said bone void;
wherein the composition hardens and/or cures in less than about 30 minutes.
17. A method of filling a gap or discontinuity of bone resulting from a congenital condition, trauma, inappropriate healing, a resection of bone, or a procedure involving cutting or segmentation of bone in order to change its size, shape, or contour, the method comprising:
a) preparing an adhesive composition comprising:
(i) a multivalent metal salt selected from one of tetracalcium phosphate or tricalcium phosphate;
(ii) an aqueous medium;
(iii) citric acid or malonic acid;
(iv) calcium citrate;
(v) phosphoserine;
wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa
and
b) placing the composition into said gap or discontinuity;
wherein the composition hardens and/or cures in less than about 30 minutes.
18. The method of claim 17 , wherein the composition is allowed to remain undisturbed until resorption of the composition by the bone occurs.
19. A method of repairing a defect in a tooth, the method comprising:
a) preparing an adhesive composition comprising:
(i) a multivalent metal salt selected from one of tetracalcium phosphate or tricalcium phosphate;
(ii) an aqueous medium;
(iii) citric acid or malonic acid;
(iv) calcium citrate;
(v) phosphoserine;
wherein the adhesive strength of the adhesive composition upon curing is greater than 1,000 kPa; and
b) placing the composition into or onto said tooth;
wherein the composition hardens and/or cures in less than about 30 minutes.