TIME RELEASE OF FAT-SOLUBLE ACTIVES
Compositions include an extended release fat-soluble active composition. In certain aspects, the extended release fat-soluble active composition includes an extended release bead multiparticulate comprising a fat-soluble active. In other aspects, the extended release fat-soluble active composition includes an extended release lipid multiparticulate comprising a fat-soluble active.
1 . An extended release fat-soluble active composition comprising:
extended release beads comprising a fat-soluble active, the extended release beads configured to release greater than 80% of the fat-soluble active over a period of 4 hours or more.
2 . The extended release fat-soluble active composition of claim 1 , wherein the fat-soluble active comprises at least one of a fat-soluble vitamin, a carotenoid, a cannabinoid, a polyunsaturated fatty acid, or combinations thereof.
3 . The extended release fat-soluble active composition of claim 2 , wherein the cannabinoid is selected from the group consisting of a cannabinol, a cannabidiol, a tetrahydrocannabinol, and/or a combination thereof.
4 . The extended release fat-soluble active composition of claim 1 , wherein the extended release beads comprise an inert core and a nutrient layer coating the inert core, wherein the nutrient layer comprises the fat-soluble active.
5 . The extended release fat-soluble active composition of claim 4 , wherein the nutrient layer comprises one or more vitamins and/or minerals.
6 . The extended release fat-soluble active composition of claim 4 , wherein the nutrient layer comprises a performance enhancing supplement.
7 . The extended release fat-soluble active composition of claim 4 , wherein the extended release beads further comprise a seal film layer, wherein the seal film layer comprises a sealer and the seal film layer coats the nutrient layer.
8 . The extended release fat-soluble active composition of claim 1 , wherein the extended release beads further comprise a barrier coating layer.
9 . The extended release fat-soluble active composition of claim 1 , wherein the extended release beads further comprise one or more swellable polymers.
10 - 11 . (canceled)
12 . The extended release fat-soluble active composition of claim 1 , wherein the particle size of extended release beads is from about 400 μm to about 1700 μm.
13 . The extended release fat-soluble active composition of claim 1 , wherein the particle size of extended release beads is from about 800 p.m to about 1250 μm.
14 . The extended release fat-soluble active composition of claim 1 , wherein the extended release beads further comprise a binder.
15 . The extended release fat-soluble active composition of claim 14 , wherein the nutritional layer of the extended release beads further comprises a binder.
16 . The extended release fat-soluble active composition of claim 1 , wherein the inert core of the extended release beads comprises at least one of celluloses, starches, saccharides, or mixtures thereof.
17 . (canceled)
18 . The extended release fat-soluble active composition f claim 1 further comprising a performance enhancing supplement, wherein the performance enhancing supplement comprises at least one of a vitamin, a mineral, protein, creatine, an amino acid, a carbohydrate, a fatty acid, a stimulant, pyruvate, black pepper extract, and a citric acid cycle intermediate.
19 . The extended release fat-soluble active composition of claim 1 , wherein the composition further comprises an immediate release oil phase, wherein the extended release beads are incorporated into the oil phase.
20 . (canceled)
21 . The extended release fat-soluble active composition of claim 19 , wherein the immediate release oil phase comprises one or more edible oils.
22 . The extended release fat-soluble active composition of claim 19 , wherein the oil phase comprises one or more vitamins and/or minerals and/or a performance enhancing supplement.
23 . An extended release fat-soluble active composition comprising:
extended release lipid multiparticulates comprising a fat-soluble active and a lipid matrix, the lipid matrix configured to release 80% or more of the fat-soluble active over a period of 4 hours or more, and optionally one or more vitamins and/or minerals and a performance enhancing supplement.
24 - 37 . (canceled)
38 . The extended release fat-soluble active composition of claim 1 , wherein the composition is in the form of a liquid capsule.