Conjugate of minoxidil and peptide
The present invention relates to a composition for preventing hair loss and, more specifically, to a compound having a structure in which Minoxidil and a peptide are chemically connected, and to a pharmaceutical composition or cosmetic composition for preventing hair loss or promoting hair growth comprising the compound. The compound having a structure in which Minoxidil and a peptide are chemically connected according to the present invention has not only excellent physiological activity such as hair loss reduction, hair growth promotion or cell growth promotion, but also excellent stability in water, and can therefore be useful as a composition for preventing hair loss and promoting hair growth.
1. A compound represented by the following structure:
wherein the peptide is a water-soluble peptide that is 5 to 20 amino acids in length and has a ratio of hydrophilic side chain-containing amino acid of no less than 70%, and
wherein the hydrophilic side chain-containing amino acid is selected from the group consisting of arginine (Arg), histidine (His), lysine (Lys), asparaginic acid (Asp), glutamic acid (Glu), serine (Ser), threonine (Thr), asparagine (Asn), glutamine (Gln), cysteine (Cys), selenocysteine (Sec), glycine (Gly) and proline (Pro).
2. The compound according to claim 1 , wherein the peptide is 8 to 15 amino acids in length.
3. The compound according to claim 1 , wherein the water-soluble peptide has a ratio of hydrophilic side chain-containing amino acids of no less than 90%.
4. The compound according to claim 1 , wherein the water-soluble peptide has 5 or less hydrophobic side chain-containing amino acids, and the hydrophobic side chain-containing amino acid is selected from the group consisting of alanine (Ala), valine (Val), isoleucine (Ile), leucine (Leu), methionine (Met), phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp).
5. The compound according to claim 4 , wherein the water-soluble peptide has 3 or less hydrophobic side chain-containing amino acids.
6. The compound according to claim 1 , wherein the peptide is selected from the group consisting of nokkin peptide consisting of the amino acid sequence of SEQ ID NO: 1; keramin2 peptide consisting of the amino acid sequence of SEQ ID NO: 2; and WINT peptide consisting of the amino acid sequence of SEQ ID NO: 3.
7. A pharmaceutical composition for hair loss treatment or hair growth promotion comprising the compound of claim 1 .
8. A cosmetic composition for hair loss treatment or hair growth promotion comprising the compound of claim 1 .
9. The cosmetic composition according to claim 8 , wherein the cosmetic composition is a formulation selected from the group consisting of emollient beauty wash, nutrition beauty wash, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray, powder, hair tonic, hair cream, hair lotion, hair shampoo, hair rinse, hair conditioner, hair-spray, hair air-sol, pomade, sol-gel, emulsion, oil, wax and air-sol.
10. A method for treating hair loss or promoting hair growth comprising the step of transdermally administering the compound of claim 1 to the affected part of the individual suffering from hair loss.