Cancer treatment using CX26 blocking peptides
Blocking peptides that inhibit FAK or NANOG binding to Cx26, and a method of treating cancer by administering these blocking peptides to a subject in need thereof are described.
1. A peptide having a size of 50 amino acids or less comprising a fragment of Cx26 comprising an amino acid sequence having at least 95% identity and only conservative substitutions to SEQ ID NO: 3 or SEQ ID NO: 5 and a protein transduction domain.
2. The peptide of claim 1 , wherein the peptide comprises an amino acid sequence, having at least 95% identity and only conservative substitutions to SEQ ID NO: 3.
3. The peptide of claim 1 , wherein the peptide comprises an amino acid sequence having at least 95% identity and only conservative substitutions to SEQ ID NO: 5.
4. The peptide of claim 1 , wherein the protein transduction domain is derived from Antennapedia.
5. The peptide of claim 3 , wherein the peptide comprises an amino acid sequence having at least 6 amino acids selected from the group consisting of SEQ ID NO: 20 and SEQ ID NO: 21.
6. A method of treating triple negative breast cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a peptide of claim 1 .