IP Library Granted Patent US 12,209,235
Granted Patent B2
US 12,209,235 · App. 16/328,431 · Granted Jan 28, 2025

Detection of foam levels

Inventors: Klaus Gebauer (Uppsala, SE); Pierre Le Greves (Uppsala, SE); Andrew David Pris (Niskayuna, NY); Jozsef Vasi (Uppsala, SE); Sam Petrocelli (Old Tappan, NJ); Hanno Ehring (Uppsala, SE); Esmaeil Heidari (Niskayuna, NY); Ali Can (Niskayuna, NY)
Assignee: CYTIVA SWEDEN AB
C12M41/02C12M23/14C12M23/22C12M31/02C12M31/10C12M41/06C12M41/48
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Quick Facts
Patent No.
US 12,209,235
App. No.
16/328,431
Granted
Jan 28, 2025
Kind
B2
Abstract

A device and method for detecting the level of foam in a reactor vessel monitors the intensity of the light or the movement of the light detected by a camera which monitors at least one light source positioned inside the reactor vessel or viewable through the reactor vessel.

Claims (32)

1. A method, comprising the steps of:

a) providing a reactor vessel with at least one light source which may be monitored to indicate the height level of any liquid and/or any foam inside the reactor vessel;

b) providing at least one camera or light detector positioned to monitor said at least one light source;

c) monitoring the intensity of light detected by the camera or light detector from said at least one light source; and

d) from the intensity of light detected, determining a height level of a foam layer in the reactor vessel, a thickness of the foam layer and a rate of change of the thickness of the foam layer inside the reactor vessel.

2. The method of claim 1 , wherein either the light detector(s) or the at least one light source, or both, are capable of providing spatial resolution.

3. The method of claim 1 , wherein said at least one light detector comprises at least one camera.

4. The method of claim 1 , wherein said at least one light source comprises a set of vertically spaced light sources, such as wherein light sources are arranged in a column or array along an inner wall of the reactor vessel.

5. The method of claim 4 , wherein the vertically spaced light sources are arranged in a vertical line along an inner wall of the reactor vessel.

6. The method of claim 5 , wherein the light sources are arranged in a staggered or oblique line along an inner wall of the reactor vessel.

7. The method of claim 1 , wherein the light sources are individually addressable.

8. The method of claim 1 , wherein the light sources are LEDs.

9. The method of claim 1 , wherein the light sources emit visible light or near infrared radiation.

10. The method of claim 4 , wherein the at least one camera or light detector collects scattered and/or reflected light from the vertically spaced light sources and wherein a computer which controls the light sources, processes data from the camera or light detector to measure the foam layer height level, the thickness of the foam layer and the rate of change of the thickness of the foam layer in the reactor vessel.

11. The method of claim 10 , wherein in step c) each light source is triggered independently and said camera or light detector collects a series of images or light intensity data from triggered light sources at different heights.

12. The method of claim 11 , wherein in step c) the light intensity is measured over at least one region of interest (ROI) of each image obtained from a camera, where the ROI comprises the position of a triggered light source.

13. The method of claim 12 , where the ROI comprises an area of at least 10 times the cross section area of the triggered light source, such as at least 100 times the cross section area.

14. The method of claim 12 , wherein in step c) the images are transformed to a coordinate system in a plane or volume comprising the triggered light sources.

15. A method, comprising the steps of;

i) determining a height level of a foam layer in a reactor vessel, a thickness of the foam layer and a rate of change of the thickness of the foam layer;

ii) calculating a suitable amount and/or an addition rate of an antifoam agent to add to the reactor vessel to defoam the foam layer, the amount and/or the addition rate of the antifoam agent calculated as a function of the determined height level of the foam layer, the thickness of the foam layer and the rate of change of thickness of the foam layer; and

iii) adding said amount, optionally at said addition rate to said reactor vessel.

16. The method of claim 15 , further comprising, after step iii), a repetition of step i) and, if needed, a repetition of steps ii) and iii).

17. The method of claim 16 , wherein steps i)-iii) are repeated until the height level of the foam layer, the thickness of the foam layer and the rate of change of thickness of the foam layer has reached a predetermined level.

18. The method of claim 15 , wherein the calculation in step ii) is performed using a stored calibration function.

19. The method of claim 1 , further comprising ascertaining foam morphology information from the intensity of light detected, the foam morphology information including density of the foam layer, bubble size of bubbles in the foam layer, and a presence of particulates in the foam layer.

20. The method of claim 1 , further comprising:

predicting an amount of a defoaming agent that will lower the foam layer in the reactor vessel as a function of the height level of the foam layer, the thickness of the foam layer and the rate of change of the thickness of the foam layer;

applying the predicted amount of defoaming agent to the reactor vessel;

monitoring the rate of change of the thickness of the foam layer in response to applying the predicted amount of the defoaming agent to the reactor vessel; and

changing the amount of the defoaming agent that is applied to the reactor vessel in accordance with the monitored rate of change of the thickness of the foam layer.

21. The method of claim 1 , wherein the providing of the at least one camera or light detector comprises placing a first camera or light detector about a top region of the reactor vessel and a second camera or light detector about a side wall of the reactor vessel.

Assignments (2)
CHANGE OF NAME Recorded Oct 6, 2020
From: GE HEALTHCARE BIO-SCIENCES AB
To: CYTIVA SWEDEN AB
Reel/Frame 053992/0640 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 26, 2019
From: GEBAUER, KLAUS; LE GREVES, PIERRE; PRIS, ANDREW DAVID; VASI, JOZSEF; PETROCELLI, SAM; EHRING, HANNO; HEIDARI, ESMAEIL; CAN, ALI
To: GE HEALTHCARE BIO-SCIENCES AB
Reel/Frame 048442/0436 →
Priority Claims (1)
GB 1614717 · Aug 31, 2016 · national
Continuity (1)
Related Publication 20210123010A1 · Apr 29, 2021
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