IP Library Granted Patent US 11,131,682
Granted Patent B2
US 11,131,682 · App. 16/331,603 · Granted Sep 28, 2021

Automatic analyzer

Inventors: Masaki Hara (Tokyo, JP); Tetsuji Kawahara (Tokyo, JP); Hiroyuki Takayama (Tokyo, JP)
Assignee: HITACHI HIGH-TECH CORPORATION
G01N35/10G01N1/14G01N35/025
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Quick Facts
Patent No.
US 11,131,682
App. No.
16/331,603
Granted
Sep 28, 2021
Kind
B2
Abstract

The automatic analyzer includes a gear pump that supplies cleaning water to reagent probes and sample probes; a cleaning flow path that feeds the cleaning water discharged from the gear pump to the respective probes; a pressure sensor that measures pressure of the cleaning flow path; a return flow path that is disposed in parallel to the gear pump and connects a discharging port side of the gear pump and an aspirating port side thereof; a throttling unit that is disposed in the return flow path and adjusts a flow rate of the cleaning water flowing through the return flow path; and a control unit that changes an opening and closing degree of the throttling unit according to a measurement result of the pressure sensor. Accordingly, it is unnecessary to control driving of a pump used for cleaning a probe while having a low cost and a small mounting size.

Claims (37)

1. An automatic analyzer configured to dispense a sample and a reagent into a reaction container for reaction with each other and measures the reacted liquid, comprising:

a dispensing probe configured to dispense the reagent and the sample into the reaction container;

a gear pump configured to supply cleaning water to the dispensing probe;

a cleaning flow path configured to feed the cleaning water discharged from the gear pump up to the dispensing probe;

a pressure sensor configured to measure pressure of the cleaning flow path;

a return flow path which is disposed in parallel to the gear pump and connects a discharging port side of the gear pump and an aspirating port side thereof;

a flow rate adjustment unit which is disposed in the return flow path and is configured to adjust a flow rate of the cleaning water flowing through the return flow path; and

a control unit configured to adjust the flow rate of the cleaning water flowing through the return flow path by changing an opening and closing degree of the flow rate adjustment unit according to a measurement result of the pressure sensor.

2. The automatic analyzer according to claim 1 , wherein

the control unit is further configured to compare an adjustment target pressure with a pressure value of the cleaning flow path measured by the pressure sensor, and, when the pressure value is different from the adjustment target pressure, perform control to change the opening and closing degree of the flow rate adjustment unit so that the pressure of the cleaning flow path becomes the adjustment target pressure.

3. The automatic analyzer according to claim 2 , wherein

the control unit is further configured to change the flow rate adjustment unit in an opening direction when the cleaning flow path has higher pressure than the adjustment target pressure, and change the flow rate adjustment unit in a closing direction when the cleaning flow path has lower pressure than the adjustment target pressure.

4. The automatic analyzer according to claim 3 , wherein

the flow rate adjustment unit is a proportional solenoid valve, and

the control unit is further configured to limit an opening and closing direction of the proportional solenoid valve to one direction and perform adjustment of the opening and closing degree in multiple stages when adjusting the cleaning flow path to the adjustment target pressure.

5. The automatic analyzer according to claim 4 , wherein

the control unit is further configured to adjust the proportional solenoid valve in multiple stages only in the closing direction.

6. The automatic analyzer according to claim 3 , wherein

the flow rate adjustment unit is a proportional solenoid valve, and

the control unit is configured to record a transition of a control value for driving the proportional solenoid valve and determine a life span of the gear pump.

7. The automatic analyzer according to claim 3 , wherein

the flow rate adjustment unit is a proportional solenoid valve, and

the control unit is further configured to perform PI control so that an overshoot allowable value of the proportional solenoid valve does not exceed the adjustment target pressure of the cleaning flow path.

8. The automatic analyzer according to claim 1 , further comprising:

a branch pipe configured to branch the cleaning flow path to each of the dispensing probes; and

a probe pressure sensor configured to measure pressure of the cleaning water discharged from the dispensing probe, wherein

the control unit is further configured to determine abnormality of the cleaning flow path based upon a difference between a measured value of the pressure sensor and a measured value of the probe pressure sensor.

9. The automatic analyzer according to claim 8 , further comprising:

a filter which is provided in the branch pipe to eliminate a foreign substance in the cleaning water, wherein

the control unit is further configured to determine a clogging state of the filter as the abnormality.

10. The automatic analyzer according to claim 1 , further comprising:

a water storage unit for storing the cleaning water; and

a pump configured to supply the cleaning water stored in the water storage unit to the gear pump;

wherein the return flow path is connected to the aspirating port side of the gear pump between the pump and the gear pump.

11. The automatic analyzer according to claim 1 , further comprising:

a water storage unit configured to store the cleaning water; and

an opening and closing valve provided in the cleaning flow path and configured to return the cleaning water to the water storage unit.

Assignments (2)
CHANGE OF NAME AND ADDRESS Recorded Mar 30, 2020
From: HITACHI HIGH-TECHNOLOGIES CORPORATION
To: HITACHI HIGH-TECH CORPORATION
Reel/Frame 052259/0227 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 8, 2019
From: HARA, MASAKI; KAWAHARA, TETSUJI; TAKAYAMA, HIROYUKI
To: HITACHI HIGH-TECHNOLOGIES CORPORATION
Reel/Frame 048540/0303 →