Disc therapy
A method is provided that includes providing an electrode, which includes a wire that has a wire diameter of between 75 and 125 microns. The wire includes a non-electrically-insulated current-application longitudinal segment, which, in the absence of any applied forces, is coiled and has a mean pitch of between 1.1 and 2 times the wire diameter, and an entire longitudinal length of between 5 and 35 mm. The wire also includes an electrically-insulated lead longitudinal segment has an entire longitudinal length of between 5 and 80 mm, in the absence of any applied forces. At least a portion of the electrode is implanted in a body of a subject. Other embodiments are also described.
1. A method comprising:
providing an electrode, which includes a wire that (a) has a wire diameter of between 75 and 125 microns and (b) includes:
(i) a non-electrically-insulated current-application longitudinal segment, which, in the absence of any applied forces, is coiled and has (A) a mean pitch of between 1.1 and 2 times the wire diameter, and (B) an entire longitudinal length of between 5 and 35 mm, and
(ii) an electrically-insulated lead longitudinal segment has an entire longitudinal length of between 5 and 80 mm, in the absence of any applied forces; and
implanting at least a portion of the electrode in a body of a subject.
2. The method according to claim 1 , wherein the mean pitch of the current-application longitudinal segment is between 1.2 and 1.8 times the wire diameter, in the absence of any applied forces.
3. The method according to claim 1 , wherein the current-application longitudinal segment has an outer coil diameter of between 3 and 7 times the wire diameter, in the absence of any applied forces.
4. The method according to claim 1 , wherein the current-application longitudinal segment has an outer coil diameter of between 400 and 600 microns, in the absence of any applied forces.
5. The method according to claim 1 , wherein the entire longitudinal length of the current-application longitudinal segment is between 10 and 25 mm, in the absence of any applied forces.
6. The method according to claim 1 , wherein the entire longitudinal length of the electrically-insulated lead longitudinal segment is between 10 and 50 mm, in the absence of any applied forces.
7. The method according to claim 1 , wherein the current-application longitudinal segment extends to a distal end of the wire.
8. The method according to claim 1 , wherein the electrically-insulated lead longitudinal segment is coated with parylene.
9. The method according to claim 1 , wherein the lead longitudinal segment is not coiled, in the absence of any applied forces.
10. The method according to claim 1 , wherein the lead longitudinal segment is coiled, in the absence of any applied forces.
11. The method according to claim 1 , wherein implanting the at least a portion of the electrode comprises implanting the at least a portion of the electrode such that:
the current-application longitudinal segment is disposed at least partially in an intervertebral disc of the subject, and
at least a portion of the lead longitudinal segment is disposed in the body of the subject outside the intervertebral disc.
12. The method according to claim 11 , wherein implanting the at least a portion of the electrode comprises implanting the at least a portion of the electrode such that the current-application longitudinal segment is disposed entirely in the intervertebral disc.
13. The method according to claim 12 , wherein implanting the at least a portion of the electrode comprises implanting the at least a portion of the electrode such that the current-application longitudinal segment is disposed entirely in a nucleus pulposus of the intervertebral disc.
14. The method according to claim 12 , wherein implanting the at least a portion of the electrode comprises implanting the at least a portion of the electrode such that the current-application longitudinal segment is disposed partially in a nucleus pulposus of the intervertebral disc and partially in an annulus fibrosus of the intervertebral disc.
15. The method according to claim 12 ,
wherein the wire further includes an intermediate longitudinal segment, which (a) is longitudinally between the current-application longitudinal segment and the lead longitudinal segment, (b) has an entire longitudinal length of between 1 and 6 mm, in the absence of any applied forces, and (c) in the absence of any applied forces, either (i) is coiled, and has a mean pitch greater than an outer coil diameter of the current-application longitudinal segment or (ii) is not coiled, and
wherein implanting the at least a portion of the electrode comprises implanting the at least a portion of the electrode such that the intermediate longitudinal segment is disposed at least in part in an annulus fibrosus of the intervertebral disc.
16. The method according to claim 15 , wherein the intermediate longitudinal segment is electrically insulated along at least a longitudinal portion of the intermediate longitudinal segment.
17. The method according to claim 15 , wherein the intermediate longitudinal segment is not coiled, in the absence of any applied forces.
18. The method according to claim 15 , wherein, in the absence of any applied forces, the intermediate longitudinal segment is coiled, and has the mean pitch greater than the outer coil diameter of the current-application longitudinal segment.
19. The method according to claim 1 ,
wherein the wire further includes an intermediate longitudinal segment, which (a) is longitudinally between the current-application longitudinal segment and the lead longitudinal segment, and (b) has an entire longitudinal length of between 1 and 6 mm, in the absence of any applied forces, and
wherein the electrode further includes a water-permeable element that surrounds at least a longitudinal portion of the intermediate longitudinal segment.
20. The method according to claim 1 , further comprising electrically coupling, to the electrode, control circuitry that is configured to drive the electrode to apply a current.