Porous composite material

1. A method for producing a modified porous composite material, the method comprising:

(a) providing a porous composite material comprising a biodegradable and bioabsorbable organic polymer having bioactive particles dispersed therein, wherein an overall porosity of the composite material is 60-80%, an average pore size is 200-500 μm, and a content of the bioactive particles in the composite material is 50-80% by weight, wherein the biodegradable and bioabsorbable organic polymer is a poly-L-lactide-co-ε-caprolactone copolymer comprising 70 molar-% L-lactide and 30 molar-% caprolactone, wherein the bioactive particles are selected from the group consisting of bioceramic particles, bioactive glass particles, and combinations thereof, wherein at least 50% of pores of the porous composite material are connected to each other by channels, wherein the width of the channels is at least 5 μm:

(b) immersing the porous composite material into a fluid and/or heating at 25-40° C., wherein the fluid is selected from the group consisting of water, saline, and a body fluid,

(c) following the immersing and/or heating, squeezing the porous composite material by subjecting the porous composite material to an external force, and

(d) releasing the external force.

2. The method according to claim 1 , wherein the fluid is a body fluid, and wherein the body fluid is selected from blood and bone marrow aspirate.

3. The method according to claim 1 , where the fluid is a body fluid, and wherein the body fluid comprises cells.

4. The method according to claim 1 , wherein the bioceramic particles are selected from the group consisting of unsintered and uncalcinated hydroxyapatite, α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP), tetracalcium phosphate, dicalcium phosphate dehydrate, dicalcium phosphate anhydride, and octacalcium phosphate.

5. The method according to claim 1 , wherein the external force is 0.5-100 N.

6. The method according to claim 1 , wherein the bioactive particles comprise β-tricalcium phosphate (β-TCP).

7. The method according to claim 1 , wherein the bioactive particles are granular.

8. The method according to claim 1 , wherein, in the step (b), the porous composite material is immersed into a fluid.

9. The method according to claim 1 , wherein, the step (b), the porous composite material is immersed into a fluid and heated at 25-40° C.

10. A method for producing a modified porous composite material, the method comprising:

(A) melt mixing a biodegradable and bioabsorbable organic polymer and bioactive particles dispersed therein to produce a porous composite material, wherein an overall porosity of the composite material is 60-80%, an average pore size is 200-500 μm wherein a content of the bioactive particles in the composite material is 50-80% by weight, wherein the biodegradable and bioabsorbable organic polymer is a poly-L lactide-co-ε-caprolactone copolymer comprising 70 molar-% L-lactide and 30 molar-% caprolactone, and wherein the bioactive particles are selected from bioceramic particles, bioactive glass particles, and mixtures thereof, and wherein at least 50% of pores of the porous composite material are connected to each other by channels, wherein the width of the channels is at least 5 μm,

(B) forming one or more holes to the composite material,

(C) optionally filling one or more of the one or more holes with bioactive particles selected from bioceramic particles, bioactive glass particles and mixtures thereof, wherein the method further comprises, for producing the porous composite material,

(D) saturating the composite material with CO 2 under conditions wherein CO 2 pressure is at least 74 bar and temperature is between 31° C. and melting temperature of crystalline phase of the organic polymer, and

(E) decreasing the CO 2 pressure to 1 bar, and keeping temperature between 31° C. and melting temperature of crystalline phase of the organic polymer, and wherein the method further comprises:

(I) immersing the porous composite material into a fluid and/or heating at 25-40° C., wherein the fluid is selected from the group consisting of water, saline, and a body fluid,

(II) following the immersing and/or heating, squeezing the porous composite material by subjecting to an external force, and

(III) releasing the external force.

11. The method according to claim 10 , wherein the saturating is done for 10 to 120 min.

12. The method according to claim 10 , wherein the decreasing the CO 2 pressure to 1 bar is done at a rate from 0.8 bar/min to 10 bar/min.

13. The method according to claim 10 , wherein the fluid comprises a body fluid, and wherein the body fluid is selected from the group consisting of blood and bone marrow aspirate.

14. The method according to claim 10 , wherein the fluid comprises a body fluid, and wherein the body fluid comprises cells.

15. The method according to claim 10 , wherein the bioceramic particles are selected from the group consisting of unsintered and uncalcinated hydroxyapatite, α-TCP, β-TCP, tetracalcium phosphate, dicalcium phosphate dehydrate, dicalcium phosphate anhydride, and octacalcium phosphate.

16. A method for producing a modified porous composite material, the method comprising:

(a) providing a porous composite material comprising a biodegradable and bioabsorbable organic polymer having bioactive particles dispersed therein, wherein an overall porosity of the composite material is 60-80%, an average pore size is 200-500 μm, and a content of the bioactive particles in the composite material is 50-80% by weight, wherein the biodegradable and bioabsorbable organic polymer is a poly-L-lactide-co-ε-caprolactone copolymer comprising 70 molar-% L-lactide and 30 molar-% caprolactone, wherein the bioactive particles are selected from the group consisting of bioceramic particles, bioactive glass particles, and combinations thereof, wherein at least 50% of pores of the porous composite material are connected to each other by channels, wherein the width of the channels is at least 5 μm:

(b) immersing the porous composite material into a fluid and heating at 25-40° C.,

(c) following the immersing and heating, squeezing the porous composite material by subjecting the porous composite material to an external force, and

(d) releasing the external force.