Pyrethroid spray formulations and methods of using the same
Sprayable compositions comprising a pyrethroid, a viscosity building agent, an emulsifier or surfactant, and an emollient are provided. The compositions have a viscosity that allows for delivery of the spray from a pressurized container such that the pyrethroid is administered in a consistent amount that uniformly covers the body of a subject. This obviates the need to rub the composition into the skin. In preferred embodiments, the pyrethroid is permethrin; the viscosity building agent is selected from the group consisting of carbomers, xanthan gum, or a combination thereof; the emulsifier or surfactant is selected from the group consisting of glyceryl mononstearate, PEG40 hydrogenated castor oil, cholesterol, steareth-10, steareth-20, and combinations thereof; and the emollient is selected from the group consisting of C12-C15 alkyl benzoates, diisopropyl adipate, silicon oil, mineral oil, or any combination thereof.
1. A sprayable composition comprising:
between about 2.5% and about 7.5% by weight permethrin;
between about 0.01% and about 0.2% by weight of a viscosity building agent comprising a carbomer;
between about 1% and about 10% by weight of an emulsifier/surfactant comprising cholesterol; and
between about 1% and about 60% by weight of an emollient comprising mineral oil, diisopropyl adipate, and silicon oil.
2. The sprayable composition of claim 1 , wherein the composition comprises between about 0.5% and about 10% by weight of the diisopropyl adipate.
3. The sprayable composition of claim 1 , wherein the composition comprises between about 0.5% and about 10% by weight of the mineral oil.
4. The sprayable composition of claim 1 , wherein the composition comprises about 5% by weight permethrin.
5. The sprayable composition of claim 1 , wherein the composition comprises between about 0.1% and about 5% of the cholesterol.
6. The sprayable composition of claim 1 , further comprising a preservative, a humectant, an antioxidant, and/or a pH-adjusting agent.
7. The sprayable composition of claim 6 , wherein the preservative comprises methyl paraben, propyl paraben, or a combination thereof.
8. The sprayable composition of claim 7 , wherein the composition comprises between about 0.02% and about 0.3% by weight of the methyl paraben.
9. The sprayable composition of claim 7 , wherein the composition comprises between about 0.01% and about 0.3% by weight of the propyl paraben.
10. The sprayable composition of claim 6 , wherein the humectant comprises propylene glycol, glycerin, or a combination thereof.
11. The sprayable composition of claim 10 , wherein the composition comprises between about 0.5% and about 10% by weight of the propylene glycol.
12. The sprayable composition of claim 6 , wherein the pH adjustment agent is sodium hydroxide.
13. The sprayable composition of claim 12 , wherein the composition comprises between about 0.01% and about 3.0% by weight of the sodium hydroxide.
14. The sprayable composition of claim 1 , wherein the composition does not comprise a propellant.
15. A method for treating an infestation of an arthropod in a subject in need of such treatment, the method comprising:
topically administering to the subject a therapeutically effective amount of the sprayable composition of claim 1 .
16. A Bag-on-Valve (BoV) aerosol system comprising:
an aerosol valve; and
an attached bag containing the sprayable composition of claim 1 .
17. A sprayable composition comprising:
about 5% by weight permethrin;
between about 0.1% and about 0.2% by weight of a carbomer;
between about 0.1% and about 5% by weight of a cholesterol;
between about 5% and about 10% by weight of a mineral oil;
between about 2.5% and about 7.5% by weight diisopropyl adipate; and
between about 2.5% and about 7.5% by weight of a silicon oil.
18. The sprayable composition of claim 17 , further comprising:
between about 0.02% and about 0.3% by weight methyl paraben;
between about 0.01% and about 0.3% by weight propyl paraben;
between about 1% and about 5% by weight propylene glycol; and
between about 0.01% and about 0.5% by weight butylated hydroxytoluene.