Pyrimidine prodrugs for the treatment of viral infections and further diseases
This invention relates to pyrimidine prodrug derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.
1. A compound of formula (I)
or a pharmaceutically acceptable salt, solvate or polymorph thereof, wherein
R 1A is hydrogen or a substituted or unsubstituted C 1-3 alkyl,
R 1B is selected from, a substituted or unsubstituted C 1-3 alkyl, heterocycle, or a substituted or unsubstituted phosphoramidate, and
R 2 is a C 1-8 alkyl optionally substituted by a hydroxyl group.
2. A compound according to claim 1 wherein R 1A or R 1B are a substituted or unsubstituted phosphoramidate and wherein R 2 is a C 1-6 alkyl substituted by a hydroxyl group.
3. A compound according to claim 1 wherein R 1A or R 1B are methyl and wherein R 2 is a C 6 -alkyl substituted by a hydroxyl group.
4. A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof according to claim 1 together with one or more pharmaceutically acceptable excipients, diluents or carriers.
5. A compound according to claim 1 wherein R 1A and R 1B are a substituted or unsubstituted phosphoramidate and wherein R 2 is a C 1-6 alkyl substituted by a hydroxyl group.
6. A compound according to claim 1 wherein R 1A and R 1B are methyl and wherein R 2 is a C 6 -alkyl substituted by a hydroxyl group.
7. A pharmaceutical composition comprising a compound according to claim 2 together with one or more pharmaceutically acceptable excipients, diluents or carriers.
8. A pharmaceutical composition comprising a compound according to claim 5 together with one or more pharmaceutically acceptable excipients, diluents or carriers.
9. A method for treating a virus infection, comprising administering to a subject in need thereof the pharmaceutical composition according to claim 4 in an effective amount to treat the virus infection.
10. A method for treating according to claim 9 , wherein the virus infection is a hepatitis B infection.
11. A method for treating an immune disorder, comprising administering to a subject in need thereof the pharmaceutical composition according to claim 4 in an effective amount to treat the immune disorder.
12. A method for treating cancer, comprising administering to a subject in need thereof the pharmaceutical composition according to claim 4 in an effective amount to treat the cancer.
13. The compound of claim 1 selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.