Oxysterols and methods of use thereof
Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R 2 , R 3 , R 4 , R 5 , and and R 6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
1. A compound of Formula (I-66):
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is substituted or unsubstituted C 1 -C 6 alkyl;
R 2 is substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaralkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
R 3 is hydrogen, substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
each of R 4 and R 5 is independently hydrogen, halo, or —OR C , wherein R C is hydrogen or unsubstituted or substituted C 1 -C 3 alkyl, or
R 4 and R 5 , together with the carbon atom to which they are attached, form an oxo group;
R 6 is absent or hydrogen; and
represents a single or double bond, wherein when one of is a double bond, the other is a single bond; wherein when both of are single bonds, R 6 is hydrogen; and wherein when one of is a double bond, R 6 is absent.
2. The compound of claim 1 , or the pharmaceutically acceptable salt thereof, wherein R 2 is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted aralkyl.
3. A compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of:
4. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
5. The compound of claim 2 , or the pharmaceutically acceptable salt thereof, wherein R 2 is substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, or substituted or unsubstituted pyridyl.
6. The compound of claim 5 , or the pharmaceutically acceptable salt thereof, wherein R 2 is unsubstituted phenyl, unsubstituted benzyl, or unsubstituted pyridyl.
7. The compound of claim 3 , wherein the compound is selected from the group consisting of:
8. The pharmaceutically acceptable salt of claim 3 , wherein the compound is selected from the group consisting of: