Whole-body hyperthermia system

1. A whole-body hyperthermia system for raising the body temperature of the entire body of an individual to a predetermined target temperature Tb and for stabilizing said body temperature at said target temperature Tb, said system comprising:

a cabinet, in which the individual is located, said cabinet being provided with isolation and heating for heating the air of the cabinet, for maintaining an individual at an elevated temperature,

at least one thermal means, configured to raise said body temperature at a rate of at least 1° C./hour, and subsequently set to obtain and maintain the target temperature Tb of said individual,

wherein said at least one thermal means comprises a first thermal means for raising said body temperature at a rate of at least 1° C./hour,

wherein raising said body temperature by said first thermal means is not performed by external heating of the blood system and

wherein said first thermal means do not comprise an internally heated fluid circuit,

one or more devices to prevent or counter heat loss from the individual, said one or more devices being devices for heating liquids being introduced in the body, said liquids comprising one or more of nutrients, liquids for hydration, liquids with medicaments, and liquids with anaesthetics,

one or more sensors monitoring the temperature or heat flux of the individual, connected to controllers steering said devices to prevent or counter heat loss and steering the at least one thermal means,

wherein said first thermal means has at least a first portion and at least a second portion, wherein the at least first portion of the first thermal means is arranged to raise the body temperature of at least a first series of body parts of the individual to the target temperature T b , and

wherein the at least second portion of the first thermal means is arranged to prevent at least a second series of body parts to exceed a target temperature T s ,

wherein the temperature T s is lower than the temperature T b ,

wherein said second portion further includes means for cooling individual organs,

wherein said means for cooling individual organs are applied to the brain and at least one of the liver, the kidneys and the colon, and in that, said system further comprises means for bringing the individual under anaesthesia.

2. The system according to claim 1 , wherein the one or more sensors monitoring the temperature of the individual comprise one or more of sensors measuring the temperature internally, sensors measuring the temperature externally and contacting the skin, and sensors measuring the temperature externally and not contacting the skin.

3. The system according to claim 1 , wherein said at least one thermal means further comprises at least a second thermal means for further adjusting the body temperature to said target temperature Tb,

wherein said second thermal means comprise a fluid circuit, which is at least partially within the individual,

wherein a fluid, heated by a heat exchanger to a set temperature Tf, is circulated through said fluid circuit, wherein Tf is Tb+/−0.5° C.

4. The whole-body hyperthermia system according to claim 3 , wherein said first and said second thermal means are different from each other.

5. The whole-body hyperthermia system according to claim 3 , wherein said fluid circuit of the second thermal means is an internally heated catheter.

6. The whole-body hyperthermia system according to claim 1 , wherein said system is provided with means for monitoring the body temperature and vital signs of the individual, such as respiratory activity, cardiac activity and blood parameters.

7. The whole-body hyperthermia system according to claim 1 , wherein said system is provided with means to administer additional compounds to the individual, such as transfused blood, chemotherapeutic drugs and/or nutritional compounds, such as salt solutions, and wherein said additional compounds are administered at a temperature Tb, and/or

wherein said system is provided with one or more isolation elements for an individual, such as isolation foil or suit for torso or limbs, or a helmet or cap like device for application on the head.

8. The system according to claim 1 , wherein said means for cooling individual organs are provided on the skin of the individual nearby the location of the organ, configured to provide cooling through the skin, or are applied on the surface of the organ itself by use of minimally invasive or keyhole surgery.

9. The system according to claim 1 , wherein said means for cooling individual organs are a disposable means.

10. A disposable kit for use in the system according to claim 1 , wherein said disposable kit comprises tubing for a fluid circuit for blood supply to an individual and comprises sensors to monitor the temperature or heat loss from the patient.