IP Library › Granted Patent US 11,493,491
Granted Patent B2
US 11,493,491 · App. 16/352,579 · Granted Nov 8, 2022

Chemical sensor and method for detecting target substance

Inventors: Atsunobu Isobayashi (Yokohama, JP); Yoshiaki Sugizaki (Fujisawa, JP); Sadato Hongo (Yokohama, JP)
Assignee: KABUSHIKI KAISHA TOSHIBA
G01N33/0031G01N1/4005G01N27/40G01N33/0036G01N33/0062G01N2333/72
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Quick Facts
Patent No.
US 11,493,491
App. No.
16/352,579
Granted
Nov 8, 2022
Kind
B2
Abstract

A chemical sensor for detecting a target substance in a gas sample, including a membrane; and an olfactory receptor fragment which is fixed to the membrane. The chemical sensor optionally includes a source electrode connected to one end of the membrane; and a drain electrode connected to the other end of the membrane, in which the membrane is a graphene.

Claims (38)

1. A chemical sensor, comprising:

a membrane;

an olfactory receptor fragment which is fixed to the membrane;

a source electrode connected to one end of the membrane;

a drain electrode connected to the other end of the membrane;

a liquid phase which is provided on the membrane to coat the olfactory receptor fragment; and

a target substance transporting carrier contained in the liquid phase,

wherein

the membrane is a graphene, and

the target substance transporting carrier has a pocket-like shape having a hydrophilic part on an outer side and a hydrophobic part on an inner side.

2. The chemical sensor of claim 1 , wherein a thickness of the liquid phase is greater than 0 μm and equal to or less than 50 μm.

3. The chemical sensor of claim 1 , wherein the target substance transporting carrier is an odorant binding protein or an inclusion compound.

4. The chemical sensor of claim 1 , further comprising:

a blocking agent provided on a surface of the membrane to which the olfactory receptor fragment is fixed.

5. The chemical sensor of claim 4 , wherein the blocking agent is an acidic substance.

6. A chemical sensor, comprising:

an olfactory receptor fragment which is capable of binding to a target substance; and

a detector which detects a physical property change due to the binding of the target substance and the olfactory receptor fragment.

7. A chemical sensor, comprising:

a membrane; and

a target substance transporting carrier fixed to the membrane,

wherein the target substance transporting carrier has a pocket-like shape having a hydrophilic part on an outer side and a hydrophobic par on an inner side.

8. The chemical sensor of claim 7 , further comprising:

a source electrode connected to one end of the membrane; and

a drain electrode connected to the other end of the membrane,

wherein the membrane is a graphene.

9. The chemical sensor of claim 7 , further comprising:

a liquid phase which is provided on the membrane to coat the olfactory receptor fragment.

10. The chemical sensor of claim 9 , wherein a thickness of the liquid phase is greater than 0 μm and equal to or less than 50 μm.

11. The chemical sensor of claim 7 , further comprising:

a blocking agent provided on a surface of the membrane to which the target substance transporting carrier is fixed.

12. The chemical sensor of claim 11 , wherein the blocking agent is a basic substance.

13. The chemical sensor of claim 7 , wherein the target substance transporting carrier is an odorant binding protein or an inclusion compound.

14. A chemical sensor, comprising:

a target substance transporting carrier which has a pocket-like shape having a hydrophilic part on an outer side and a hydrophobic part on an inner side; and

a detector which detects a physical property change due to the binding of a target substance and the target substance transporting carrier.

15. The chemical sensor of claim 1 , wherein a target substance to be detected by the chemical sensor is an odorant.

16. The chemical sensor of claim 1 , wherein the membrane is a sensitive membrane to a target substance to be detected by the chemical sensor.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 22, 2019
From: ISOBAYASHI, ATSUNOBU; SUGIZAKI, YOSHIAKI; HONGO, SADATO
To: KABUSHIKI KAISHA TOSHIBA
Reel/Frame 049252/0794 →
Priority Claims (1)
JP JP2018-170654 · Sep 12, 2018 · national
Continuity (1)
Related Publication 20200080977A1 · Mar 12, 2020