Devices and methods for endoluminal delivery of either fluid or energy for denervation
Described herein are methods and devices for selectively applying either fluids (e.g., anesthetics, nerve-blockers, etc.) or energy, such as radiofrequency or ultrasound energy, to a target tissue from within a blood vessel while minimizing the amount of fluid or energy applied to non-target tissue. The catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter. In addition, catheters can include energy applying features for delivering energy to the target tissue.
1. A catheter device, comprising:
an elongate body having a distal region and a proximal region;
a first inflatable holdfast positioned along the elongate body adjacent the distal region of the elongate body;
a second inflatable holdfast positioned along the elongate body adjacent the first inflatable holdfast, the first inflatable holdfast and the second inflatable holdfast being configured to inflate and anchor the catheter device within an artery; and
an energy providing feature secured to the elongate body at a first location between the first and second inflatable holdfasts, the energy providing feature configured to deliver energy from the first location,
wherein the second inflatable holdfast is positioned a distance from the first inflatable holdfast, the distance allowing the energy providing feature to be securely positioned adjacent a vascular body when the first inflatable holdfast and the second inflatable holdfast are inflated within an artery thereby allowing the energy providing feature to deliver energy from the first location to a vascular body.
2. The catheter device of claim 1 , wherein the energy delivered to the target area is radiofrequency energy.
3. The catheter device of claim 1 , wherein the energy delivered to the target area is ultrasound energy.
4. The catheter device of claim 1 , wherein the energy providing feature includes an electrode.
5. The catheter device of claim 1 , wherein the energy providing feature includes a transducer and an acoustic element.
6. The catheter device of claim 1 , wherein the elongate body has a length suitable for treatment of a vascular body via a transcervical approach.
7. The catheter device of claim 6 , wherein the length of the elongate body is within a range of approximately 40 centimeters to 80 centimeters.
8. The catheter device of claim 1 , further comprising:
a passageway extending along a part of the elongate body, the passageway including a distal region positioned at a second location between the first inflatable holdfast and the second inflatable holdfast; and
an injector slidably engaged with the passageway and configured to extend from the elongate body at the second location and into tissue.
9. The catheter device of claim 8 , wherein the first inflatable holdfast and the second inflatable holdfast are asymmetrically positioned along the elongate body thereby positioning at least one of the energy providing feature and the distal region of the passageway against an inner wall of an artery when the first inflatable holdfast and the second inflatable holdfast are inflated.