Hollow body, in particular for packaging a pharmaceutical composition, having a layer of glass and a surface region with a contact angle for wetting with water
A hollow body includes a wall which at least partially surrounds an interior volume of the hollow body. The wall comprises a layer of glass and has a wall surface. The wall surface comprises a surface region which is characterized by a contact angle for wetting with water of at least 80°. A process for making an item; a hollow body obtainable by this process; a closed container; a process for packaging a pharmaceutical composition; a closed hollow body obtainable by this process; a use of one of the hollow bodies; and a use of a perfluorinated silane or a perfluorosulfonic acid or both is also provided.
1. A hollow body, comprising:
a wall which at least partially surrounds an interior volume of the hollow body, the wall comprising a layer of glass and a wall surface, the wall surface comprising a surface region which is characterized by a contact angle for wetting with water of at least 80° and a contact angle for wetting with n-hexadecane of at least 69°, wherein the contact angle for wetting with water and the contact angle for wetting with n-hexadecane are both determined in accordance with the standard DIN 55660 part 1 and part 2 on a curved surface at an ambient temperature of 22° C. to 25° C. and a relative atmospheric humidity of 20% to 35%; and
a functionalizing composition superimposing the layer of glass and defining the surface region of the wall surface, wherein the functionalizing composition is formed from a first composition precursor that is applied to the wall surface and comprises inorganic particles dispersed in water and a polysorbate, and a second composition precursor that differs from and is applied to the first composition precursor applied to the wall surface, the second composition precursor comprising a perfluorosulfonic acid; wherein the second composition precursor forms a plurality of regions which each have a diameter in a range from 1 to 100 μm and include the perfluorosulfonic acid, and the plurality of regions discontinuously superimpose the organic inorganic particles of the first composition precursor applied to the wall surface.
2. The hollow body according to claim 1 , wherein the wall surface comprises an interior surface which faces the interior volume and an exterior surface which faces away from the interior volume, wherein at least one of the interior surface or the exterior surface comprises the surface region defined by the functionalizing composition.
3. The hollow body according to claim 1 , wherein the wall surface comprises an interior surface which faces the interior volume and an exterior surface which faces away from the interior volume and comprises the surface region defined by the functionalizing composition, wherein the interior surface is characterized across its full area by a contact angle for wetting with water of less than 80°.
4. The hollow body of claim 1 , wherein the surface region defined by the functionalizing composition has an increase in a haze of the hollow body with respect to an untreated hollow body of 0.3 or less.
5. The hollow body of claim 1 , wherein the hollow body has a transmission coefficient for a transmission of a light of a wavelength in a range from 430 nm to 490 nm through the hollow body via the surface region of more than 0.7.
6. A closed container, comprising:
a wall at least partially surrounding an interior volume which comprises a pharmaceutical composition, the wall comprising a layer of glass and having a wall surface comprising a surface region which faces away from the interior volume and is characterized by a contact angle for wetting with water of at least 80 and a contact angle for wetting with n-hexadecane of at least 69°, wherein the contact angle for wetting with water and the contact angle for wetting with n-hexadecane are both determined in accordance with the standard DIN 55660 part 1 and part 2 on a curved surface at an ambient temperature of 22° C. to 25° C. and a relative atmospheric humidity of 20% to 35%; and
a functionalizing composition superimposing the layer of glass and defining the surface region of the wall surface, wherein the functionalizing composition is formed from a first composition precursor that is applied to the wall surface and comprises inorganic particles dispersed in water and a polysorbate, and a second composition precursor that differs from and is applied to the first composition precursor applied to the wall surface, the second composition precursor comprising a perfluorosulfonic acid; wherein the second composition precursor forms a plurality of regions which each have a diameter in a range from 1 to 100 μm and include the perfluorosulfonic acid, and the plurality of regions discontinuously superimpose the inorganic particles of the first composition precursor applied to the wall surface.
7. The closed container of claim 6 , wherein the wall comprises inorganic particles at least partially superimposed by the functionalizing composition.
8. A hollow body, comprising:
a wall which at least partially surrounds an interior volume of the hollow body, the wall comprising a layer of glass and a wall surface, the wall surface comprising a surface region which is characterized by a contact angle for wetting with water of at least 80 and a contact angle for wetting with n-hexadecane of at least 69°, wherein the contact angle for wetting with water and the contact angle for wetting with n-hexadecane are both determined in accordance with the standard DIN 55660 part 1 and part 2 on a curved surface at an ambient temperature of 22° C. to 25° C. and a relative atmospheric humidity of 20% to 35%; and
a functionalizing composition superimposing the layer of glass and defining the surface region of the wall surface, wherein the functionalizing composition is formed from a first composition precursor that is applied to the wall surface and comprises inorganic particles dispersed in water and a polysorbate, and a second composition precursor that differs from and is applied to the first composition precursor applied to the wall surface, the second composition precursor comprising a perfluorinated silane; wherein the second composition precursor forms a plurality of regions which each have a diameter in a range from 1 to 100 μm and include the perfluorinated silane, and the plurality of regions discontinuously superimpose the inorganic particles of the first composition precursor applied to the wall surface.