Graphene field effect transistors for detection of ions
A graphene-based ion sensitive field effect transistor (GISFET) with high sensitivity and selectivity for ions is provided. For example, the GISFET of the present invention can exhibit high sensitivity and selectivity for K + ions has been demonstrated utilizing a valinomycin-based ion selective membrane. The sensitivity of the GISFET can be at least about 50 millivolts/decade and can be stable for a time period of about two months, indicating the GISFET's reliability and effectiveness for physiological monitoring.
1. A graphene ion selective field effect transistor comprising:
a substrate;
a graphene film disposed on the substrate; and
an ion selective membrane disposed on the graphene film, wherein the ion selective membrane comprises an ionophore, a lipophilic salt, and a polymer; the polymer being a block copolymer having a continuous amorphous phase and a discontinuous crystalline phase and having a molecular weight ranging from about 100 , 000 Daltons to about 200,000 Daltons.
2. The graphene ion selective field effect transistor of claim 1 , wherein the polymer has a glass transition temperature ranging from about −20° C. to about −60° C.
3. The graphene ion selective field effect transistor of claim 1 , wherein the continuous amorphous phase comprises n-butyl acrylate and the discontinuous crystalline phase comprises methyl methacrylate.
4. The graphene ion selective field effect transistor of claim 3 , wherein the n-butyl acrylate is present in the polymer in an amount ranging from about 82 wt.% to about 97.5 wt.% and the methyl methacrylate is present in the polymer in an amount ranging from about 2.5 wt.% to about 18 wt.%.
5. The graphene ion selective field effect transistor of claim 1 , wherein the ion selective membrane is selective for potassium ions, sodium ions, calcium ions, or cadmium ions.
6. The graphene ion selective field effect transistor of claim 5 , wherein the ion selective membrane is selective for potassium ions.
7. The graphene ion selective field effect transistor of claim 6 , wherein the ionophore comprises valinomycin.
8. The graphene ion selective field effect transistor of claim 1 , wherein the lipophilic salt comprises potassium tetrakis (4-chlorophenyl) borate (K-TCPB), sodium tetrakis (4-fluorophenyl) borate, sodium tetraphenyl borate, ammonium tetrakis (chlorophenyl) borate, or a combination thereof.
9. The graphene ion selective field effect transistor of claim 1 , wherein the ionophore is present is present in an amount ranging from about 0.5 wt.% to about 4 wt.% of the total weight of the ion selective membrane.
10. The graphene ion selective field effect transistor of claim 1 , wherein the lipophilic salt is present in an amount ranging from about 0.1 wt.% to about 0.5 wt.% of the total weight of the ion selective membrane.
11. The graphene ion selective field effect transistor of claim 1 , wherein the polymer is present in an amount ranging from about 95 wt.% to about 99 wt.% of the total weight of the ion selective membrane.
12. The graphene ion selective field effect transistor of claim 1 , wherein the ion selective membrane has a thickness ranging from about 0.25 micrometers to about 20 micrometers.
13. The graphene ion selective field effect transistor of claim 1 , further comprising a source contact and a drain contact, wherein the substrate, the graphene film, the source contact, and the drain contact are encapsulated, leaving a portion of the ion sensitive membrane exposed for receiving a test solution.
14. The graphene ion selective field effect transistor of claim 1 , wherein the graphene ion selective field effect transistor is stable for at least two months.
15. The graphene ion selective field effect transistor of claim 1 , wherein the graphene ion selective field effect transistor detects ions at concentrations ranging from about 0.5 micromolar to about 20 millimolar.
16. The graphene ion selective field effect transistor of claim 1 , wherein the graphene ion selective field effect transistor exhibits an ion sensitivity of at least about 50 millivolts/decade.
17. The graphene ion selective field effect transistor of claim 1 , wherein the substrate comprises silicon polyethylene terephthalate (PET), polyethylene naphthalate (PEN), polyether ether ketone (PEEK), polyimide (PI), or a combination thereof.
18. An ion sensing device comprising the graphene ion selective field effect transistor of claim 1 , wherein the graphene ion selective field effect transistor is mounted onto a printed circuit board.
19. An array comprising at least two of the graphene ion selective field effect transistor of claim 1 .
20. A method of forming the graphene ion selective field effect transistor of claim 1 , the method comprising:
positioning the graphene film on the substrate;
depositing a source contact and a drain contact on the graphene film;
coating a solution containing the ionophore, the lipophilic salt, and the polymer onto the graphene film to form the ion selective membrane, wherein the polymer is the block copolymer having the continuous amorphous phase and the discontinuous crystalline phase and having the molecular weight between 100,000 Daltons and 200,000 Daltons; and encapsulating the graphene ion selective field effect transistor such that a portion of the ion selective membrane is exposed.