Kv7 channel activators compositions and methods of use
Provided herein are optionally substituted benzoimidazol-1,2-yl amides, pharmaceutical compositions comprising a therapeutically effective amount of such compounds and a pharmaceutically acceptable excipient, and methods of treating Kv7 associated diseases, such as, epilepsy, amyotrophic lateral sclerosis, various types of pain, hyperexcitability, a dyskinesia, dystonia, mania and tinnitus with such compounds and pharmaceutical compositions.
1. A compound selected from the group consisting of:
or a
pharmaceutically acceptable salt thereof.
2. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
3. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
4. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising a compound of claim 1 .
6. A pharmaceutical composition comprising a compound of claim 2 .
7. A pharmaceutical composition comprising a compound of claim 3 .
8. A pharmaceutical composition comprising a compound of claim 4 .
9. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
10. A pharmaceutical composition comprising a compound of claim 9 .
11. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
12. A pharmaceutical composition comprising a compound of claim 11 .
13. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
14. A pharmaceutical composition comprising a compound of claim 13 .
15. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
16. A pharmaceutical composition comprising a compound of claim 15 .
17. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
18. A pharmaceutical composition comprising a compound of claim 17 .
19. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
20. A pharmaceutical composition comprising a compound of claim 19 .
21. The compound of claim 2 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
22. A pharmaceutical composition comprising a compound of claim 21 .
23. The compound of claim 2 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
24. A pharmaceutical composition comprising a compound of claim 23 .
25. The compound of claim 2 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
26. A pharmaceutical composition comprising a compound of claim 25 .
27. The compound of claim 3 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
28. A pharmaceutical composition comprising a compound of claim 27 .