Granted Patent B2

US 12,351,559 · App. 18/490,942 · Granted Jul 8, 2025

Inventors: Lynn Resnick (Pittsburgh, PA); George T. Topalov (Pittsburgh, PA); Justin K. Belardi (Pittsburgh, PA); James S. Hale (Pittsburgh, PA); Scott S. Harried (Pittsburgh, PA); Charles A. Flentge (Mars, PA); David A. Mareska (McMurray, PA)

Assignee: Biohaven Therapeutics Ltd.

C07D235/30C07D401/04C07D401/12C07D403/04C07D405/12C07D413/04

Abstract

Claims (30)

1. A compound represented by a formula:

wherein:

D is isopropyl;

R 1 is CN; and

R 2 is H or F;

R 3 is H or F; and

R 4 is H;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein

3. The compound of claim 1 , wherein

4. The compound of claim 1 , wherein

5. The compound of claim 1 , wherein R 2 is H.

6. The compound of claim 1 , wherein R 2 is F.

7. The compound of claim 1 , wherein R 3 is H.

8. The compound of claim 1 , wherein R 3 is F.

9. A compound represented by a formula:

wherein:

D is optionally substituted cyclobutyl, isopropyl, or t-butyl;

R 1 is CN; and

R 2 is H or F;

R 3 is H or F; and

R 4 is H;

or a pharmaceutically acceptable salt thereof.

10. The compound of claim 9 , wherein D is optionally substituted cyclobutyl.

11. The compound of claim 9 , wherein D is optionally substituted isopropyl.

12. The compound of claim 9 , wherein D is optionally substituted t-butyl.

13. The compound of claim 9 , wherein R 2 is H.

14. The compound of claim 9 , wherein R 2 is F.

15. The compound of claim 9 , wherein R 3 is H.

16. The compound of claim 9 , wherein R 3 is F.

Continuity (9)

References Cited (63)