Implantable ocular drug delivery devices and methods
An implantable ocular drug delivery system can include inserting an implantable device into an eye, where the device contains therapeutics intended to be released for local or systemic effects. In some implantable device embodiments, the device includes a microchannel intended to reduce intraocular pressure. In some implantable device embodiments, the device includes a microchannel intended to treat dry eye.
1. An implantable ocular drug delivery device, comprising:
a body comprising:
a top outer polymer layer;
a bottom outer polymer layer; and
an inner polymer layer disposed between the top and bottom outer polymer layers and defining a reservoir and an inlet to the reservoir,
wherein the body includes a distal end portion and a proximal end portion, wherein the proximal end portion includes a crossbar tab that is a laterally wider than the distal end portion of the device; and
a drug releasing entity comprising a therapeutic agent, the drug releasing entity disposed within the reservoir defined by the inner polymer layer,
wherein the device is configured to be implanted through scleral tissue of an eye such that at least a distal end portion of the device is within an anterior chamber of the eye and the crossbar tab abuts an outer surface of the eye.
2. The device of claim 1 , wherein the top and bottom outer polymer layers comprise thermoplastic polyurethane.
3. The device of claim 1 , wherein the first and second outer polymer layers comprise polyethylene terephthalate (“PET”), Poly(methyl methacrylate) (“PMMA”), Polyurethane (“PU”), Polycarbonate (“PC”), Polyvinyl chloride (“PVC”), Polyvinyl alcohol (“PVA”), Polystyrene (“PS”), Thermoplastic polyurethane (“TPU”), Polyethylene (“PE”), Polysulfone, Polyethersulfone (“PES”), Sulfonated Polyethersulfone (“SPES”), Polybutylene terephthalate (“PBT”), Polyhydroxyalkanoates (“PHAs”), Silicone, Parylene, Polypropylene (“PP”), Fluoropolymers, Polyhydroxylethylmethacrylate (“pHEMA”), Polyetherketoneketone (“PEKK”), Polyether ether ketone (“PEEK”), Polyaryletherketone (“PAEK”), Poly(lactic-co-glycolic acid) (“PLGA”), Polytetrafluoroethylene (“PTFE”), Polyvinylidene fluoride (“PVDF”), or Polyacrylic acid (“PAA”).
4. The device of claim 1 , wherein the therapeutic agent is formulated to treat an ocular disease or ocular condition.
5. The device of claim 1 , wherein the therapeutic agent is formulated to treat a disease or condition outside of the eye.
6. The device of claim 1 , wherein the drug releasing entity comprises a polymeric matrix that includes poly(lactic acid), poly(glycolic acid), poly(lactide-co-glycolide), poly(anhydrides), poly(dioxanone), poly(amides), poly(hydroxy butyrate), polyester, poly(caprolactone), poly(adepic acid), poly(sebacic acid), poly(terpthalic acid), poly(amino acids), poly(glutamic acid), poly(imino carbonate), poly(phosphates), poly(phosphonates), poly(phosphazenes), poly(cyanoacrylates), poly(urethanes), poly(ortho ester), poly(acetals), poly(dimethylsiloxane), poly(urethane), poly(amido amines), poly(amide-enamines), poly(acrylates), poly(acrylamides), poly(carbophil), poly(acrylic acid), poly(ethylene-vinyl acetate), poly(vinyl alcohol), poly(enol-ketone), poly(ethylene), poly(propylene), poly(vinyl chloride), poly(ortho esters), poly(ether-ester), collagen, albumin, gelatin, alginate, cyclodextrin, chitosan, dextran, agarose, hyaluronic acid, starch, or cellulose.
7. The device of claim 1 , wherein the inner polymer layer comprises an anti-biofouling polymer.
8. The device of claim 1 , wherein the inner polymer layer comprises polyethylene glycol (“PEG”) (e.g., an acrylate-PEG-acrylate such as triethylene glycol dimethacrylate), a polymerized zwitterion, N-(2-methacryloyloxy)ethyl-N, N-dimethylammonio propanesulfonate (“SPE”), N-(3-methacryloylimino)propyl-N, N-dimethylammonio propanesulfonate (“SPP”), 2-(methacryloyloxy)ethylphosphatidylcholine (“MPC”), 3-(2′-vinyl-pyridinio)propanesulfonate (“SPV”)), Poly(2-oxazoline)s (e.g. Poly(2-ethyl-2-oxazoline)), Poly(hydroxyfunctional acrylates) (e.g. Poly(2-hydroxyethyl methacrylate); Poly(glycerol)), poly(vinylpyrrolidone), peptides or peptoids (e.g. Poly(amino acid) or Poly(peptoid)).
9. The device of claim 1 , wherein the drug releasing entity contains the therapeutic agent and one or more of group consisting of: release enhancers, release-hindering agents, buffering agents, prodrugs, drug preservatives, diluents, and drug carriers.
10. The device of claim 1 , wherein the drug releasing entity is nonbiodegradable.
11. The device of claim 1 , wherein the device has a length between about 2 mm and 4 mm, a width between about 0.5 mm and 2 mm, and a height between around 0.1 mm and 0.5 mm.
12. The device of claim 1 , wherein a microchannel through the device is defined by the inner polymer layer and runs through the device along its length.
13. The device of claim 12 , wherein the microchannel is configured to reduce an intraocular pressure of the eye after implantation.
14. The device of claim 12 , wherein the microchannel is configured to treat dry eye.
15. The device of claim 1 , wherein the therapeutic agent is a first therapeutic agent, wherein the drug releasing entity further comprises a second therapeutic pharmacological agent, and wherein the first and second therapeutic agents are different types of therapeutic agents.
16. The device of claim 1 , wherein the drug releasing entity is exposed to aqueous humor via the inlet when the device is implanted within scleral tissue of an eye such that at least the distal end portion of the device is within an anterior chamber of the eye.
17. The device of claim 1 , wherein the reservoir is a first reservoir, and wherein the inner polymer also defines a second reservoir.
18. The device of claim 17 , wherein the first reservoir stems from a first inlet and the second reservoir stems from a second inlet, wherein the first and second inlets are within the anterior chamber of the eye while the device in implanted within the scleral tissue of the eye, and wherein other than the first and second inlets the remainder of the device is impermeable to aqueous fluids.
19. The device of claim 1 , wherein the crossbar tab has rounded corners.