Compositions for achieving therapeutically effective doses of anti-CD47 agents
Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.
1. A kit comprising:
a first container comprising a human sub-therapeutic unit dose consisting of 1 mg/kg of a first anti-CD47 antibody, wherein the sub-therapeutic dose is sufficient to increase production of reticulocytes; and
a second container comprising a human therapeutic unit dose consisting of from 10 mg/kg to 40 mg/kg of a second anti-CD47 antibody, wherein the therapeutic dose is sufficient to increase phagocytosis;
for use in a method of treating a patient with the anti-CD47 antibody.
2. The kit of claim 1 , wherein the first and the second anti-CD47 antibodies are the same antibody.