BIOACTIVE COMPOSITIONS AND METHODS FOR TREATING SKIN
Described are topical compositions optionally containing glycosaminoglycan stimulators, anti-aging agents, cosmetic peptides, and skin-conditioning agents, as well as a kit and methods for treating skin including administering described topical compositions.
1 . A topical composition comprising:
at least four agents selected from the group consisting of a first glycosaminoglycan (GAG) stimulator, a second GAG stimulator, a first anti-aging agent, a second anti-aging agent, a cosmetic peptide, and a skin-conditioning agent; and
optionally one or more additional agent,
wherein the composition does not include a retinoid, and
wherein the first GAG stimulator is not the same as the second GAG stimulator and the first anti-aging agent is not the same as the second anti-aging agent.
2 . The topical composition according to claim 1 , wherein the first GAG stimulator is one or more GAG stimulator selected from the group consisting of disodium acetyl glucosamine phosphate (DAGP), hydrolyzed sericin, sericin, hyaluronic acid and derivatives or salts thereof, SUBLISKIN®, HYALUFIX®, STIMULHYAL®, SYN-GLYCAN®, KALPARIANE®, DC Upregulex, DC Upregulex-Buddej a Complex, glucosamine, N-acetyl glucosamine, Arctium lappa fruit extract, Eriobotrya japonica extract, Genkwanin, N-Methyl-L-serine, (−)-alpha-bisabolol or synthetic alpha-bisabolol, oat glucan, Echinacea purpurea extract, soy protein hydrolysate, Sinorhizobium Meliloti Ferment Filtrate, Calcium ketogluconate, Alpinia galanga leaf extract and tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate.
3 . The topical composition according to claim 1 , wherein the second GAG stimulator is one or more GAG stimulator selected from the group consisting of disodium acetyl glucosamine phosphate (DAGP), hydrolyzed sericin, sericin, hyaluronic acid and derivatives or salts thereof, SUBLISKIN®, HYALUFIX®, STIMULHYAL®, SYN-GLYCAN®, KALPARIANE®, DC Upregulex, DC Upregulex-Buddej a Complex, glucosamine, N-acetyl glucosamine, Arctium lappa fruit extract, Eriobotrya japonica extract, Genkwanin, N-Methyl-L-serine, (−)-alpha-bisabolol or synthetic alpha-bisabolol, oat glucan, Echinacea purpurea extract, soy protein hydrolysate, Sinorhizobium Meliloti Ferment Filtrate, Calcium ketogluconate, Alpinia galanga leaf extract and tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate.
4 . The topical composition according to claim 1 , wherein the first and/or second anti-aging agents is one or more anti-aging agent selected from the group consisting of lactobacillus/panax ginseng root extract ferment filtrate, angelica polymorpha sinensis root extract, a flavonoid, Coenzyme Q10, inorganic sunscreens, vitamins and botanical extracts.
5 . The topical composition according to claim 1 , wherein the cosmetic peptide is one or more cosmetic peptide selected from the group consisting of argireline analogues, pentapeptide leuphasyl, acetyl hexapeptide, pentapeptide-3V and dipeptide diaminobutyroyl benzylamide diacetate.
6 . The topical composition according to claim 1 , wherein the skin-conditioning agent is selected from the group consisting of beta-glucan, aluminium hydroxide gel, calamine, cocoa butter, cod liver oil, cyclopentasiloxane, dirnethicone, dimethicone crosspolymer, dimethiconol, glycerine, kaolin, petrolatum, lanolin, mineral oil, shark liver oil, white petrolatum, talc, topical starch, zinc acetate, zinc carbonate, zinc oxide, live yeast cell derivatives, aldioxa, aluminum acetate, microporous cellulose, cholecalciferol, colloidal oatmeal, cysteine hydrochloride, dexpanthenol, protein hydrolysates, racemic methionine, sodium bicarbonate, vitamin A, buffered mixture of cation and anion exchange resins, corn starch, trolamine, bismuth subnitrate, boric acid, ferric chloride, polyvinylpyrrolidone-vinyl acetate, copolymers, sulfur, tannic acid, derivatives thereof and mixtures thereof.
7 . The topical composition according to claim 1 , wherein the one or more additional agent is selected from the group consisting of a carrier, a solvent, a humectant, a surfactant, a viscosity adjusting agent, an additional glycosaminoglycan (GAG) stimulator, a buffering agent, a thickener, an emollient, an emulsifier, an additional skin conditioning agent, an anti-inflammatory agent, an additional anti-aging agent, an anti-wrinkle agent, a DNA repair agent, an antioxidant, a pH adjuster, a fragrance, a preservative, an excipient, a filler and a diluent.
8 . A kit, comprising the topical composition according to claim 1 .
9 . A method for improving skin hydration comprising:
topically administering a therapeutically effective amount of the topical composition according to claim 1 to skin of a subject in need thereof.