Radiopaque monomers, polymers, microspheres, and methods related thereto
Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
1. A method of manufacturing a microsphere, comprising:
obtaining a solution comprising one or more monomers, wherein the one or more monomers comprises a first monomer having a structure according to Formula Ib:
polymerizing the one or more monomers to form a polymer; and
isolating a microsphere comprising the polymer, wherein the microsphere comprises a diameter of between about 10 microns and about 2000 microns, and wherein the microsphere is non-resorbable within a body of a patient such that a location of the microsphere can be detected more than about 48 hours after injection into the body of the patient.
2. The method of claim 1 , wherein the solution further comprises a second monomer selected from an acrylamide, an acrylic, an acrylate, or a methacrylate monomer.
3. The method of claim 1 , wherein the solution further comprises an acrylamide monomer.
4. The method of claim 3 , wherein the solution comprises at least one of N-[Tris(hydroxymethyl)methyl]acrylamide or N,N′-Methylenebis(acrylamide).
5. The method of claim 1 , further comprising:
cross-linking the polymer.
6. The method of claim 1 , wherein the microsphere further comprises a magnetic agent.
7. The method of claim 1 , wherein the microsphere further comprise a therapeutic agent.
8. The method of claim 1 , wherein the microsphere is non-resorbable within the body of the patient such that the location of the microsphere can be detected more than about a week after injection into the body of the patient.
9. A method of manufacturing a microsphere, comprising:
obtaining a monomer solution, wherein the monomer solution comprises:
a first monomer having a structure according to Formula Ib:
a second monomer selected from at least one of an acrylamide, an acrylic, an acrylate, or a methacrylate monomer;
polymerizing at least the first monomer and the second monomer to form a polymer, wherein a vinyl moiety of the monomer of Formula Ib is incorporated into a backbone of the polymer; and
isolating a microsphere comprising the polymer, wherein the microsphere comprises a diameter of between about 10 microns and about 2000 microns, and wherein the microsphere is non-resorbable within a body of a patient such that a location of the microsphere can be detected more than about 48 hours after injection into the body of the patient.
10. The method of claim 9 , wherein the second monomer comprises an acrylamide monomer.
11. The method of claim 10 , wherein the second monomer comprises at least one of N-[Tris(hydroxymethyl)methyl]acrylamide or N,N′-Methylenebis(acrylamide).
12. The method of claim 9 , wherein the microsphere further comprise a therapeutic agent.
13. The method of claim 9 , wherein the microsphere is non-resorbable within the body of the patient such that the location of the microsphere can be detected more than about a week after injection into the body of the patient.
14. A method of manufacturing a microsphere, comprising:
obtaining a monomer solution, wherein the monomer solution comprises:
a first monomer having a structure according to Formula Ib:
and
an acrylamide monomer;
polymerizing at least the first monomer and the acrylamide monomer to form a polymer, wherein a vinyl moiety of the monomer of Formula Ib is incorporated into a backbone of the polymer; and
isolating a microsphere comprising the polymer, wherein the microsphere comprises a diameter of between about 10 microns and about 2000 microns, and wherein the microsphere is non-resorbable within a body of a patient such that a location of the microsphere can be detected more than about 48 hours after injection into the body of the patient.