Tissue bonding insect repellent
The present disclosure generally provides topically applicable insect repelling compositions, and in some embodiments, topically applicable insect repelling and UV protecting compositions. The compositions comprise a polymerization product of a polyol, a diisocyanate and at least one insect-repelling compound. The resulting polymers advantageously bond superficially to skin or hair, thereby localizing repellents and preventing systemic absorption. While not being bound by theory, it is believed that the localization of repellents to the surface of the skin renders them safer, wherein such repellents are not vaporized and do not have a disagreeable odor. The repellents advantageously interact with tactile insect activity, thereby preventing parasitic activity, such as drawing blood or the communication of pathogens.
1. A topical insect repellent composition, comprising:
i) a poloxamer triol bound to at least one insect-repellent molecule via polymerization of a diisocyanate, and
ii) a carrier suitable for application to the skin or hair;
wherein the poloxamer triol is a polymerization product of a triol, the diisocyanate, and a poloxamer, such that the product is a polyol comprising 3 arms of poloxamer bonded to one triol;
wherein the triol is trimethylolpropane or glycerol; and
wherein the insect-repellent molecule is a compound extractable from a natural oil selected from the group consisting of neem oil, citronella oil, and lemon eucalyptus oil.
2. The composition of claim 1 , wherein the poloxamer triol is comprised of a block copolymer containing 10 to 60 carbon atoms per block.
3. The composition of claim 1 , wherein the composition comprises an NCO weight fraction of less than 20% of the total weight.
4. The composition of claim 1 , wherein the poloxamer triol is a multi-armed polymer, wherein at least one arm comprises a terminal NCO group, and at least two other arms are each bound to an insect-repellent molecule.
5. The composition of claim 4 , wherein the multi-armed poloxamer triol is a three-armed polymer.
6. The composition of claim 1 , wherein the poloxamer triol has a molecular weight between 1,000 and 20,000 Daltons.
7. The composition of claim 4 , wherein at least one arm of the poloxamer triol comprises at least one terminal NCO group capable of bonding to human skin.
8. The composition of claim 7 wherein the poloxamer triol is capable of bonding to skin via a covalent bond formed between the terminal NCO group and the skin.
9. The composition of claim 1 , wherein the poloxamer triol is further bound to an ultraviolet-absorbing compound.
10. The composition of claim 1 wherein the carrier comprises a free insect repellent and a skin emollient.
11. The composition of claim 10 , wherein the free insect repellent is selected from the group consisting of i) a synthetic insect repellent, ii) a natural insect repellent and iii) combinations thereof.
12. The composition of claim 11 , wherein the synthetic insect repellent comprises DEET.
13. A topical insect-repellent composition, comprising:
a compound comprising an insect-repellent molecule bound to a poloxamer triol, wherein the molecular weight of the compound is 500 Daltons or greater,
wherein the insect-repellent molecule is a compound extractable from a natural oil selected from the group consisting of neem oil, citronella oil, and lemon eucalyptus oil.
14. The composition of claim 13 , wherein the insect-repellent molecule is p-menthane-3,8-diol.
15. The composition of claim 13 , wherein the poloxamer triol further comprises at least one free isocyanate group.
16. The composition of claim 13 , wherein the insect-repellent molecule is picaridin.
17. The topical insect repellant composition of claim 13 , wherein the poloxamer triol is a polymerization product of: a triol selected from trimethylolpropane or glycerol, a diisocyanate, and a poloxamer.
18. The composition of claim 1 , wherein the insect-repellent molecule is a compound extracted from a natural oil selected from the group consisting of neem oil, citronella oil, and lemon eucalyptus oil.
19. The composition of claim 13 , wherein the insect-repellent molecule is a compound extracted from a natural oil selected from the group consisting of neem oil, citronella oil, and lemon eucalyptus oil.