PREVENTATIVE THERAPY FOR POST-TRAUMATIC OSTEOARTHRITIS
Compositions comprising a reverse-temperature sensitive hydrogel comprising a biopolymer such as a polysaccharide and a synthetic polymer, and a compound in an amount that reversibly inhibits respiratory enzyme complex I, and methods of using the composition, are provided.
1 . A composition comprising a reverse-temperature sensitive hydrogel comprising a polysaccharide and a synthetic polymer, and a compound that prevents or inhibits chondrocyte death or enhances chondrocyte function.
2 . The composition of claim 1 wherein the polysaccharide comprises hyaluronic acid (HA), hydroxypropylcellulose, karaya gum (KG), guar gum (GUG), or gellan gum (GEG).
3 . The composition of claim 2 wherein the hydrogel includes about 0.2 wt/vol to about 4% wt/vol HA.
4 . The composition of claim 2 wherein the HA has a MW of 1.5 M Dalton or greater.
5 . The composition of claim 2 wherein the HA has a MW of about 1,600,000 to 3,200,000.
6 . The composition of claim 1 wherein the synthetic polymer comprises a polaxamer.
7 . The composition of claim 1 wherein the compound comprises amobarbital or a derivative thereof.
8 . The composition of claim 1 wherein the compound comprises adenosine diphosphate ribose, or metformin.
9 . A method to prevent or inhibit post-traumatic osteoarthritis after injury in a mammal, comprising administering to an injured joint of the mammal an effective amount of the composition of claim 1 .
10 . The method of claim 9 wherein the mammal is a human.
11 . A method of treating articular injury in a mammal, comprising: injecting into an injured joint of a mammal an effective amount of the composition of claim 1 .