Method of manufacturing microneedle array
Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.
1. A method of manufacturing a microneedle array in which a plurality of needle-like recessed portions of a surface of a mold are filled with a liquid to form one dose of a patch having a plurality of needle-like protruding portions on a surface thereof, the method comprising:
a pre-filling measurement step of measuring a mass of the mold;
a filling step of filling the needle-like recessed portions of the mold whose mass is measured with the liquid;
a post-filling measurement step of measuring a mass of the mold filled with the liquid;
a filling amount determination step of determining a filling amount of the liquid from a difference in mass of the mold before and after the filling of the liquid;
a filling state determination step of determining a filling state of the liquid in the mold filled with the liquid;
a suction step of sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face; and
an evaporation and drying step of evaporating and drying a solvent of the liquid of the sucked mold.
2. The method of manufacturing a microneedle array according to claim 1 ,
wherein in the filling amount determination step, the filling amount is determined to be normal in a case where the difference is within a certain range.
3. The method of manufacturing a microneedle array according to claim 1 ,
wherein the liquid is a drug solution containing a drug, and
in the filling step, a position of the mold is made to coincide with a position of a drug solution jetting nozzle, and the drug solution is jetted from the drug solution jetting nozzle to be landed in the needle-like recessed portions.
4. The method of manufacturing a microneedle array according to claim 3 ,
wherein the filling step includes
a step of imaging a plurality of positions in the mold, and
a step of calculating positions of the needle-like recessed portions based on the imaged plurality of positions.
5. The method of manufacturing a microneedle array according to claim 3 ,
wherein in the filling state determination step, a captured image of the mold filled with the liquid is analyzed, and the filling state of the drug solution is determined to be normal in a case where the drug solution lands in all the needle-like recessed portions of the mold.
6. The method of manufacturing a microneedle array according to claim 3 ,
wherein the liquid is a base solution, and
in the filling step, a position of the mold is made to coincide with a position of a base solution spotting nozzle, and the needle-like recessed portion in which the drug solution filling the recessed portion is evaporated and dried is filled with the base solution by spotting.
7. The method of manufacturing a microneedle array according to claim 6 ,
wherein the mold has a thick bank portion at a peripheral portion thereof, and
in the filling state determination step, a captured image of the mold after the filling of the base solution is analyzed, and the filling state of the base solution is determined to be normal in a case where the base solution exists only in a region surrounded by the bank portion.
8. The method of manufacturing a microneedle array according to claim 1 ,
wherein the post-filling measurement step is performed before the filling state determination step.
9. The method of manufacturing a microneedle array according to claim 1 ,
wherein the mold is placed on a conveying tool, and
in the pre-filling measurement step and the post-filling measurement step, a mass of the conveying tool and the mold is measured.
10. The method of manufacturing a microneedle array according to claim 9 ,
wherein the conveying tool is provided with adsorption holes in a seating face on which the mold is placed.
11. The method of manufacturing a microneedle array according to claim 1 ,
wherein the mold has gas permeability.