Treatment of ischemia
A system, including methods and compositions, for treatment of ischemia.
1. A method of treating ischemia, comprising:
administering a therapeutically effective amount of an acid sensing ion channel 1a (ASIC1a) inhibitor to an ischemic subject in order to reduce injury resulting from ischemia, wherein the ion channel 1a (ASIC1a) inhibitor is a peptide that includes a cystine knot.
2. The method of claim 1 , wherein the step of administering includes a step of administering an ASIC1a inhibitor that inhibits ASIC1a selectively relative to one or more other acid sensing ion channel (ASIC) family members.
3. The method of claim 1 , wherein the step of administering includes a step of administering an inhibitor that is selective for ASICI a relative to every other member of the ASIC family.
4. The method of claim 1 , wherein the step of administering is performed on a subject that has suffered a stroke, in order to reduce injury resulting from the stroke.
5. The method of claim 1 , wherein the step of administering includes a step of administering the inhibitor nasally, intrathecally, and/or epidurally.
6. The method of claim 1 , wherein the step of administering includes a step of administering a peptide that is a derivative of PcTx1 (SEQ ID NO:1).
7. The method of claim 6 , wherein the peptide is a derivative that differs from PcTx1 by at least one deletion, substitution, and/or addition of one or more amino acids.
8. The method of claim 1 , the ASIC1a inhibitor being a first inhibitor, further comprising a step of administering a second inhibitor to the subject, the second inhibitor being configured to selectively inhibit at least one other channel that is not a member of the acid sensing ion channel family.
9. The method of claim 1 , wherein the step of administering includes a step of administering an inhibitor configured to inhibit ASIC1a channel activity at a concentration of inhibitor that is at least about ten-fold less than for inhibition of another ASIC family member.
10. The method of claim 1 , wherein the ischemia is stroke, and wherein the step of administering is performed at least about two hours after the onset of stroke on the ischemic subject to reduce injury induced by the stroke.