Treating inflammation with inhaled aspirin
The subject technology relates generally to pulmonary delivery of NSAIDs, such as aspirin.
1. A method of treating or reducing the risk of a thromboembolic event in a subject in need thereof, the method comprising administering by pulmonary delivery to the subject a dry powder composition from within a dry powder inhaler, wherein the dry powder composition in the inhaler before the administering is provided in a capsule or blister and comprises acetylsalicylic acid or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient and the dry powder composition comprises 95% or more by weight of acetylsalicylic acid or a pharmaceutically acceptable salt thereof, wherein the dry powder composition has a mass median aerodynamic diameter (MMAD) of less than 5 μm, and wherein the dry powder composition delivers at least 50% of administered acetylsalicylic acid or a pharmaceutically acceptable salt thereof to systemic circulation of the subject within about 15 minutes after the administering.
2. The method of claim 1 , wherein the dry powder composition delivers at least 60% of administered acetylsalicylic acid or a pharmaceutically acceptable salt thereof to systemic circulation of the subject within about 15 minutes of administration.
3. The method of claim 1 , wherein the dry powder composition delivers at least 70% of administered acetylsalicylic acid or a pharmaceutically acceptable salt thereof to systemic circulation of the subject within about 15 minutes of administration.
4. The method of claim 1 , wherein the dry powder composition delivers at least 80% of administered acetylsalicylic acid or a pharmaceutically acceptable salt thereof to systemic circulation of the subject within about 15 minutes of administration.
5. The method of claim 1 , wherein the thromboembolic event is selected from myocardial infarction, deep venous thrombosis, pulmonary embolism and thrombotic stroke.
6. The method according to claim 1 , wherein the dry powder composition does not contain lactose.
7. A method for treating or reducing the risk of a thrombotic event in a subject in need thereof, the method comprising administering by pulmonary delivery to the subject a dry powder composition from within a dry powder inhaler, wherein the dry powder composition in the inhaler before the administering is provided in a capsule or blister and comprise 95% or more by weight of acetylsalicylic acid or a pharmaceutically acceptable salt thereof, the dry powder composition has a volume median geometric diameter (VMGD) of less than 5 μm, and wherein the dry powder composition delivers at least 50% of administered acetylsalicylic acid or a pharmaceutically acceptable salt thereof to systemic circulation of the subject within about 15 minutes after the administering.
8. The method of claim 7 , wherein the dry powder composition delivers at least 60% of administered acetylsalicylic acid or a pharmaceutically acceptable salt thereof to systemic circulation of the subject within about 15 minutes of administration.
9. The method of claim 7 , wherein the dry powder composition delivers at least 70% of administered acetylsalicylic acid or a pharmaceutically acceptable salt thereof to systemic circulation of the subject within about 15 minutes of administration.
10. The method of claim 7 , wherein the dry powder composition delivers at least 80% of administered acetylsalicylic acid or a pharmaceutically acceptable salt thereof to systemic circulation of the subject within about 15 minutes of administration.
11. The method of claim 7 , wherein thromboembolic event is selected from myocardial infarction, deep venous thrombosis, pulmonary embolism and thrombotic stroke.
12. The method according to claim 7 , wherein the dry powder composition does not contain lactose.