IP Library Granted Patent US 11,085,048
Granted Patent B2
US 11,085,048 · App. 16/396,580 · Granted Aug 10, 2021

Lignification reduction in plants

Inventors: Dominique Loqué (Albany, CA); Aymerick Guillaume Eudes (Emeryville, CA)
Assignee: The Regents of the University of California
C12N15/8255C12N9/88
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Quick Facts
Patent No.
US 11,085,048
App. No.
16/396,580
Granted
Aug 10, 2021
Kind
B2
Abstract

The present invention provides an expression cassette containing a polynucleotide coding sequence for a hydroxycinnamoyl-CoA hydratase-lyase (HCHL), which is operably linked to a heterologous promoter. Also provided are methods of engineering plants that have reduced lignification, as well as cells, plant parts, and plant tissues from such engineered plants.

Claims (12)

1. A method of obtaining a plant having improved digestability as forage, the method comprising:

introducing a polynucleotide encoding a hydroxycinnamoyl-CoA hydratase-lyase (HCHL) polypeptide having at least 95% identity to SEQ ID NO:1 into a population of plants, wherein the polynucleotide is operably linked to a secondary wall-specific promoter;

culturing the population of plants under conditions in which the HCHL is expressed;

chemically analyzing the lignin monomer structure of plant cell walls; and

selecting a plant that has cell wall lignin that comprises β-O-4-linked C 6 C 1 monomer end-groups lacking phenyl propanoid tails, thereby obtaining a plant that has improved digestibility as forage compared to a counterpart wildtype plant.

2. The method of claim 1 , wherein the polypeptide comprises the amino acid sequence of SEQ ID NO:1.

3. The method of claim 1 , wherein the plant is a monocot.

4. The method of claim 1 , wherein the plant is a grass.

5. The method of claim 1 , wherein the plant is selected from the group consisting of sorghum, millet, corn, soy, barley, wheat, rice, sugarcane, bamboo, rape, sunflower, hemp, switchgrass, miscanthus, alfalfa, turfgrass, and Brachypodium.

6. A plant having improved digestibility as forage obtained by the method of claim 1 .

7. Forage material comprising the plant of claim 6 .

8. A method of improving digestion of forage material in an animal, the method comprising providing forage material of claim 7 to the animal.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jan 17, 2020
From: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
To: UNITED STATES DEPARTMENT OF ENERGY
Reel/Frame 051546/0477 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 10, 2019
From: LOQUE, DOMINIQUE; EUDES, AYMERICK GUILLAUME
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 049145/0880 →
Continuity (3)
Continuation 14232018
Provisional Application 61507484 · Jul 13, 2011
Related Publication 20190300895A1 · Oct 3, 2019