Transdermal delivery of cannabidiol with other active moieties including cannabinoids
Transdermal delivery devices for the delivery of cannabidiol (CBD) and related moieties are shown and described. In a reservoir-patch design, a microporous, hydrophilic membrane and a backing define a reservoir that houses a mixture of CBD, a polar liquid, and a gelling agent, along with other moieties that seem to be enhanced or bioavailability of increased by the same. The hydrophilic membrane is coated with an amine-compatible silicone skin adhesive. In a monolithic design, a release liner is coated with a mixture of CBD and a PIB or amine-compatible silicone skin adhesive laminated to the backing material. In using CBD as a pure compound or as one to combine with other moieties, the invention is able to control delivery better than the prior art. Construction of the transdermal patch of reservoir type is also taught, which enables things such as Vitamin B12 to become part of the complex deliverable by the inventions.
1. A method for making a monolithic cannabidiol (CBD) patch, wherein the monolithic CBD patch comprises:
a matrix comprising cannabidiol (CBD) in polyisobutylene (FIB) adhesive, and 1,2-propylene glycol;
a release liner; and
a backing film,
wherein the matrix has a first surface adhered to the backing film, and a second surface opposite the surface adhered to the backing film,
wherein the release liner is adhered to the surface of the matrix opposite the surface adhered to the backing film;
wherein the CBD is present in the matrix at concentration from 1% to 30% by weight;
wherein the CBD is dissolved in heptane or ethyl acetate; and
wherein the matrix excludes ethanol; the method comprising:
(i) dissolving CBD in 1,2-propylene glycol and mixing the dissolved CBD in 1,2-propylene into the PIB adhesive and penetration enhancers are added if needed,
(ii) dispensing the PIB adhesive mix on the release liner by means of knife-over-roll coating method and drying in an oven at drying time from 1 min to 3 min or until all residual solvents are below 1 ppm, in order to produce a dried adhesive film,
(iii) laminating the dried adhesive film to the backing film by nipping, to produce a laminate, and slitting edges for further die cutting of the patch, and
(iv) placing the laminate on a die cutting machine and cutting proper sized patch and later packaging the patch.