IP Library Granted Patent US 10,481,070
Granted Patent B2
US 10,481,070 · App. 16/398,400 · Granted Nov 19, 2019

Systems, devices, and methods for flow control and sample monitoring control

Inventors: Anthony Clint Clayton (Rougemont, NC); Howard Jerome Walls (Apex, NC); David S. Ensor (Chapel Hill, NC); Andrei Yurievich Khlystov (Chapel Hill, NC)
Assignee: Research Triangle Institute
G01N15/1404C12Q3/00G01N15/0205G01N15/06G01N15/0625G01N15/1459G01N21/53G01N21/6486G01N2015/0065G01N2015/0693G01N2015/1493G01N2201/062
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Quick Facts
Patent No.
US 10,481,070
App. No.
16/398,400
Granted
Nov 19, 2019
Kind
B2
Abstract

Sample monitoring and flow control systems and methods are disclosed for monitoring of airborne particulates. A system may include a particle collection filter. The system also includes a fluid moving device for moving a sample through the particle collection filter. Further, the system includes a light source configured to direct irradiating light towards the particle collection filter. The system also includes a light detector positioned to receive the irradiating light passing through the particle collection filter and configured to generate a signal representative of an amount of the received light. Further, the system includes a controller configured to receive the signal and to control the fluid moving device based on the amount of the received light.

Claims (25)

1. A method for sample monitoring control, the method comprising:

using a fluid moving device to move a sample through a particle collection filter positioned in a sample chamber enclosed by a housing;

collecting particles of the sample for analysis;

directing irradiating light from a light source towards the particle collection filter;

determining an amount of the irradiating light passing through the particle collection filter by a light detector comprising a photo-responsive material receiving the light emitted from the particles of the sample, wherein the photo-responsive material is flexible and conformally disposed on an inside surface or an outside surface of the housing; and

controlling the fluid moving device based on the amount of the received light.

2. The method of claim 1 , wherein the particle collection filter comprises a nanofiber filter.

3. The method of claim 1 , wherein the particle collection filter comprises a plurality of fibers.

4. The method of claim 3 , wherein fibers are formed into a fiber mat and configured to collect particles thereon.

5. The method of claim 1 , wherein the fibers have an average fiber diameter of less than 500 nanometers.

6. The method of claim 1 , wherein the housing comprises a sample inlet and sample outlet.

7. The method of claim 6 , wherein the fluid moving device and the light detector are positioned within the sample chamber, and

wherein the particle collection filter is positioned between the light detector and the light source.

8. The method of claim 1 , wherein directing the irradiating light comprises emitting the irradiating light in a wavelength range effective for inducing autofluorescence in one or more types of bioparticles.

9. The method of claim 1 , wherein directing the irradiating light comprises using a light emitting diode (LED) to emit the irradiating light.

10. The method of claim 1 , wherein controlling the fluid moving device comprises controlling the fluid moving device to one of increase and decrease a fluid moving output of the fluid moving device based on the amount of the received light.

11. The method of claim 1 , wherein controlling the fluid moving device comprises controlling the fluid moving device to increase an output of the fluid moving device in response to an increase in the amount of the received light.

12. The method of claim 1 , wherein controlling the fluid moving device comprises controlling the fluid moving device to decrease an output of the fluid moving device in response to a decrease in the amount of the received light.

13. The method of claim 1 , wherein controlling the fluid moving device comprises using one of a microcontroller, and a plurality of resistors and a voltage regulator.

14. The method of claim 1 , further comprising using the photo-responsive material for receiving measurement light from aerosol.

15. The method of claim 14 , further comprising using a data acquisition device for measuring a response of the photo-responsive material selected from the group consisting of: a voltage response; a current response; a resistance response; or a combination of two or more of the foregoing.

16. The method of claim 1 , wherein the particle collection filter has a transmittance of at least 30%.

17. The method of claim 1 , wherein the particle collection filter has a transmittance of at least 50%.

18. The method of claim 1 , wherein the particle collection filter has a filtration efficiency of at least 85%.

19. The method of claim 1 , wherein the particle collection filter has a filtration efficiency of greater than 90%.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 30, 2019
From: CLAYTON, ANTHONY CLINT; WALLS, HOWARD JEROME; ENSOR, DAVID S.; KHLYSTOV, ANDREI YURIEVICH
To: RESEARCH TRIANGLE INSTITUTE
Reel/Frame 049029/0901 →
Continuity (4)
Division 15504727
Provisional Application 62039519 · Aug 20, 2014
Provisional Application 62039512 · Aug 20, 2014
Related Publication 20190257737A1 · Aug 22, 2019