Forms of (R)-N-(4-chlorophenyl)-2-(cis-4-(6-fluoroquinolin-4- yl)cyclohexyl)propanamide
Forms B and C of (R)—N-(4-chlorophenyl)-2-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide are stable under the conditions of light, high temperature and high humidity.
1. Form B of crystalline monohydrate (R)—N-(4-chlorophenyl)-2-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide, wherein the Form B is a monoclinic crystal system, the space group is C2, the unit cell dimensions are a=25.358(9) Å, b=10.016(3) Å, c=8.788(3) Å, α=90°, β=91.57(2°), γ=90° and Z=4, and the unit cell volume is 2231.2(14) Å 3 , and a X-ray powder diffraction pattern mainly has the following characteristic peaks, wherein the X-ray powder diffraction pattern has the strongest peak when 2θ is 20.142±0.2, and has the second strongest peak when 2θ is 17.644±0.2,
Angle 2θ
6.985 ± 0.2
9.447 ± 0.2
12.398 ± 0.2
13.677 ± 0.2
17.171 ± 0.2
17.644 ± 0.2
18.985 ± 0.2
20.142 ± 0.2
21.118 ± 0.2
21.62 ± 0.2
22.199 ± 0.2
24.173 ± 0.2
24.915 ± 0.2
26.828 ± 0.2
28.682 ± 0.2
30.418 ± 0.2
31.46 ± 0.2.
2. The Form B according to claim 1 , wherein an DSC pattern has an endothermic peak at 109±2° C.;
and/or wherein there is a weight loss of between 4% and 4.2% in a TGA pattern of the Form B.