Combination blood lancet and analyzer
Methods and systems for collecting and analyzing blood are provided. The methods and systems generally operate by collecting a blood sample on a portion of a lancet and subjecting the blood sample to optical spectroscopy.
1. A method of collecting and analyzing blood, said method comprising:
cutting a skin of a subject with an optically reflective portion of a lancet;
collecting a liquid blood sample of the subject with the optically reflective portion of the lancet;
allowing the liquid blood sample to dry on the optically reflective portion of the lancet to form a dried blood sample;
passing light through the dried blood sample on the lancet; and
subjecting the dried blood sample to an optical spectroscopy by collecting the light passed through the dried blood sample and reflected off of the optically reflective portion of the lancet with an optical spectrometer for analysis of the blood sample.
2. The method of claim 1 , wherein collecting the blood sample of the subject with the lancet comprises collecting a volume of less than 10 μL of blood.
3. The method of claim 1 , wherein collecting the blood sample of the subject with the lancet comprises collecting a volume of less than 5 μL of blood.
4. The method of claim 1 , wherein collecting the blood sample of the subject with the lancet comprises collecting a volume of less than 1 μL of blood.
5. The method of claim 1 , wherein the optical spectroscopy comprises infrared spectroscopy.
6. The method of claim 1 , wherein the optical spectroscopy comprises mid-infrared spectroscopy.
7. The method of claim 1 , further comprising conducting optical spectroscopy upon a plurality of dried blood samples obtained from a plurality of subjects to obtain a plurality of dried blood spectra.
8. The method of claim 7 , further comprising constructing a model from the plurality of dried blood spectra.
9. The method of claim 8 , wherein the model is constructed using one or more multivariate least squares methods.
10. The method of claim 8 , wherein the model is constructed using an augmented classical least squares method.
11. The method of claim 8 , further comprising utilizing the model to allow predictive analysis of blood chemistry of an unknown blood sample.
12. The method of claim 1 , wherein the optically reflective portion of the lancet comprises a beveled tip.
13. The method of claim 12 , wherein the beveled tip comprises a bevel angle of less than 100 degrees.
14. The method of claim 12 , wherein the beveled tip comprises a bevel angle of less than 50 degrees.
15. The method of claim 12 , wherein the beveled tip comprises a bevel angle of less than 20 degrees.
16. The method of claim 12 , wherein the beveled tip comprises a bevel angle of less than 10 degrees.