In vivo generation of water-soluble acetylated cannabinoid glycoside compounds in plant cell suspension cultures

1. An in vivo method for the generation of water-soluble cannabinoids, comprising the steps of:

(a) establishing a tobacco cell suspension culture;

(b) introducing a cannabinoid having at least one glycosylation site to said tobacco cell suspension culture, wherein said cannabinoid is selected from the group consisting of: cannabigerol (CBG), cannabigerolic acid (CBGA), cannabidiol (CBD), and cannabidiolic acid (CBDA);

(c) incubating said cannabinoid in said tobacco cell suspension culture, thereby glycosylating the cannabinoid; and

(d) isolating a cannabinoid glycoside from said tobacco cell suspension culture, wherein said cannabinoid glycoside is selected from the group consisting of CBG-glycoside, CBD-glycoside, CBGA-glycoside and CBDA-glycoside;

wherein said tobacco cell suspension culture is a Nicotiana tabacum cell suspension culture or a Nicotiana benthamiana cell suspension culture.