IP Library Granted Patent US 11,946,059
Granted Patent B2
US 11,946,059 · App. 16/426,059 · Granted Apr 2, 2024

In vivo generation of water-soluble cannabinoids in plant cell suspension cultures

Inventors: Richard T. Sayre (Los Alamos, NM); Elton Carvalho Gonçalves (Los Alamos, NM); Tawanda Zidenga (White Rock, NM); Stephanie Willette (Santa Fe, NM)
Assignee: TRAIT BIOSCIENCES, INC.
C12N15/8257A61K31/352C12N9/0042C12N9/1051C12N15/8201C12Y106/02004C12Y204/01
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Quick Facts
Patent No.
US 11,946,059
App. No.
16/426,059
Granted
Apr 2, 2024
Kind
B2
Abstract

The present invention includes systems, methods and compositions for the in vivo bioconversion of water-soluble cannabinoids in plant cell suspension cultures.

Claims (5)

1. A method of glycosylating a cannabinoid, comprising the steps of:

(a) establishing a tobacco cell suspension culture of Nicotiana tabacum or Nicotiana benthamiana cells;

(b) introducing into said tobacco cell suspension culture a cannabinoid, wherein the cannabinoid is cannabidiol (CBD) or cannabidiolic acid (CBDA);

(c) incubating said cannabinoid in said tobacco cell suspension culture, thereby glycosylating the cannabinoid;

(d) isolating a cannabinoid glycoside from said tobacco cell suspension culture, wherein the cannabinoid glycoside is a CBD-glycoside or a CBDA-glycoside.

Assignments (6)
RELEASE OF SECURITY INTEREST Recorded Mar 24, 2021
From: GOTHAM GREEN ADMIN 1, LLC
To: TRAIT BIOSCIENCES INC., TRAIT NM INC., TRAIT BIOSCIENCES (CANADA) INC., AND TWIGG PHARMA LTD.
Reel/Frame 055705/0452 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 13, 2020
From: CARVALHO GONÇALVES, ELTON, DR.
To: TRAIT BIOSCEINCES, INC.
Reel/Frame 054626/0137 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 13, 2020
From: ZIDENGA, TAWANDA, DR.
To: TRAIT BIOSCEINCES, INC.
Reel/Frame 054626/0145 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 13, 2020
From: WILLETTE, STEPHANIE, DR.
To: TRAIT BIOSCIENCES, INC.
Reel/Frame 054626/0552 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2020
From: SAYRE, RICHARD T., DR.
To: TRAIT BIOSCEINCES, INC.
Reel/Frame 054623/0738 →
SECURITY INTEREST Recorded Jun 26, 2020
From: TRAIT BIOSCIENCES INC.; TRAIT NM INC.; TRAIT BIOSCIENCES (CANADA) INC.; TWIGG PHARMA LTD.
To: GOTHAM GREEN ADMIN 1, LLC
Reel/Frame 053057/0852 →
Continuity (7)
Continuation In Part 16110954 · Aug 23, 2018
Continuation In Part PCTUS2018041710 · Jul 11, 2018
Continuation In Part PCTUS2018024409 · Mar 26, 2018
Provisional Application 62531123 · Jul 11, 2017
Provisional Application 62588662 · Nov 20, 2017
Provisional Application 62621166 · Jan 24, 2018
Related Publication 20190316144A1 · Oct 17, 2019