Methods of Using Metamizole for Treatment of Pyrexia in Equines
Methods for treating pyrexia and other diseases in equines involving administering a parenteral formulation containing metamizole are disclosed.
1 . A method for treating an equine with pyrexia, said method comprising administering a therapeutically effective dose of metamizole to said equine, wherein the administration is repeated at least once after an interval of 12 hours.
2 . The method of claim 1 , wherein said dose is in the range of 20 mg metamizole per kg of equine subject weight (mg/kg) to 50 mg/kg.
3 . The method of claim 2 , wherein said dose is 30 mg metamizole per kg of equine subject weight (mg/kg).
4 . The method of claim 1 , wherein the metamizole is administered twice a day for at least 2 days.
5 . The method of claim 1 , wherein the metamizole is administered no more than 18 times in a period of 9 days.
6 . The method of claim 1 , wherein the dose is administered intramuscularly, intravenously (IV), or subcutaneously.
7 . The method of claim 6 , wherein the dose is administered intravenously.
8 . The method of claim 1 , wherein the metamizole is comprised within a pharmaceutical formulation.
9 . The method of claim 8 , wherein the concentration of metamizole in the pharmaceutical formulation is from 200 mg/ml to 750 mg/ml.
10 . The method of claim 9 , wherein the concentration of metamizole in the pharmaceutical formulation is from 400 mg/ml to 600 mg/ml.
11 . The method of claim 10 , wherein the concentration of metamizole in the pharmaceutical formulation is 500 mg/ml.
12 . The method of claim 1 , wherein the metamizole is metamizole sodium monohydrate.
13 . The method of claim 1 , wherein the pyrexia is due to a condition selected from viral infections, bacterial infections, parasitic infections, respiratory infections, tick-borne infections, mosquito-borne infections, equine encephalomyelitis, equine influenza, equine herpes virus, West Nile virus, strangles, Potomac horse fever, colic, post-vaccination reactions, physical trauma, and stress.
14 . A method of treating pyrexia in an equine via a dosage regimen comprising administering metamizole to the equine in the range of 20 mg metamizole per kg of equine subject weight (mg/kg) to 50 mg/kg, at a dosing interval of no more than twice daily.
15 . The method of claim 14 , wherein the metamizole is administered in an amount of 30 mg/kg no more than twice daily.
16 . The method of claim 14 , wherein the dose is administered intramuscularly, intravenously (IV), or subcutaneously.
17 . The method of claim 16 , wherein the dose is administered intravenously.
18 . The method of claim 14 , wherein the metamizole is administered to the equine for at least 2 days.
19 . (canceled)
20 . The method of claim 14 , wherein the metamizole is comprised within a pharmaceutical formulation.
21 . (canceled)
22 . The method of claim 20 , wherein the concentration of metamizole in the pharmaceutical formulation is from 400 mg/ml to 600 mg/ml.
23 . The method of claim 22 , wherein the concentration of metamizole in the pharmaceutical formulation is 500 mg/ml.
24 . The method of claim 14 , wherein the metamizole is metamizole sodium monohydrate.
25 . The method of claim 14 , wherein the pyrexia is due to a condition selected from viral infections, bacterial infections, parasitic infections, respiratory infections, tick-borne infections, mosquito-borne infections, equine encephalomyelitis, equine influenza, equine herpes virus, West Nile virus, strangles, Potomac horse fever, colic, post-vaccination reactions, physical trauma, and stress.