Fused thiophene compounds

1. A compound of Formula (I):

or a pharmaceutically acceptable salt thereof, wherein:

one of Q 1 , Q 2 , and Q 3 is S; one of Q 1 , Q 2 , and Q 3 is CR 1 ; and one of Q 1 , Q 2 , and Q 3 is CR 2 ;

each is a carbon-carbon single bond, a carbon-carbon double bond, or a carbon-sulfur single bond;

R 1 is H, deuterium, hydroxyl, halogen, cyano, nitro, optionally substituted C 1 -C 6 alkoxy, optionally substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 1 -C 6 haloalkoxy, optionally substituted amino, C 1 -C 6 alkylamino, amino(C 1 -C 6 alkyl), (C 1 -C 6 alkoxy)C 1 -C 6 alkyl, —O—(C 1 -C 6 alkoxy)C 1 -C 6 alkyl, or optionally substituted C 3 -C 8 carbocyclyl;

R 2 is

wherein each X B is independently O, S, or NR 5E ; each R 5A , R 5B , R 5C , R 5D , and R 5E is independently H, deuterium, halogen, C 1 to C 6 alkyl, or C 1 -C 6 haloalkyl; and each m1 and m2 is an integer of 1;

R 3 is H, deuterium, optionally substituted C 1 -C 6 alkyl,

X is C═O, CHR 4A , or CR 4A R 4B ;

each R 4A and R 4B is independently H, deuterium, or C 1 -C 6 alkyl;

X 1 is H, deuterium, fluoro, or C 1 -C 6 alkyl;

n is an integer of 0, 1, or 2;

each R 6 is independently C 6 -C 10 aryl or 5 to 10 membered heteroaryl, each of which is substituted with one or more substituents, each substituent independently selected from the group consisting of halogen, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkylamino, amino(C 1 -C 6 alkyl), C 3 -C 7 cycloalkyl optionally substituted with one or more R 9 , C 3 -C 7 cycloalkyl(C 1 -C 6 alkyl) optionally substituted with one or more R 9 , heterocyclyl optionally substituted with one or more R 9 , and heterocyclyl(C 1 -C 6 alkyl) optionally substituted with one or more R 9 ;

each R 9 is independently C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halogen, or cyano; or two geminal R 9 form oxo (═O); and

each of R 10 , R 11 , R 12 , R 13 , R 14 , and R 15 is independently H, optionally substituted C 1 -C 6 alkyl, or C 3 -C 6 cycloalkyl; or R 14 and R 15 together with the nitrogen atom to which they are attached form optionally substituted 5 or 6 membered heterocyclyl.

2. The compound of claim 1 , wherein the compound is a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), or (If):

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 2 , wherein n is an integer of 1.

4. The compound of claim 2 , wherein X 1 is CH 2 .

5. The compound of claim 2 , wherein X 1 is H.

6. The compound of claim 2 , wherein R 3 is H.

7. The compound of claim 2 , wherein R 2 is

wherein X B is O or NR 5E .

8. The compound of claim 2 , wherein R 2 is

wherein X B is O or NR 5E .

9. The compound of claim 2 , wherein R 2 is

wherein X B is O or NR 5E .

10. The compound of claim 7 , wherein each of R 5A , R 5B , R 5C , and R 5D is hydrogen, or at least one of R 5A , R 5B , R 5C , and R 5D is halogen or C 1 -C 6 alkyl; and wherein R 5E is H or methyl.

11. The compound of claim 8 , wherein each of R 5A , R 5B , R 5C , and R 5D is hydrogen, or at least one of R 5A , R 5B , R 5C , and R 5D is halogen or C 1 -C 6 alkyl; and wherein R 5E is H or methyl.

12. The compound of claim 9 , wherein each of R 5A , R 5B , R 5C , and R 5D is H, or at least one of R 5A , R 5B , R 5C , and R 5D is halogen or C 1 -C 6 alkyl; and wherein R 5E is H or methyl.

13. The compound of claim 2 , wherein R 1 is H.

14. The compound of claim 2 , wherein R 6 is C 6 -C 10 aryl, which is optionally substituted with one or more substituents, each substituent independently selected from the group consisting of halogen, hydroxyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkylamino, amino(C 1 -C 6 alkyl), C 3 -C 7 cycloalkyl optionally substituted with one or more R 9 , C 3 -C 7 cycloalkyl(C 1 -C 6 alkyl) optionally substituted with one or more R 9 , heterocyclyl optionally substituted with one or more R 9 , and heterocyclyl(C 1 -C 6 alkyl) optionally substituted with one or more R 9 .

15. The compound of claim 2 , wherein R 6 is phenyl or pyridyl, each of which is substituted with one, two, or three substituents, each substituent independently selected from the group consisting of halogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 alkylamino, amino(C 1 -C 6 alkyl), C 3 -C 7 cycloalkyl optionally substituted with one or more R 9 , C 3 -C 7 cycloalkyl(C 1 -C 6 alkyl) optionally substituted with one or more R 9 , 5 or 6 membered heterocyclyl optionally substituted with one or more R 9 , and 5 or 6 membered heterocyclyl(C 1 -C 6 alkyl) optionally substituted with one or more R 9 .

16. The compound of claim 15 , wherein R 6 is phenyl substituted with

each of which is optionally substituted with one or more R 9 .

17. The compound of claim 16 , wherein each R 9 is independently halogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl.

18. The compound of claim 15 , wherein R 6 is phenyl substituted with —NH(C 1 -C 4 alkyl), —N(C 1 -C 4 alkyl) 2 , —(CH 2 ) 1-3 —NH(C 1 -C 4 alkyl), or —(CH 2 ) 1-3 —N(C 1 -C 4 alkyl) 2 .

19. The compound of claim 15 , wherein R 6 is phenyl substituted with one, two, or three substituents, each substituent independently selected from the group consisting of fluoro, chloro, methyl, ethyl, n-propyl, isopropyl, t-butyl, trifluoromethyl, —NH(Me), —NH(Et), —N(Me) 2 , —N(Et) 2 ,

20. A compound of:

or a pharmaceutically acceptable salt thereof.

21. A pharmaceutical composition, comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient.

22. The compound of claim 1 , wherein the compound is a compound of Formula (Ie):

or a pharmaceutically acceptable salt thereof.

23. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

24. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

25. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

26. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

27. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

28. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

29. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

30. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

31. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

32. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

33. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

34. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

35. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

36. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

37. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

38. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

39. The compound of claim 22 , wherein the compound is

or a pharmaceutically acceptable salt thereof.