IP Library › Granted Patent US 10,959,961

Granted Patent B2

US 10,959,961 · App. 16/440,889 · Granted Mar 30, 2021

Methods of administering anionic cannabinoid molecules dissolved in water

Inventor: Douglas G. Metcalf (Erie, CO)

Assignee: Natural Extraction Systems, LLC

A61K31/05 A61J1/00 A61K9/0095 A61K47/02 A61K47/10

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Quick Facts

Patent No.: US 10,959,961
App. No.: 16/440,889
Granted: Mar 30, 2021
Kind: B2

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Abstract

Various aspects of this patent document relate to methods to administer compositions comprising anionic cannabinoid molecules.

Claims (76)

1. A method of consuming a cannabinoid, comprising:

providing a composition comprising an anionic cannabinoid molecule dissolved in water, in which the composition has a color;

contacting the composition with a Brønsted acid, in which contacting the composition with the Brønsted acid changes the color to either a different color or no color; and

consuming the composition after contacting the composition with the Brønsted acid, in which a human being consumes the composition by drinking it,

wherein the anionic cannabinoid molecule is selected from the group consisting of:

2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate;

2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-3-hydroxy-5-pentylphenolate;

2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentyl-1,4-benzoquinone-3-oxide;

3-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-6-pentyl-1,2-benzoquinone-4-oxide;

2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-5-pentyl-1,4-benzoquinone-3-oxide;

3-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-6-pentyl-1,2-benzoquinone-4-oxide;

(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-oxide;

(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-oxide;

2-[(2E)-3,7-dimethylocta-2,6-dienyl]-3-hydroxy-5-pentylphenolate;

2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-propylphenolate;

2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-3-hydroxy-5-propylphenolate;

2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-propyl-1,4-benzoquinone-3-oxide;

3-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-6-propyl-1,2-benzoquinone-4-oxide;

2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-5-propyl-1,4-benzoquinone-3-oxide;

3-(1R,6R)-6-isopropenyl-3-methylcyclohex-3-en-1-yl]-6-propyl-1,2-benzoquinone-4-oxide;

(6aR,10aR)-6,6,9-trimethyl-3-propyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-oxide;

(6aR,10aR)-6,6,9-trimethyl-3-propyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-oxide; and

2-[(2E)-3,7-dimethylocta-2,6-dienyl]-3-hydroxy-5-propylphenolate.

2. The method of claim 1 , in which the anionic cannabinoid molecule is 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate.

3. The method of claim 1 , comprising providing a hermetically-sealed container that contains the composition and unsealing the container to provide the composition.

4. The method of claim 3 , in which the hermetically-sealed container contains 25 milliliters to 800 milliliters of the composition.

5. The method of claim 3 , in which the composition comprises 50 micrograms to 500 milligrams of the anionic cannabinoid molecule.

6. The method of claim 3 , in which the hermetically-sealed container is a glass bottle, plastic bottle, or aluminum can.

7. The method of claim 3 , in which:

the hermetically-sealed container is physically associated with a label;

the label comprises an image of a reference color; and

the method comprises comparing the color of the anionic cannabinoid molecule dissolved in water to the reference color to either confirm the identity of the anionic cannabinoid molecule or confirm the approximate concentration of the anionic cannabinoid molecule in the composition.

8. The method of claim 1 , in which the color is purple.

9. The method of claim 1 , in which the composition has a pH, and the pH is 8.5 to 10.5.

10. The method of claim 1 , in which the composition comprises ethanol at a concentration of 5 parts per million to 500 parts per million by weight.

11. The method of claim 1 , in which the composition comprises a concentration of molecular oxygen, and the concentration of molecular oxygen is less than 50 micromolar.

12. The method of claim 11 , in which the composition comprises a concentration of molecular nitrogen, and the concentration of molecular nitrogen is less than 100 micromolar.

13. The method of claim 1 , comprising providing a hermetically-sealed container containing the composition and unsealing the container to provide the composition, in which:

the hermetically-sealed container is a glass bottle, plastic bottle, or aluminum can;

the container contains 25 milliliters to 800 milliliters of the composition;

the composition comprises 50 micrograms to 500 milligrams of the anionic cannabinoid molecule;

the composition has a pH; and

the pH of the composition is 8.5 to 10.5.

14. A method of consuming a cannabinoid, comprising:

providing a hermetically-sealed container that contains a composition, in which:

the hermetically-sealed container is a glass bottle, plastic bottle, or aluminum can; the container contains 25 milliliters to 800 milliliters of the composition; the composition comprises water and 50 micrograms to 500 milligrams of an anionic cannabinoid molecule; the anionic cannabinoid molecule is dissolved in the water; and the composition has a color;

unsealing the container;