IP Library › Granted Patent US 10,669,272

Granted Patent B2

US 10,669,272 · App. 16/452,679 · Granted Jun 2, 2020

Substituted naphthyridinone compounds useful as T cell activators

Inventors: Upender Velaparthi (Princeton Junction, NJ); Louis S. Chupak (Old Saybrook, CT); Chetan Padmakar Darne (Ewing, NJ); Min Ding (Stow, MA); Robert G. Gentles (Killingworth, CT); Yazhong Huang (Wallingford, CT); Manjunatha Narayana Rao Kamble (Bangalore, IN); Scott W. Martin (Middletown, CT); Raju Mannoori (Bangalore, IN); Ivar M. McDonald (Woodstock, CT); Richard E. Olson (Cambridge, MA); Hasibur Rahaman (Bangalore, IN); Prasada Rao Jalagam (Bangalore, IN); Saumya Roy (Bangalore, IN); Gopikishan Tonukunuru (Bangalore, IN); Sivasudar Velaiah (Hosur, IN); Jayakumar Sankara Warrier (Bangalore, IN); Xiaofan Zheng (Cheshire, CT); John S. Tokarski (Princeton, NJ); Bireshwar Dasgupta (Doylestown, PA); Kotha Rathnakar Reddy (Warangal West, IN); Thiruvenkadam Raja (Hosur, IN)

Assignee: Bristol-Myers Squibb Company

C07D471/04

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Quick Facts

Patent No.: US 10,669,272
App. No.: 16/452,679
Granted: Jun 2, 2020
Kind: B2

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Abstract

Disclosed are compounds of Formula (I): or a salt thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

Claims (955)

1. A compound of Formula (I):

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is H, F, Cl, Br, —CN, C 1-3 alkyl substituted with zero to 4 R 1a , C 3-4 cycloalkyl substituted with zero to 4 R 1a , C 1-3 alkoxy substituted with zero to 4 R 1a , —NR a R a , —S(O) n R e , or —P(O)R e R e ;

each R 1a is independently F, Cl, —CN, —OH, —OCH 3 , or —NR a R a ;

each R a is independently H or C 1-3 alkyl;

each R e is independently C 3-4 cycloalkyl or C 1-3 alkyl substituted with zero to 4 R 1a ;

R 2 is H, C 1-3 alkyl substituted with zero to 4 R 2a , or C 3-4 cycloalkyl substituted with zero to 4 R 2a ;

each R 2a is independently F, Cl, —CN, —OH, —O(C 1-2 alkyl), C 3-4 cycloalkyl, C 3-4 alkenyl, or C 3-4 alkynyl;

R 3 is H, F, Cl, Br, —CN, C 1-3 alkyl, C 1-2 fluoroalkyl, C 3-4 cycloalkyl, C 3-4 fluorocycloalkyl, or —NO 2 ;

R 4 is —CH 2 R 4a , —CH 2 CH 2 R 4a , —CH 2 CHR 4a R 4d , —CHR 4a R 4b , or —CR 4a R 4b R 4c ;

R 4a and R 4b are independently:

(i) C 1-6 alkyl substituted with zero to 4 substituents independently selected from F, Cl, —CN, —OH, —OCH 3 , —SCH 3 , C 1-3 fluoroalkoxy, —NR a R a , —S(O) 2 R e , or —NR a S(O) 2 R e ;

(ii) C 3-6 cycloalkyl, monocyclic heterocyclyl having 1 to 3 heteroatoms independently selected from O, S, and N, phenyl, 5- or 6-membered monocyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, or 9- or 10-membered bicyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, each substituted with zero to 4 substituents independently selected from F, Cl, Br, —CN, —OH, C 1-6 alkyl, C 1-3 fluoroalkyl, C 1-4 hydroxyalkyl, —(CH 2 ) 1-2 O(C 1-3 alkyl), C 1-4 alkoxy, —O(C 1-4 hydroxyalkyl), —O(CH) 1-3 O(C 1-3 alkyl), C 1-3 fluoroalkoxy, —O(CH) 1-3 NR c R c , —OCH 2 CH═CH 2 , —OCH 2 C≡CH, —C(O)(C 1-4 alkyl), —C(O)OH, —C(O)O(C 1-4 alkyl), —NR c R c , —NR a S(O) 2 (C 1-3 alkyl), —NR a C(O)(C 1-3 alkyl), —NR a C(O)O(C 1-4 alkyl), —P(O)(C 1-3 alkyl) 2 , —S(O) 2 (C 1-3 alkyl), —O(CH 2 ) 1-2 (C 3-6 cycloalkyl), —O(CH 2 ) 1-2 (morpholinyl), cyclopropyl, cyanocyclopropyl, methylazetidinyl, acetylazetidinyl, (tert-butoxycarbonyl)azetidinyl, triazolyl, tetrahydropyranyl, morpholinyl, thiophenyl, methylpiperidinyl, and R d ; or

(iii) C 1-4 alkyl substituted with one cyclic group selected from C 3-6 cycloalkyl, monocyclic heterocyclyl having 1 to 3 heteroatoms independently selected from O, S, and N, aryl, 5- or 6-membered monocyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, and 9- or 10-membered bicyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, said cyclic group substituted with zero to 3 substituents independently selected from F, Cl, Br, —OH, —CN, C 1-6 alkyl, C 1-3 fluoroalkyl, C 1-3 alkoxy, C 1-3 fluoroalkoxy, —OCH 2 CH═CH 2 , —OCH 2 C≡CH, —NR c R c , —NR a S(O) 2 (C 1-3 alkyl), —NR a C(O)(C 1-3 alkyl), —NR a C(O)O(C 1-4 alkyl), and C 3-6 cycloalkyl;

or R 4a and R 4b together with the carbon atom to which they are attached form a C 3-6 cycloalkyl or a 3- to 6-membered heterocyclyl having 1 to 3 heteroatoms independently selected from O, S, and N, each substituted with zero to 3 R f ;

each R f is independently F, Cl, Br, —OH, —CN, C 1-6 alkyl, C 1-3 fluoroalkyl, C 1-3 alkoxy, C 1-3 fluoroalkoxy, —OCH 2 CH═CH 2 , —OCH 2 C≡CH, —NR c R c , or a cyclic group selected from C 3-6 cycloalkyl, 3- to 6-membered heterocyclyl having 1 to 3 heteroatoms independently selected from O, S, and N, phenyl, 5- or 6-membered monocyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, and 9- or 10-membered bicyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, each cyclic group substituted with zero to 3 substituents independently selected from F, Cl, Br, —OH, —CN, C 1-6 alkyl, C 1-3 fluoroalkyl, C 1-3 alkoxy, C 1-3 fluoroalkoxy, and —NR c R c ;

R 4c is C 1-6 alkyl or C 3-6 cycloalkyl, each substituted with zero to 4 substituents independently selected from F, Cl, —OH, C 1-2 alkoxy, C 1-2 fluoroalkoxy, and —CN;

R 4d is —OCH 3 ;

each R e is independently H or C 1-2 alkyl;

R d is phenyl substituted with zero to 1 substituent selected from F, Cl, —CN, —CH 3 , and —OCH 3 ;

each R 5 is independently —CN, C 1-6 alkyl substituted with zero to 4 R g , C 2-4 alkenyl substituted with zero to 4 R g , C 2-4 alkynyl substituted with zero to 4 R g , C 3-4 cycloalkyl substituted with zero to 4 R g , phenyl substituted with zero to 4 R g , oxadiazolyl substituted with zero to 3 R g , pyridinyl substituted with zero to 4 R g , —(CH 2 ) 1-2 (heterocyclyl having 1 to 3 heteroatoms independently selected from O, S, and N, substituted with zero to 4 R g ), —(CH 2 ) 1-2 NR c C(O)(C 1-4 alkyl), —(CH 2 ) 1-2 NR c C(O)O(C 1-4 alkyl), —(CH 2 ) 1-2 NR c S(O) 2 (C 1-4 alkyl), —C(O)(C 1-4 alkyl), —C(O)OH, —C(O)O(C 1-4 alkyl), —C(O)O(C 3-4 cycloalkyl), —C(O)NR a R a , or —C(O)NR a (C 3-4 cycloalkyl);

each R g is independently F, Cl, —CN, —OH, C 1-3 alkoxy, C 1-3 fluoroalkoxy, —O(CH 2 ) 1-2 O(C 1-2 alkyl), or —NR c R c ;

m is 1, 2, or 3; and

n is zero, 1, or 2.

2. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein:

R 1 is H, F, Cl, Br, —CN, C 1-3 alkyl substituted with zero to 4 R 1a , cyclopropyl substituted with zero to 3 R 1a , C 1-3 alkoxy substituted with zero to 3 R 1a , —NR a R a , —S(O) n CH 3 , or —P(O)(CH 3 ) 2 ;

each R 1a is independently F, Cl, or —CN;

each R a is independently H or C 1-3 alkyl;

R 2 is H or C 1-2 alkyl substituted with zero to 2 R 2a ;

each R 2a is independently F, Cl, —CN, —OH, —O(C 1-2 alkyl), cyclopropyl, C 3-4 alkenyl, or C 3-4 alkynyl;

R 3 is H, F, Cl, Br, —CN, C 1-2 alkyl, —CF 3 , cyclopropyl, or —NO 2 ;

R 4a and R 4b are independently:

(i) C 1-4 alkyl substituted with zero to 4 substituents independently selected from F, Cl, —CN, —OH, —OCH 3 , —SCH 3 , C 1-3 fluoroalkoxy, and —NR a R a ;

(ii) C 3-6 cycloalkyl, monocyclic heterocyclyl having 1 to 3 heteroatoms independently selected from O, S, and N, phenyl, 5- or 6-membered monocyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, or 9- or 10-membered bicyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, each substituted with zero to 4 substituents independently selected from F, Cl, Br, —CN, —OH, C 1-6 alkyl, C 1-3 fluoroalkyl, —CH 2 OH, —(CH 2 ) 1-2 O(C 1-2 alkyl), C 1-4 alkoxy, —O(C 1-4 hydroxyalkyl), —O(CH) 1-2 O(C 1-2 alkyl), C 1-3 fluoroalkoxy, —O(CH) 1-2 NR c R c , —OCH 2 CH═CH 2 , —OCH 2 C≡CH, —C(O)(C 1-4 alkyl), —C(O)OH, —C(O)O(C 1-4 alkyl), —NR c R c , —NR a S(O) 2 (C 1-3 alkyl), —NR a C(O)(C 1-3 alkyl), —NR a C(O)O(C 1-4 alkyl), —P(O)(C 1-2 alkyl) 2 , —S(O) 2 (C 1-3 alkyl), —O(CH 2 ) 1-2 (C 3-4 cycloalkyl), —O(CH 2 ) 1-2 (morpholinyl), cyclopropyl, cyanocyclopropyl, methylazetidinyl, acetylazetidinyl, (tert-butoxycarbonyl)azetidinyl, triazolyl, tetrahydropyranyl, morpholinyl, thiophenyl, methylpiperidinyl, and R d ; or

(iii) C 1-3 alkyl substituted with one cyclic group selected from C 3-6 cycloalkyl, monocyclic heterocyclyl having 1 to 3 heteroatoms independently selected from O, S, and N, phenyl, 5- or 6-membered monocyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, and 9- or 10-membered bicyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, said cyclic group substituted with zero to 3 substituents independently selected from F, Cl, Br, —OH, —CN, C 1-3 alkyl, C 1-2 fluoroalkyl, C 1-3 alkoxy, C 1-2 fluoroalkoxy, —OCH 2 CH═CH 2 , —OCH 2 C≡CH, —NR c R c , —NR a S(O) 2 (C 1-3 alkyl), —NR a C(O)(C 1-3 alkyl), —NR a C(O)O(C 1-4 alkyl), and C 3-4 cycloalkyl;

or R 4a and R 4b together with the carbon atom to which they are attached, form a C 3-6 cycloalkyl or a 3- to 6-membered heterocyclyl having 1 to 3 heteroatoms independently selected from O, S, and N, each substituted with zero to 3 R f ;

each R f is independently F, Cl, Br, —OH, —CN, C 1-4 alkyl, C 1-2 fluoroalkyl, C 1-3 alkoxy, C 1-2 fluoroalkoxy, —OCH 2 CH═CH 2 , —OCH 2 C≡CH, —NR c R c , or a cyclic group selected from C 3-6 cycloalkyl, 3- to 6-membered heterocyclyl having 1 to 3 heteroatoms independently selected from O, S, and N, phenyl, 5- or 6-membered monocyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, and 9- or 10-membered bicyclic heteroaryl having 1, 2, or 3 heteroatoms independently selected from O, S, and/or N, each cyclic group substituted with zero to 3 substituents independently selected from F, Cl, Br, —OH, —CN, C 1-4 alkyl, C 1-2 fluoroalkyl, C 1-3 alkoxy, C 1-2 fluoroalkoxy, and —NR c R c ;

R 4c is C 1-4 alkyl or C 3-6 cycloalkyl, each substituted with zero to 4 substituents independently selected from F, Cl, —OH, C 1-2 alkoxy, C 1-2 fluoroalkoxy, and —CN;

and each R 5 is independently —CN, C 1-5 alkyl substituted with zero to 4 R g , C 2-3 alkenyl substituted with zero to 4 R g , C 2-3 alkynyl substituted with zero to 4 R g , C 3-4 cycloalkyl substituted with zero to 4 R g , phenyl substituted with zero to 3 R g , oxadiazolyl substituted with zero to 3 R g , pyridinyl substituted with zero to 3 R g , —(CH 2 ) 1-2 (heterocyclyl having 1 to 3 heteroatoms independently selected from O, S, and N, substituted with zero to 4 R g ), —(CH 2 ) 1-2 NR c C(O)(C 1-4 alkyl), —(CH 2 ) 1-2 NR c C(O)O(C 1-4 alkyl), —(CH 2 ) 1-2 NR c S(O) 2 (C 1-4 alkyl), —C(O)(C 1-4 alkyl), —C(O)OH, —C(O)O(C 1-4 alkyl), —C(O)O(C 3-4 cycloalkyl), —C(O)NR a R a , or —C(O)NR a (C 3-4 cycloalkyl).

3. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein:

R 1 is H, Cl, Br, —CN, or —OCH 3 ;

R 2 is —CH 3 ;

R 3 is H, F, Cl, Br, —CN, —CH 3 , cyclopropyl, or —NO 2 ;

R 4 is —CH 2 R 4a , —CH 2 CH 2 R 4a , —CH 2 CHR 4a R 4d , or —CHR 4a R 4b ;

R 4a is phenyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrazolyl, imidazolyl, isoxazolyl, isothiazolyl, oxazolyl, oxadiazolyl, tetrazolyl, thiadiazolyl, thiazolyl, triazolyl, thiophenyl, tetrahydropyranyl, dihydrobenzo[b][1,4]dioxinyl, dihydrobenzo[b][1,4]dioxepinyl, dihydrobenzofuranyl, benzo[d]isoxazolyl, benzoxazinyl, benzoxazinonyl, indazolyl, indolyl, benzo[d][1,3]dioxolyl, pyrazolo[1,5-a]pyridinyl, dioxidotetrahydrothiopyranyl, quinolinyl, or naphthyridinyl, each substituted with zero to 3 substituents independently selected from F, Cl, Br, —CN, —OH, —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —C(CH 3 ) 3 , —CHF 2 , —CF 3 , —CH 2 OH, —CH 2 OCH 3 , —OCH 3 , —OCH 2 CH 3 , —OCH(CH 3 ) 2 , —OC(CH 3 ) 3 , —OCH 2 C(CH 3 ) 2 OH, —OCH 2 CH 2 OCH 3 , —OCHF 2 , —OCF 3 , —OCH 2 CH 2 N(CH 3 ) 2 , —C(O)CH 3 , —C(O)C(CH 3 ) 3 , —C(O)OH, —C(O)OCH 3 , —C(O)OC(CH 3 ) 3 , —N(CH 3 ) 2 , —P(O)(CH 3 ) 2 , —S(O) 2 CH 3 , —OCH 2 (cyclopropyl), —OCH 2 CH 2 (cyclopropyl), —OCH 2 CH 2 (morpholinyl), cyclopropyl, cyanocyclopropyl, methylazetidinyl, acetylazetidinyl, (tert-butoxycarbonyl)azetidinyl, triazolyl, tetrahydropyranyl, morpholinyl, phenyl, fluorophenyl, cyanophenyl, thiophenyl, fluorophenyl, and methylpiperidinyl;

R 4b is:

(i) —CH 3 , —CH 2 CH 3 , —CH 2 CH 2 CH 3 , —C(CH 3 ) 3 , —CH 2 F, —CF 3 , —CH 2 OH, —C(CH 3 ) 2 OH, —CH 2 OCH 3 , —CH 2 OCHF 2 , —CF 2 CH 2 OH, —CF 2 CH 2 OCH 3 , —CH 2 SCH 3 , cyclopropyl, —CH 2 (cyclohexyl), or —CH 2 (cyclopropyl-oxadiazolyl); or

(ii) phenyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrazolyl, imidazolyl, isoxazolyl, isothiazolyl, oxazolyl, oxadiazolyl, tetrazolyl, thiadiazolyl, thiazolyl, triazolyl, thiophenyl, tetrahydropyranyl, dihydrobenzo[b][1,4]dioxinyl, dihydrobenzo[b][1,4]dioxepinyl, dihydrobenzofuranyl, benzo[d]isoxazolyl, benzoxazinyl, benzoxazinonyl, indazolyl, indolyl, benzo[d][1,3]dioxolyl, pyrazolo[1,5-a]pyridinyl, dioxidotetrahydrothiopyranyl, quinolinyl, or naphthyridinyl, each substituted with zero to 3 substituents independently selected from F, Cl, Br, —CN, —OH, —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —C(CH 3 ) 3 , —CHF 2 , —CF 3 , —CH 2 OH, —CH 2 OCH 3 , —OCH 3 , —OCH 2 CH 3 , —OCH(CH 3 ) 2 , —OC(CH 3 ) 3 , —OCH 2 C(CH 3 ) 2 OH, —OCH 2 CH 2 OCH 3 , —OCHF 2 , —OCF 3 , —OCH 2 CH 2 N(CH 3 ) 2 , —C(O)CH 3 , —C(O)C(CH 3 ) 3 , —C(O)OH, —C(O)OCH 3 , —C(O)OC(CH 3 ) 3 , —N(CH 3 ) 2 , —P(O)(CH 3 ) 2 , —S(O) 2 CH 3 , —OCH 2 (cyclopropyl), —OCH 2 CH 2 (cyclopropyl), —OCH 2 CH 2 (morpholinyl), cyclopropyl, cyanocyclopropyl, methylazetidinyl, acetylazetidinyl, (tert-butoxycarbonyl)azetidinyl, triazolyl, tetrahydropyranyl, morpholinyl, phenyl, fluorophenyl, cyanophenyl, thiophenyl, fluorophenyl, and methylpiperidinyl;

or R 4a and R 4b together with the carbon atom to which they are attached form cyclopropyl substituted with fluorophenyl;

each R 5 is independently —CN, —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —CH 2 F, —C(CH 3 ) 2 F, —CF(CH 3 )CH(CH 3 ) 2 , —CH 2 CN, —CH 2 OH, —C(CH 3 ) 2 OH, —C(CH 3 )(OH)CH(CH 3 ) 2 , —CH 2 OCH 3 , —CH 2 OCH 2 CH 3 , —CH 2 OCHF 2 , —CH 2 OCH 2 CH 2 OCH 3 , —CH 2 N(CH 3 ) 2 , —CH 2 NHC(O)CH 3 , —CH 2 NHC(O)OCH 3 , —CH 2 NHS(O) 2 CH 3 , —C(O)C(CH 3 ) 2 , —CH 2 (hydroxyazetidinyl), —CH 2 (morpholinyl), —CH 2 (methylpiperazinyl), —C(O)OH, —C(O)OCH 3 , —C(O)OC(CH 3 ) 2 , —C(O)NH 2 , —C(O)NH(cyclopropyl), —C(O)O(cyclopropyl), cyclopropyl, phenyl, methyloxadiazolyl, or methylpyridinyl; and

m is 1 or 2.

4. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein:

R 4 is —CH 2 R 4a , —CD 2 R 4a , or —CH 2 CH 2 R 4a ; and

R 4a is phenyl, pyridinyl, tetrahydropyranyl, benzoxazinyl, benzo[d][1,3]dioxolyl, benzoxazinonyl, indazolyl, indolyl, or quinolinyl, each substituted with zero to 3 substituents independently selected from F, Cl, Br, —CN, —OH, —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —C(CH 3 ) 3 , —CHF 2 , —CF 3 , —OCH 3 , —OCH 2 CH 3 , —OCH(CH 3 ) 2 , —OCHF 2 , —OCF 3 , —C(O)CH 3 , —C(O)OC(CH 3 ) 3 , —N(CH 3 ) 2 , cyanocyclopropyl, and phenyl.

5. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein:

R 4 is —CHR 4a R 4b , —CDR 4a R 4b , or —CH 2 CHR 4a R 4d ;

R 4a is phenyl, pyridinyl, dihydrobenzofuranyl, benzodioxolyl, isoxazolyl, naphthyridinyl, quinolinyl, or thiazolyl, each substituted with zero to 3 substituents independently selected from F, Cl, Br, —CN, —OH, —CH 3 , —CF 3 , —OCH 3 , —OCHF 2 , —OCF 3 , —C(O)OH, —C(O)OCH 3 , and cyclopropyl;

R 4b is —CH 3 , —CH 2 CH 3 , —CH 2 CH 2 CH 3 , —C(CH 3 ) 3 , —CH 2 F, —CF 3 , —CH 2 OH, —C(CH 3 ) 2 OH, —CH 2 OCH 3 , —CH 2 OCHF 2 , —CF 2 CH 2 OH, —CF 2 CH 2 OCH 3 , —CH 2 SCH 3 , cyclopropyl, —CH 2 (cyclohexyl), or —CH 2 (cyclopropyl-oxadiazolyl); and

R 4d is —OCH 3 .

6. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein:

R 4 is —CHR 4a R 4b or —CHR 4b CH 2 R 4a ;

R 4a and R 4b are independently phenyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrazolyl, imidazolyl, isoxazolyl, isothiazolyl, oxazolyl, oxadiazolyl, tetrazolyl, thiadiazolyl, thiazolyl, triazolyl, thiophenyl, tetrahydropyranyl, dihydrobenzo[b][1,4]dioxinyl, dihydrobenzo[b][1,4]dioxepinyl, dihydrobenzofuranyl, benzo[d]isoxazolyl, benzoxazinyl, benzoxazinonyl, indazolyl, indolyl, benzo[d][1,3]dioxolyl, pyrazolo[1,5-a]pyridinyl, dioxidotetrahydrothiopyranyl, quinolinyl, or naphthyridinyl, each substituted with zero to 3 substituents independently selected from F, Cl, Br, —CN, —OH, —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —C(CH 3 ) 3 , —CHF 2 , —CF 3 , —CH 2 OH, —CH 2 OCH 3 , —OCH 3 , —OCH 2 CH 3 , —OCH(CH 3 ) 2 , —OC(CH 3 ) 3 , —OCH 2 C(CH 3 ) 2 OH, —OCH 2 CH 2 OCH 3 , —OCHF 2 , —OCF 3 , —OCH 2 CH 2 N(CH 3 ) 2 , —C(O)CH 3 , —C(O)C(CH 3 ) 3 , —C(O)OH, —C(O)OCH 3 , —C(O)OC(CH 3 ) 3 , —N(CH 3 ) 2 , —P(O)(CH 3 ) 2 , —S(O) 2 CH 3 , —OCH 2 (cyclopropyl), —OCH 2 CH 2 (cyclopropyl), —OCH 2 CH 2 (morpholinyl), cyclopropyl, cyanocyclopropyl, methylazetidinyl, acetylazetidinyl, (tert-butoxycarbonyl)azetidinyl, triazolyl, tetrahydropyranyl, morpholinyl, phenyl, fluorophenyl, cyanophenyl, thiophenyl, fluorophenyl, and methylpiperidinyl.

7. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein:

R 4 is —CHR 4a R 4b :

R 4a is phenyl or pyridinyl, each substituted with zero to 2 substituents independently selected from F, Cl, Br, —CN, —CH 3 , and —OCF 3 ; and

R 4b is phenyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrazolyl, imidazolyl, isoxazolyl, isothiazolyl, oxazolyl, oxadiazolyl, tetrazolyl, thiadiazolyl, thiazolyl, triazolyl, thiophenyl, tetrahydropyranyl, dihydrobenzo[b][1,4]dioxinyl, dihydrobenzo[b][1,4]dioxepinyl, dihydrobenzofuranyl, benzo[d]isoxazolyl, benzoxazinyl, benzoxazinonyl, indazolyl, indolyl, benzo[d][1,3]dioxolyl, pyrazolo[1,5-a]pyridinyl, dioxidotetrahydrothiopyranyl, quinolinyl, or naphthyridinyl, each substituted with zero to 3 substituents independently selected from F, Cl, Br, —CN, —OH, —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —C(CH 3 ) 3 , —CHF 2 , —CF 3 , —CH 2 OH, —CH 2 OCH 3 , —OCH 3 , —OCH 2 CH 3 , —OCH(CH 3 ) 2 , —OC(CH 3 ) 3 , —OCH 2 C(CH 3 ) 2 OH, —OCH 2 CH 2 OCH 3 , —OCHF 2 , —OCF 3 , —OCH 2 CH 2 N(CH 3 ) 2 , —C(O)CH 3 , —C(O)C(CH 3 ) 3 , —C(O)OH, —C(O)OCH 3 , —C(O)OC(CH 3 ) 3 , —N(CH 3 ) 2 , —P(O)(CH 3 ) 2 , —S(O) 2 CH 3 , —OCH 2 (cyclopropyl), —OCH 2 CH 2 (cyclopropyl), —OCH 2 CH 2 (morpholinyl), cyclopropyl, cyanocyclopropyl, methylazetidinyl, acetylazetidinyl, (tert-butoxycarbonyl)azetidinyl, triazolyl, tetrahydropyranyl, morpholinyl, phenyl, fluorophenyl, cyanophenyl, thiophenyl, fluorophenyl, and methylpiperidinyl.

8. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, having the structure:

wherein:

(i) R 5a is —CN, —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —CH 2 F, —CH 2 OH, —C(O)OH, —C(O)OCH 3 , —C(O)NH 2 , cyclopropyl, —C(O)NH(cyclopropyl), or phenyl, and R 5b , R 5c , and R 5d are each H;

(ii) R 5a is cyclopropyl, R 5b is H, R 5c is cyclopropyl, and R 5d is H;

(iii) R 5b is —CN, —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —CH 2 F, —C(CH 3 ) 2 F, —CF(CH 3 )CH(CH 3 ) 2 , —CH 2 OH, —C(CH 3 ) 2 OH, —CH 2 OCH 3 , —C(O)OH, —C(O)OCH 3 , —C(O)C(CH 3 ) 2 , —C(O)OCH 3 , —C(O)OC(CH 3 ) 2 , —C(O)NH 2 , —C(CH 3 )(OH)CH(CH 3 ) 2 , —C(O)NH(cyclopropyl), —C(O)O(cyclopropyl), or methyloxadiazolyl, and R 5a , R 5c , and R 5d are each H;

(iv) R 5b is —CH 3 or methylpyridinyl, R 5c is —CH 3 , and R 5a and R 5d are each H;

(v) R 5a is —CH 3 , —CH 2 CH 3 , —CH(CH 3 ) 2 , —CH 2 OH, or —CH 2 OCH 3 , R 5c is —CH 3 , and R 5b and R 5d are each H; or

(vi) R 5a is —CH 3 , R 5b is —CH 3 or —CH 2 OCF 2 , and R 5c and R 5d are each H;

(vii) R 5a is —CH 3 , R 5c is —CH 2 CH 3 , —CH 2 CN, —CH 2 OH, —CH 2 OCH 3 , —CH 2 OCH 2 CH 3 , —CH 2 OCH 2 CH 2 OH 3 , —CH 2 N(CH 3 ) 2 , —CH 2 NHC(O)CH 3 , —CH 2 NHC(O)OCH 3 , —CH 2 NHS(O) 2 CH 3 , —CH 2 (morpholinyl), —CH 2 (hydroxyazetidinyl), or —CH 2 (methylpiperazinyl), and R 5b and R 5d are each H; or

(viii) R 5a is —CH 2 CH 3 , R 5c is —CH 2 CH 3 or —CH 2 OCH 3 , and R 5b and R 5d are each H.

9. The compound according to claim 4 or a pharmaceutically acceptable salt thereof, wherein:

R 1 is Cl, —CN, or —OCH 3 ;

R 2 is —CH 3 ; and

R 3 is H, F, Cl, or —CN.

10. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, having the structure:

wherein:

R 1 is —CN;

R 2 is —CH 3 ;

R 3 is H, F, or —CN;

R 4 is:

11. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein said compound is:

12. A pharmaceutical composition comprising an effective amount of the compound according to claim 1 or a pharmaceutically-acceptable salt thereof; and a pharmaceutically acceptable carrier.

13. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein said compound is:

8-(4-(bis(4-fluorophenyl)methyl)-3-(hydroxymethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1-2);

8-((2S,5R)-4-(bis(4-fluorophenyl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (3);

8-((2R,5S)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (4);

4-((2R,5S)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (5);

8-((2R,5S)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (6);

4-((2R,5S)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (7);

8-(4-(bis(4-fluorophenyl) methyl)-3-(fluoromethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (8);

4-(4-(bis(4-fluorophenyl)methyl)-3-(fluoromethyl)piperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (9);

(S)-8-(4-(bis(4-fluorophenyl)methyl)-3-isopropylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (10);

(S)-4-(4-(bis(4-fluorophenyl)methyl)-3-isopropylpiperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (11);

(S)-8-(4-(bis(4-fluorophenyl)methyl)-3-isopropylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (12);

(S)-4-(4-(bis(4-fluorophenyl)methyl)-3-isopropylpiperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (13);

4-(4-(bis(4-fluorophenyl)methyl)-3-(hydroxymethyl)piperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (14);

4-(4-(bis(4-fluorophenyl)methyl)-3-(hydroxymethyl)piperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (15-16);

4-(4-(bis(4-fluorophenyl)methyl)-3-(hydroxymethyl)piperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (17);

8-((2S,5R)-4-(bis(4-fluorophenyl) methyl)-2,5-dimethylpiperazin-1-yl)-7-chloro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (18);

8-((2S,5R)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-7-bromo-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (19);

8-((2S,5R)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-7-cyclopropyl-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (20);

8-((2S,5R)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-7-bromo-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (21);

8-((2S,5R)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5,7-dimethyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (22);

8-(4-(bis(4-fluorophenyl)methyl)-2-cyclopropylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (23-24);

8-((2S,5R)-4-(bis(4-chlorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (25);

8-((2S,5R)-4-(bis(4-chlorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-7-chloro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (26);

methyl 1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (27);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (28);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-7-chloro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (29);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-7-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (30);

(R)-4-(4-(bis(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (31);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (32);

(R)-8-(4-(bis(4-chlorophenyl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (33);

(R)-8-(4-(bis(4-chlorophenyl)methyl)-3-methylpiperazin-1-yl)-7-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (34);

(S)-8-(4-(bis(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (35);

(S)-8-(4-(bis(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-7-chloro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (36);

(S)-4-(4-(bis(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (37);

(S)-8-(4-(bis(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (38);

methyl 1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl) piperazine-2-carboxylate (39-40);

1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxamide (41-42);

8-(4-(bis(4-fluorophenyl)methyl)-3-cyanopiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (43);

8-(4-(bis(4-fluorophenyl)methyl)-3-cyanopiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (44-45);

1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-N-cyclopropylpiperazine-2-carboxamide (46-48);

methyl 1-(bis(4-fluorophenyl)methyl)-4-(6-bromo-3-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (49);

methyl 1-(bis(4-fluorophenyl)methyl)-4-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (50-51);

1-(bis(4-fluorophenyl)methyl)-4-(6-bromo-3-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylic acid (52);

1-(bis(4-fluorophenyl)methyl)-4-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylic acid (53-54);

1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylic acid (55);

1-(bis(4-fluorophenyl)methyl)-4-(6-bromo-3-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxamide (56);

1-(bis (4-fluorophenyl)methyl)-4-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxamide (57-58);

1-(bis(4-fluorophenyl) methyl)-4-(6-bromo-3-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-N-cyclopropylpiperazine-2-carboxamide (59);

1-(bis(4-fluorophenyl)methyl)-N-cyclopropyl-4-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl) piperazine-2-carboxamide (60-61);

isopropyl 1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (62-63);

isopropyl 1-(bis(4-fluorophenyl)methyl)-4-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (64-65);

methyl (S)-1-(bis(4-fluorophenyl) methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (66);

methyl 4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-1-((4-fluoro-2-methoxyphenyl)(4-fluorophenyl)methyl)piperazine-2-carboxylate (67-68);

methyl 4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-1-((4-fluoro-2-methoxyphenyl)(4-fluorophenyl)methyl)piperazine-2-carboxylate (69-70);

methyl 4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-1-((4-fluoro-2-methoxyphenyl)(4-fluorophenyl)methyl)piperazine-2-carboxylate (71-72);

methyl 1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-1-methyl-3-nitro-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (73);

methyl 1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-3-fluoro-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (74-75);

methyl 1-(bis(4-fluorophenyl)methyl)-4-(3-chloro-6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (76-77);

8-(4-(bis(4-fluorophenyl)methyl)-3-(2-hydroxypropan-2-yl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (78-79);

8-(4-(bis(4-fluorophenyl)methyl)-3-(2-fluoropropan-2-yl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (80-81);

8-(4-(bis(4-fluorophenyl)methyl)-3-methyl-5-(2-methylpyridin-4-yl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (84);

8-(4-(bis(4-fluorophenyl)methyl)-3-isobutyrylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (86-87);

8-(4-(bis(4-fluorophenyl)methyl)-3-(2-hydroxy-3-methylbutan-2-yl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (88-89);

8-(4-(bis(4-fluorophenyl)methyl)-3-(2-fluoro-3-methylbutan-2-yl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (90-91);

8-(4-(bis(4-fluorophenyl)methyl)-3-(methoxymethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (92-93);

methyl 1-(bis(4-chlorophenyl)methyl)-4-(6-cyano-3-fluoro-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (94-95);

methyl 1-(bis(4-chlorophenyl) methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (96-97);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-7-bromo-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (98);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-5,7-dimethyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (99);

8-(4-(bis (4-fluorophenyl)methyl)-3-(hydroxymethyl)piperazin-1-yl)-7-chloro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (100-101);

(R)-4-(4-(bis(4-chlorophenyl)methyl)-3-methylpiperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (102);

(R)-8-(4-(bis(4-chlorophenyl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (103);

(R)-8-(4-(bis(4-chlorophenyl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile, dimethylformamide (104);

(R)-8-(4-(bis(4-chlorophenyl)methyl)-3-methylpiperazin-1-yl)-7-chloro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile, dimethylformamide (105);

cyclopropyl 1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (106-107);

8-((2S,5R)-4-((4-fluoro-2-methoxyphenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (108-109);

6-bromo-4-((2S,5R)-4-((4-fluoro-2-methoxyphenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (110);

8-((2S,5R)-4-((4-fluoro-2-methoxyphenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (111-112);

methyl 4-(bis(4-fluorophenyl)methyl)-1-(6-bromo-3-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (113);

methyl 4-(bis(4-fluorophenyl)methyl)-1-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl) piperazine-2-carboxylate (114);

methyl 4-(bis(4-fluorophenyl)methyl)-1-(6-bromo-3-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (115);

methyl 4-(bis(4-fluorophenyl)methyl)-1-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (116-117);

4-(4-(bis(4-fluorophenyl)methyl)-2-(hydroxymethyl)piperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (118);

8-((2R,5S)-4-((4-fluoro-2-methoxyphenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (119);

8-((2R,5S)-4-((4-fluoro-2-methoxyphenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-7-nitro-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (120);

8-((2S,5R)-4-((4-fluoro-2-methoxyphenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-7-nitro-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (121-122);

8-(4-(bis(4-fluorophenyl) methyl)-2,3-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (123-124);

8-((2S,5S)-4-(bis(4-fluorophenyl)methyl)-2-isopropyl-5-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (125);

8-(4-(bis(4-fluorophenyl)methyl)-3-(5-methyl-1,3,4-oxadiazol-2-yl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (126);

(S)-8-(4-(bis(4-fluorophenyl)methyl)-2-ethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (127);

(S)-8-(4-(bis(4-fluorophenyl)methyl)-3-ethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (128);

8-((2S)-4-((4-fluoro-2-methoxyphenyl)(4-fluorophenyl)methyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (129-130);

8-((2R,5R)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (131);

8-((2R,5R)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-7-chloro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (132);

8-((2S,5S)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (133);

(S)-8-(4-(bis(4-fluorophenyl)methyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (134);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (135);

methyl 4-(bis(4-fluorophenyl)methyl)-1-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (136-137);

4-(bis(4-fluorophenyl) methyl)-1-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylic acid (138);

4-(bis(4-fluorophenyl)methyl)-1-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-N-cyclopropylpiperazine-2-carboxamide (139-140);

4-(bis(4-fluorophenyl)methyl)-1-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxamide (141-142);

8-(4-(bis(4-fluorophenyl)methyl)-2-cyanopiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (143-144);

8-(4-(bis(4-fluorophenyl)methyl)-2-cyanopiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (145);

8-(4-(bis(4-fluorophenyl)methyl)-2-(hydroxymethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (146-148);

8-(4-(bis(4-fluorophenyl)methyl)-2-(fluoromethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (149-151);

8-(4-(bis(4-fluorophenyl)methyl)-2,5-dicyclopropylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (152-153);

8-(4-(bis(4-fluorophenyl)methyl)-2-phenylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (154-156);

8-((2S,5R)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-7-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (157);

4-((2S,5R)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-6-bromo-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (158);

8-((2S,5R)-4-(bis(4-fluorophenyl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (159);

4-((2S,5R)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (160);

8-((2S,5R)-4-(bis(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-7-nitro-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (161);

methyl 4-(bis(4-fluorophenyl)methyl)-1-(3-bromo-6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)piperazine-2-carboxylate (162);

8-(4-(bis(4-fluorophenyl)methyl)-3,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (163);

(R)-8-(4-(bis(4-chlorophenyl)methyl)-3-isopropylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (167);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-3-isopropylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (168);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-3-isopropylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (169);

(R)-8-(4-(bis(4-fluorophenyl) methyl)-2-ethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (170);

8-(4-(bis(4-fluorophenyl)methyl)-3,3-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (171);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-3-ethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (172);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-3-ethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (173);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-3-ethylpiperazin-1-yl)-7-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (174);

(R)-8-(4-(bis(4-fluorophenyl) methyl)-3-ethylpiperazin-1-yl)-7-chloro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (175);

(R)-8-(4-(bis(4-chlorophenyl)methyl)-3-ethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (176);

(R)-8-(4-(bis(4-chlorophenyl)methyl)-3-ethylpiperazin-1-yl)-7-chloro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (177);

(R)-8-(4-(bis(4-chlorophenyl)methyl)-3-ethylpiperazin-1-yl)-7-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (178);

(R)-8-(4-(bis(4-chlorophenyl)methyl)-3-ethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (179);

(R)-8-(4-(bis(4-chlorophenyl)methyl)-3-ethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (180);

(R)-8-(4-(bis(4-fluorophenyl)methyl)-2-isopropylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (181);

8-[(2S,5R)-4-[(4-fluorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (182);

8-[(2S,5R)-4-[(4-fluorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (183-184);

8-[(2S,5R)-4-[1-(4-fluoro-2-methoxyphenyl)-2,2-dimethylpropyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (185-186);

8-[(2S,5R)-4-[(4-fluorophenyl)(3-fluoropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (187);

8-[(2S,5R)-4-[(4-fluorophenyl)(3-fluoropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (188);

8-[(2S,5R)-4-[(4-chlorophenyl)(3-fluoropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (189-190);

8-[(2S,5R)-4-[(4-chlorophenyl)(5-fluoropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (191-192);

8-[(2S,5R)-4-[(4-fluorophenyl)(5-fluoropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (193-194);

8-[(2S,5R)-4-[(4-chlorophenyl)(6-fluoropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (197-198);

8-[(2S,5R)-4-[(4-fluorophenyl)(pyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (197-198);

8-[(2S,5R)-4-[(5-chloropyridin-2-yl)(4-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (201-202);

8-[(2S,5R)-4-[(4-chlorophenyl)(5-chloropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (201-202);

8-[(2S,5R)-4-[(4-fluorophenyl)(6-methylpyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (203-204);

8-[(2S,5R)-4-[(2-ethoxypyridin-3-yl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (205-206);

8-[(2S,5R)-4-[(4-fluorophenyl)[2-(propan-2-yloxy)pyridin-3-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (207-208);

8-[(2S,5R)-4-[(4-fluorophenyl)(2-methoxypyridin-3-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (209-210);

8-[(2S,5R)-4-[(5-chloropyridin-2-yl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (211-212);

8-[(2S,5R)-4-[(4-chlorophenyl)(5-methylpyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (213-214);

8-[(2S,5R)-4-[(3-fluorophenyl)(5-methylpyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (215-216);

7-chloro-8-[(2S,5R)-4-[(4-fluorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (217-218);

3-chloro-4-{4-[(4-fluorophenyl)(phenyl) methyl]piperazin-1-yl}-6-methoxy-1-methyl-1,2-dihydro-1,5-naphthyridin-2-one (219-220);

8-[(2S,5R)-2,5-dimethyl-4-{phenyl[4-(trifluoromethoxy)phenyl]methyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (221-222);

8-[(2S,5R)-4-[(4-fluorophenyl)(3-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (223-224);

8-[(2S,5R)-4-[(4-chlorophenyl)(2-ethyl-4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (225-226);

8-[(2S,5R)-4-[(2-ethyl-4-fluorophenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (227-228);

8-[(2S,5R)-4-[(2-ethoxy-4-fluorophenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (229-230);

4-[(2S,5R)-4-[(4-chlorophenyl)(2-ethyl-4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-6-methoxy-1-methyl-1,2-dihydro-1,5-naphthyridin-2-one (231-232);

4-[(2S,5R)-4-[(2-ethyl-4-fluorophenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-6-methoxy-1-methyl-1,2-dihydro-1,5-naphthyridin-2-one (233-234);

4-[(2S,5R)-4-[(2-ethylphenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-6-methoxy-1-methyl-1,2-dihydro-1,5-naphthyridin-2-one (235-236);

8-[(2S,5R)-4-(diphenylmethyl)-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (237);

4-[(2S,5R)-4-[(4-fluorophenyl) (phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-6-methoxy-1-methyl-1,2-dihydro-1,5-naphthyridin-2-one (238-239);

4-[(2S,5R)-4-[(4-chlorophenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-6-methoxy-1-methyl-1,2-dihydro-1,5-naphthyridin-2-one (240);

4-[(2S,5R)-4-[bis(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-6-methoxy-1-methyl-1,2-dihydro-1,5-naphthyridin-2-one (241);

8-[(2S,5R)-4-{[2-(difluoromethyl)-4-fluorophenyl]methyl}-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (242);

8-[(2S,5R)-4-{[2-fluoro-4-(trifluoromethoxy)phenyl]methyl}-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (243);

8-[(2S,5R)-4-[(4-chloro-2-hydroxyphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (244);

8-[(2S,5R)-4-[(2-hydroxyphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (245);

8-[(2S,5R)-2,5-dimethyl-4-[(2,4,6-trifluorophenyl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (246);

8-[(2S,5R)-4-[(4-chlorophenyl)(4-methylphenyl) methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (247);

8-[(2S,5R)-4-[(3-fluorophenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (248);

8-[(2S,5R)-4-[(3-fluorophenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (249);

8-[(2S,5R)-4-[(4-chlorophenyl)(4-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (250);

8-[(2S,5R)-4-[(4-fluorophenyl)(4-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (251);

8-[(2S,5R)-4-[(4-fluorophenyl)(4-methylphenyl) methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (252);

8-[(2S,5R)-4-[(4-cyano-2-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (253);

8-[(2S,5R)-4-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (254);

8-[(2S,5R)-4-[(2-fluoro-6-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (255);

8-[(2S,5R)-4-[1-(2,6-difluorophenyl)ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (256);

8-[(2S,5R)-4-[bis(3-chlorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (257);

8-[(2S,5R)-4-[bis(2-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (258);

8-[(2S,5R)-4-[(2-chlorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (259);

8-[(2S,5R)-4-[(2-chloro-6-cyanophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (260);

8-[(2S,5R)-4-[(2-chloro-6-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (261);

8-[(2S,5R)-4-[(2,5-difluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (262);

8-[(2S,5R)-4-[(2,6-dichlorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (263);

8-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (264);

8-[(2S,5R)-4-[(2,6-dimethylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (265);

8-[(2S,5R)-4-[(2-chloro-3,6-difluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (266);

8-[(2S,5R)-4-[(4-cyano-2,6-difluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (267);

8-[(2S,5R)-4-[(4-chloro-2,6-difluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (268);

8-[(2S,5R)-4-[(2-cyano-6-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (269);

8-[(2S,5R)-4-[bis(3-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (270);

8-[(2S,5R)-4-[(2,6-difluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (271);

8-[(2S,5R)-4-[(2,6-difluorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (272);

8-[(2S,5R)-4-[(2,6-difluorophenyl) (phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (273);

8-[(2S,5R)-4-[(2,6-difluorophenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (274);

8-[(2S,5R)-4-[(2,6-difluorophenyl)(4-fluorophenyl) methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (275);

8-[(2S,5R)-4-[(2,3-difluorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (276);

8-[(2S,5R)-4-[(2,4-difluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (277);

8-[(2S,5R)-2,5-dimethyl-4-{[6-(trifluoromethyl)pyridin-2-yl]methyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (278);

8-[(2S,5R)-2,5-dimethyl-4-{[2-methyl-6-(trifluoromethyl)pyridin-3-yl]methyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (279);

8-[(2S,5R)-4-{[2-methoxy-6-(trifluoromethyl) pyridin-4-yl]methyl}-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (280);

8-[(2S,5R)-4-{[2-chloro-6-(trifluoromethyl)pyridin-3-yl]methyl}-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (281);

8-[(2S,5R)-4-[(3-chlorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (282);

8-[(2S,5R)-4-[(2,4-difluorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (283);

8-[(2S,5R)-4-[(2-fluorophenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (284);

8-[(2S,5R)-4-[(2-fluorophenyl)(phenyl) methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (285);

8-[(2S,5R)-4-[(2,3-difluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (286);

8-[(2S,5R)-4-[(2-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (287);

8-[(2S,5R)-4-[(3,5-difluorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (288);

8-[(2S,5R)-4-[(3,5-difluorophenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (289);

8-[(2S,5R)-4-[(3,5-difluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (290);

8-[(2S,5R)-4-[(3,4-difluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (291);

8-[(2S,5R)-4-[(3-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (292);

8-[(2S,5R)-4-[(3-fluorophenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (293);

8-[(2S,5R)-4-[(4-fluorophenyl)[4-(trifluoromethyl)phenyl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (294);

8-[(2S,5R)-4-[(4-fluorophenyl)(4-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (295);

8-[(2S,5R)-4-[(3-fluorophenyl)(phenyl) methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (296);

8-[(2S,5R)-4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (297);

8-((2S,5R)-4-((4-chlorophenyl)(4-cyanophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (298);

8-[(2S,5R)-4-[(4-chlorophenyl)(4-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (299);

8-[(2S,5R)-4-[(4-chlorophenyl)(4-fluorophenyl) methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (300);

8-[(2S,5R)-4-[bis(4-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (301);

8-((2S,5R)-4-((4-chlorophenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (302);

8-((2S,5R)-4-((4-chlorophenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (303);

8-((2S,5R)-4-((2-fluorophenyl)(4-fluorophenyl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (304);

8-((2S,5R)-4-((2-fluorophenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (305);

8-((2S,5R)-4-((4-cyanophenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (306);

8-((2S,5R)-4-((4-cyanophenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (307);

8-((2S,5R)-4-(1-(4-fluorophenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (308-309);

8-((2S,5R)-4-((4-cyanophenyl)(p-tolyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (310-311);

8-((3R)-4-((4-fluorophenyl)(pyrimidin-4-yl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (312-313);

8-((3R)-4-((4-chlorophenyl)(2-methylpyrimidin-5-yl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (314);

8-((3R)-4-((4-fluorophenyl)(2-methylpyrimidin-4-yl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (315-316);

8-((3R)-4-((4-fluorophenyl)(pyrimidin-5-yl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (317-318);

8-((3R)-4-((4-chlorophenyl) (pyrimidin-4-yl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (319-320);

8-((3R)-4-((2-(tert-butyl)pyrimidin-4-yl)(4-fluorophenyl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (321);

8-((2S,5R)-4-((4-cyanophenyl)(p-tolyl)methyl)-2,5-dimethylpiperazin-1-yl)-7-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (322);

8-((2S,5R)-4-((4-chlorophenyl)(4-(trifluoromethoxy)phenyl)methyl)-2,5-dimethylpiperazin-1-yl)-7-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (323-324);

7-fluoro-8-((2S,5R)-4-((4-fluorophenyl)(4-(trifluoromethyl) phenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (325-326);

8-((2S,5R)-4-((4-cyanophenyl)(4-fluorophenyl) methyl)-2,5-dimethylpiperazin-1-yl)-7-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (327-328);

8-((2S,5R)-4-((2,6-difluorophenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-7-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (329 and 336);

7-fluoro-8-((2S,5R)-4-((3-fluorophenyl) (4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (330-331);

7-fluoro-8-((2S,5R)-4-((4-fluorophenyl)(p-tolyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (332);

7-fluoro-8-((2S,5R)-4-((2-fluorophenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (333-334);

7-fluoro-8-((2S,5R)-4-((4-fluorophenyl)(p-tolyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (335);

8-((2S,5R)-4-(1-(2,4-difluorophenyl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (337-339);

8-[(2S,5R)-5-ethyl-2-methyl-4-[(pyridin-2-yl)[4-(trifluoromethoxy)phenyl]methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (340-341);

8-((2S,5R)-5-ethyl-2-methyl-4-(pyridin-2-yl(4-(trifluoromethoxy)phenyl)methyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (342-343);

8-((2S,5R)-4-(1-(3,4-difluorophenyl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (344);

8-((2R,5S)-2,5-dimethyl-4-(1-(4-(trifluoromethyl)phenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (345-346);

8-((2S,5R)-4-(1-(2,4-difluorophenyl) propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (347-349);

8-((2S,5R)-4-((5-ethylpyridin-2-yl)(3-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (350-351);

8-((2S,5R)-4-(2-methoxy-4-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (352);

8-((2S,5R)-4-(1-(5-chloro-2,3-dihydrobenzofuran-7-yl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (353 and 356-357);

8-((2S,5R)-4-((5-ethylpyridin-2-yl)(3-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (354);

8-((2S,5R)-4-((3-chlorophenyl)(5-ethylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (354-355);

8-((2S,5R)-4-((4-fluorophenyl)(tetrahydro-2H-pyran-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (358-359);

8-((2S,5R)-4-((4-cyanophenyl)(5-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (360-361);

8-((2S,5R)-4-((4-chlorophenyl)(4-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (362 and 364);

8-((2S,5R)-4-((4-chlorophenyl)(5-methylpyridin-2-yl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (363-365);

8-((2S,5R)-4-((3,4-difluorophenyl)(pyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (366);

8-((2S,5R)-4-((6-fluoropyridin-2-yl)(4-(trifluoromethoxy)phenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (367-368);

8-((2S,5R)-4-((3-chlorophenyl)(5-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (369);

8-((2S,5R)-4-((3-fluorophenyl)(5-(trifluoromethyl)pyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (370-371);

8-((2S,5R)-4-((3-chlorophenyl)(5-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (372);

8-((2S,5R)-4-((3-chloro-4-methylphenyl)(5-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (373 and 380);

8-((2S,5R)-4-((3-fluorophenyl)(pyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (374 and 379);

8-((2S,5R)-4-((3,4-difluorophenyl)(pyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (375-376);

8-((2S,5R)-2,5-dimethyl-4-(pyridin-2-yl(4-(trifluoromethoxy)phenyl)methyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (377-378);

8-((2S,5R)-4-((4-chlorophenyl)(pyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (381 and 382);

8-((2S,5R)-4-((4-fluorophenyl)(pyridazin-3-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (383-384);

8-((2S,5R)-4-((4-chlorophenyl)(2-methylpyrimidin-5-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (385);

8-((2S,5R)-4-((4-fluorophenyl) (5-fluoropyridin-3-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (386);

8-((2S,5R)-4-((4-fluorophenyl)(tetrahydro-2H-pyran-4-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (387-388);

8-((2S,5R)-4-((4-fluorophenyl)(2-methylpyrimidin-4-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (389);

8-((2S,5R)-4-((3-fluorophenyl)(6-methylpyridin-3-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (390);

8-((2S,5R)-4-((5-fluoropyridin-3-yl)(p-tolyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (391);

8-((2S,5R)-4-((4-fluorophenyl)(pyrimidin-4-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (392);

8-((2S,5R)-4-((4-fluorophenyl)(pyrimidin-5-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (393-394);

8-((2S,5R)-4-((3-fluorophenyl)(6-methylpyridin-3-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (395);

8-((2S,5R)-4-((4-chlorophenyl)(pyrimidin-4-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (396-397);

8-((2S,5R)-4-((3-chlorophenyl)(5-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (398);

8-((2S,5R)-4-((3-chloro-4-methylphenyl)(5-methylpyridin-2-yl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (399);

8-((2S,5R)-4-((4-fluorophenyl)(5-fluoropyridin-3-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (400);

8-((2S,5R)-4-((4-fluorophenyl)(2-methylpyrimidin-4-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (401);

8-((2S,5R)-4-((4-fluorophenyl)(pyrimidin-4-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (402);

8-((2S,5R)-4-((4-chlorophenyl)(pyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (403);

8-((2S,5R)-4-((3-fluorophenyl)(pyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (404);

8-((2S,5R)-2,5-dimethyl-4-(pyridin-2-yl(4-(trifluoromethoxy)phenyl)methyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (405);

8-((2S,5R)-4-((4-fluorophenyl)(2-methylpyrimidin-5-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (406);

8-((2S,5R)-4-(bis(5-fluoropyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (407);

8-((2S,5R)-4-((2-(tert-butyl)pyrimidin-4-yl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (408-409);

8-((2S,5R)-4-((4-fluorophenyl)(2-methylpyrimidin-5-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (410);

8-((2S,5R)-4-(1-(3,4-difluorophenyl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (411);

8-((2S,5R)-4-(1-(2-fluoro-4-(trifluoromethyl)phenyl) ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (412);

8-((3R)-4-((4-chlorophenyl)(2-methylpyrimidin-5-yl)methyl)-3-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (413-414);

8-((2S,5R)-4-((4-fluorophenyl)(5-fluoropyridin-3-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (415);

8-((2S,5R)-4-((5-fluoropyridin-3-yl)(p-tolyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (416);

8-((2S,5R)-4-((3-fluorophenyl)(6-methylpyridin-3-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (417);

8-((2S,5R)-5-ethyl-4-((4-fluorophenyl)(2-methylpyrimidin-4-yl)methyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (418-419);

8-((2S,5R)-5-ethyl-4-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)propyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (420-421);

8-((2S,5R)-4-((4-chlorophenyl) (pyridin-2-yl)methyl)-5-ethyl-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (422-423);

7-fluoro-8-((2S,5R)-4-(1-(4-fluorophenyl)ethyl-1-d)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile and 7-fluoro-8-((2S,5R)-4-(1-(4-fluorophenyl)ethyl-1-d)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (424-425);

7-fluoro-8-((2S,5R)-4-(1-(4-fluorophenyl)ethyl-1-d)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (426-427);

8-((2S,5R)-4-(1-(4-fluorophenyl)ethyl-1-d)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (428-429);

8-((2S,5R)-2,5-dimethyl-4-((2,4,6-trifluorophenyl)methyl-d2)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (430);

8-((2S,5R)-4-(1-(2-fluoro-4-(trifluoromethyl)phenyl) ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (431);

8-((2S,5R)-2,5-dimethyl-4-(1-(2,4,6-trifluorophenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (432);

8-((2S,5R)-4-(1-(2-chloro-4-fluoro-3-methylphenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (433);

8-((2S,5R)-4-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (434);

8-((2S,5R)-2,5-dim ethyl-4-(1-(4-(trifluoromethoxy)phenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (435-436);

8-((2S,5R)-4-(1-(2-fluoro-4-(trifluoromethoxy) phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (437, 439, and 442);

8-((2S,5R)-4-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (438 and 440-441);

8-((2S,5R)-4-((4-chlorophenyl)(6-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (443);

8-((2S,5R)-4-((5-fluoropyridin-2-yl)(p-tolyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (444);

8-((2S,5R)-4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)(3-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (445);

8-((2S,5R)-4-((4-chlorophenyl)(4-fluoropyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (446);

8-((2S,5R)-4-((4-chlorophenyl)(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (447);

8-((2S,5R)-4-((4-chlorophenyl)(4-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (448);

8-((2S,5R)-4-((4-fluorophenyl)(5-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (449);

8-((2S,5R)-2,5-dimethyl-4-((6-methylpyridin-2-yl)(p-tolyl)methyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (450);

8-((2S,5R)-4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)(5-methylpyridin-2-yl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (451);

8-((2S,5R)-4-((4-cyanophenyl)(5-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (452-453);

8-((2S,5R)-2,5-dimethyl-4-((5-methylpyridin-2-yl)(p-tolyl)methyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (454, 457);

8-((2S,5R)-4-((4-fluorophenyl)(4-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (455-456);

8-((2S,5R)-4-((4-chlorophenyl)(4-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (458-459);

8-((2S,5R)-2,5-dimethyl-4-((4-methylpyridin-2-yl)(p-tolyl)methyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (460-461);

8-((2S,5R)-4-((5-fluoropyridin-2-yl)(4-(trifluoromethoxy)phenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (462, 466, 468);

8-((2S,5R)-4-((4-cyanophenyl)(5-fluoropyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (463-464);

8-((2S,5R)-4-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)(5-fluoropyridin-2-yl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (465, 467);

8-((2S,5R)-4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)(5-methylpyridin-2-yl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (469);

8-((2S,5R)-4-((3-fluorophenyl)(6-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (470);

8-((2S,5R)-4-((4-fluorophenyl)(6-fluoropyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (471);

8-((2S,5R)-4-((4-fluorophenyl)(4-fluoropyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (472-474);

8-((2S,5R)-2,5-dimethyl-4-((1-methyl-1H-indazol-4-yl)methyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (475);

8-((2S,5R)-4-((6-fluoropyridin-2-yl)(p-tolyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (476, 478-479);

8-((2S,5R)-4-(cyclopropyl(2-fluoro-4-(trifluoromethoxy)phenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (480-481);

8-((2S,5R)-5-ethyl-4-(1-(4-methoxyphenyl)ethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (482-483);

8-((2S,5R)-4-((4-fluorophenyl)(4-methylpyridin-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (484);

8-((2S,5R)-2,5-dimethyl-4-((4-methylpyridin-2-yl)(p-tolyl)methyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (485);

8-((2S,5R)-4-(1-(2-chloro-4,5-difluorophenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (486);

8-((2S,5R)-4-(1-(2-chloro-4-fluoro-3-methylphenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (487);

8-((2S,5R)-2,5-dimethyl-4-(1-(2,4,6-trifluorophenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (488-489, 555);

8-[(2S,5R)-4-[2-fluoro-1-(4-fluorophenyl)ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (556);

8-((2S,5R)-4-(1-(4-fluorophenyl)-2-hydroxyethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (557-558);

8-((2S,5R)-4-(1-(4-fluorophenyl)-2-methoxyethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (559-560);

8-((2S,5R)-4-(2-(4-fluorophenyl)-2-methoxyethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (561);

8-((2S,5R)-4-(4-(1-cyanocyclopropyl)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (567);

8-((2S,5R)-4-((1-ethyl-1H-benzo[d]imidazol-7-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (568-569);

7-(difluoromethyl)-8-((2S,5R)-4-(2-fluoro-4-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (570);

8-((2S,5R)-4-(3-(dimethylamino)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (573);

8-((2S,5R)-4-(1-(4-fluorophenyl)propyl-1-d)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (574-575);

8-((2S,5R)-4-(2-cyano-4-(trifluoromethoxy) benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (581);

8-((2S,5R)-2,5-dimethyl-4-(2,2,2-trifluoro-1-(4-fluorophenyl)ethyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (582-583);

8-((2S,5R)-4-(3-cyano-4-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (584);

8-((2S,5R)-4-(4-fluoro-3-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (585);

8-((2S,5R)-2,5-dimethyl-4-(3-(trifluoromethoxy)benzyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (586);

8-((2S,5R)-4-(4-(tert-butyl)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (587);

8-((2S,5R)-4-(4-(difluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (588);

8-((2S,5R)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (589);

8-((2S,5R)-4-(4-(difluoromethoxy)-2-fluorobenzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (590);

8-((2S,5R)-4-(2-fluoro-4-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (591);

8-((2S,5R)-4-(1-(2,6-difluoro-4-hydroxyphenyl)-2,2,2-trifluoroethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (592);

8-((2S,5R)-4-(2-bromo-4-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (593);

8-((2S,5R)-4-(3-isopropoxybenzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (594);

8-((2S,5R)-4-(2-isopropoxybenzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (595);

8-((2S,5R)-4-((1-ethyl-3-fluoro-1H-indol-4-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (596);

8-((2S,5R)-4-(4-fluoro-2-isopropoxybenzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (598);

8-((2S,5R)-4-(3-ethoxybenzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (599);

8-((2S,5R)-4-(2-methoxy-5-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (601);

8-((2S,5R)-4-(4-isopropylbenzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (602);

8-((2S,5R)-4-(4-chlorobenzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (603);

8-((2S,5R)-2,5-dimethyl-4-((1-methyl-1H-indol-4-yl)methyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (606);

8-((2S,5R)-4-(2-chloro-4-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (607);

8-((2S,5R)-2,5-dimethyl-4-(2-methyl-4-(trifluoromethoxy)benzyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (608);

8-((2S,5R)-2,5-dimethyl-4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (609);

8-((2S,5R)-4-(3-fluoro-4-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (610);

8-((2S,5R)-4-(3-chloro-4-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (611);

8-((2S,5R)-2,5-dimethyl-4-((tetrahydro-2H-pyran-4-yl)methyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (623);

8-((2S,5R)-4-(2-fluoro-4-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (624);

8-((2S,5R)-2,5-dimethyl-4-(2,2,2-trifluoro-1-(2-fluoro-4-hydroxyphenyl)ethyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (625);

8-((2S,5R)-2,5-dim ethyl-4-(2,2,2-trifluoro-1-(4-hydroxyphenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (626);

8-((2S,5R)-4-(1-(2,6-difluoro-4-hydroxyphenyl)-2,2,2-trifluoroethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (627-628);

8-((2S,5R)-4-(3-bromo-4-(trifluoromethoxy)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (629);

tert-butyl 8-{[(2R,5S)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-2,5-dimethylpiperazin-1-yl]methyl}-3,4-dihydro-2H-1,4-benzoxazine-4-carboxylate (630);

8-[(2S,5R)-4-[(4-acetyl-3,4-dihydro-2H-1,4-benzoxazin-8-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (631);

8-[(2S,5R)-2,5-dimethyl-4-(2-phenylethyl)piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (632);

8-[(2S,5R)-2,5-dimethyl-4-[2-(4-methylphenyl)ethyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (633);

8-[(2S,5R)-4-[(3,4-dihydro-2H-1,4-benzoxazin-8-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (634);

8-[(2S,5R)-2,5-dimethyl-4-[(4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-5-yl) methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (635);

8-[(2S,5R)-2,5-dimethyl-4-{1-[6-(trifluoromethyl)pyridin-2-yl]ethyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (636-637);

8-[(2S,5R)-2,5-dimethyl-4-[1-(quinolin-5-yl)ethyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (638-639);

8-[(2S,5R)-4-[1-(5-fluoropyridin-2-yl)ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (640-641);

8-[(2S,5R)-2,5-dimethyl-4-{1-[5-(trifluoromethyl)pyridin-2-yl]ethyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (642-643);

8-[(2S,5R)-4-[1-(5-methoxypyridin-2-yl)ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (644-645);

8-[(2S,5R)-4-[1-(4-cyclopropyl-1,3-thiazol-2-yl)ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (646-647);

8-[(2S,5R)-2,5-dimethyl-4-[1-(5-methyl-1,2-oxazol-3-yl)ethyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (648-649);

8-[(2S,5R)-2,5-dimethyl-4-[1-(quinoxalin-6-yl) ethyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (650-651);

8-[(2S,5R)-4-{1-[4-(difluoromethoxy)phenyl]ethyl}-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (652-653);

8-[(2S,5R)-4-[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (654-655);

8-[(2S,5R)-4-[(4-chlorophenyl)(2,2-difluoro-2H-1,3-benzodioxol-5-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (656-657);

8-[(2S,5R)-4-[(4-fluorophenyl)(4-methoxyphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (658-659);

8-[(2S,5R)-4-[(4-fluorophenyl)(3-methoxyphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (660-661);

8-[(2S,5R)-4-[(4-fluorophenyl) [4-(morpholin-4-yl)phenyl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (662-663);

8-[(2S,5R)-4-[(4-fluorophenyl)[2-(morpholin-4-yl)phenyl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (664-665);

8-[(2S,5R)-4-{[4-(difluoromethyl) phenyl](4-fluorophenyl)methyl}-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (666-667);

8-[(2S,5R)-4-[(2,2-difluoro-2H-1,3-benzodioxol-4-yl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (668-669);

8-[(2S,5R)-4-[(4-chlorophenyl) (phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (670-671);

8-[(2S,5R)-4-[(4-fluorophenyl)[3-(morpholin-4-yl)phenyl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (672-673);

8-[(2S,5R)-4-[(4-fluorophenyl)(pyrazin-2-yl) methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (674-675);

8-[(2S,5R)-4-[(4-fluorophenyl)(pyrimidin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (676-677);

8-[(2S,5R)-4-[(4-fluorophenyl)[6-(trifluoromethyl)pyridin-2-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (678-679);

8-[(2S,5R)-4-[(4-fluorophenyl)[5-(trifluoromethyl)pyridin-2-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (680-681);

8-[(2S,5R)-4-[(2,4-difluorophenyl)(pyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (682-683);

8-[(2S,5R)-4-[(2,4-difluorophenyl)(5-fluoropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (684-685);

8-[(2S,5R)-4-[(3-fluorophenyl)(5-methoxypyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (686-687);

8-[(2S,5R)-4-[(4-fluorophenyl)(3-methanesulfonylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (688-689);

8-[(2S,5R)-4-[(3-fluorophenyl)[5-(propan-2-yloxy)pyridin-2-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (690-691);

8-[(2S,5R)-4-[(4-fluorophenyl)(2,4,6-trifluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (692-693);

8-[(2S,5R)-4-[(4-fluorophenyl)({pyrazolo[1,5-a]pyridin-7-yl})methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (694-695);

8-[(2S,5R)-4-{[6-(difluoromethyl)pyridin-2-yl](4-fluorophenyl)methyl}-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (696-697);

8-[(2S,5R)-4-[(4-fluorophenyl)({pyrazolo[1,5-a]pyridin-3-yl})methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (698-699);

8-((2S,5R)-4-((4-cyclopropylthiazol-2-yl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (700-701);

8-[(2S,5R)-4-[(4-fluorophenyl)(1-methyl-1H-pyrazol-4-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (702-703);

8-[(2S,5R)-4-[(4-fluorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (704-705);

8-[(2S,5R)-4-[(4-fluorophenyl)(1,2-oxazol-3-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (706-707);

8-[(2S,5R)-4-[(4-fluorophenyl)(1-methyl-1H-imidazol-4-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (708);

8-[(2S,5R)-4-[(4-fluorophenyl)(1,3-oxazol-4-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (709-710);

8-[(2S,5R)-4-[(4-fluorophenyl)(1,3-thiazol-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (711-712);

8-[(2S,5R)-4-[(4-fluorophenyl)(1-methyl-1H-imidazol-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (713-714);

8-[(2S,5R)-4-[(4-fluorophenyl)(1,2-thiazol-4-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (715-716);

8-[(2S,5R)-4-[(4-fluorophenyl)(1,3-oxazol-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (717-718);

8-[(2S,5R)-4-[(4-fluorophenyl)(1,2-thiazol-5-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (719-720);

8-[(2S,5R)-4-[(4-fluorophenyl)(1,3-thiazol-4-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (721-722);

8-[(2S,5R)-4-[(2-cyclopropyl-1,3-thiazol-4-yl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (723-724);

8-[(2S,5R)-4-[(1-cyclopropyl-1H-pyrazol-4-yl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (725-726);

8-[(2S,5R)-4-[(2-cyclopropyl-1,3-thiazol-5-yl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (727-728);

8-((2S,5R)-4-((5-cyclopropylisoxazol-3-yl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (729-730);

8-((2S,5R)-4-((5-(tert-butyl)isoxazol-3-yl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (731-732);

8-((2S,5R)-4-((4-fluorophenyl)(5-methylisoxazol-3-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (733-734);

8-((2S,5R)-4-((3-cyclopropyl-1,2,4-oxadiazol-5-yl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (735-736);

8-[(2S,5R)-4-[(3-tert-butyl-1,2,4-oxadiazol-5-yl)(4-fluorophenyl) methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (737-738);

8-[(2S,5R)-4-[(4-fluorophenyl)[3-(oxan-4-yl)-1,2,4-oxadiazol-5-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (739-740);

8-[(2S,5R)-4-[(4-fluorophenyl)[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (741-742);

8-[(2S,5R)-4-{[3-(difluoromethyl)-1,2,4-oxadiazol-5-yl](4-fluorophenyl)methyl}-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (743-744);

8-[(2S,5R)-4-[(4-fluorophenyl) (3-methyl-1,2,4-oxadiazol-5-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (745-746);

8-[(2S,5R)-4-[(4-fluorophenyl)[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (747-748);

8-[(2S,5R)-4-[(4-fluorophenyl) [3-(morpholin-4-yl)-1,2,4-oxadiazol-5-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (749-750);

8-[(2S,5R)-4-[(4-fluorophenyl)[3-(1-methylpiperidin-4-yl)-1,2,4-oxadiazol-5-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (751-752);

8-[(2S,5R)-4-[(3-ethyl-1,2,4-oxadiazol-5-yl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (753-754);

8-[(2S,5R)-4-[(4-fluorophenyl)(1,2,4-oxadiazol-5-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (755);

tert-butyl 3-(5-{[(2R,5S)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-2,5-dimethylpiperazin-1-yl](4-fluorophenyl)methyl}-1,2,4-oxadiazol-3-yl)azetidine-1-carboxylate (756-757);

8-[(2S,5R)-4-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)[4-(trifluoromethoxy)phenyl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (758-759);

8-[(2S,5R)-4-[(4-bromophenyl)(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (760-761);

8-((2S,5R)-4-((5-cyclopropyl-1,3,4-oxadiazol-2-yl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (762-763);

8-((2S, R)-4-((5-(tert-butyl)-1,2,4-oxadiazol-3-yl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (764-765);

8-((2S,5R)-4-((5-cyclopropyl-4H-1,2,4-triazol-3-yl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (766-767);

8-((2S,5R)-4-((3-cyclopropyl-1-methyl-1H-1,2,4-triazol-5-yl)(4-fluorophenyl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (768-769);

8-((2S,5R)-4-((1-(tert-butyl)-1H-tetrazol-5-yl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (770-771);

8-((2S,5R)-4-((4-fluorophenyl)(5-isopropyl-1,3,4-thiadiazol-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (772-773);

8-((2S,5R)-4-((5-cyclopropyl-1,3,4-thiadiazol-2-yl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (774-775);

8-((2S,5R)-4-((4-cyclopropyloxazol-2-yl)(4-fluorophenyl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (776-777);

8-[(2S,5R)-4-[(4-tert-butyl-1,3-oxazol-2-yl)(4-fluorophenyl) methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (778-779);

8-((2S,5R)-4-(1-(2,6-difluorophenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (780-781);

8-[(2S,5R)-4-[1-(4-fluorophenyl)ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (782-783);

8-[(2S,5R)-2,5-dimethyl-4-[1-(4-methylphenyl)ethyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (784-785);

4-{1-[(2R,5S)-4-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-2,5-dimethylpiperazin-1-yl]ethyl}benzoic acid (786-787);

8-[(2S,5R)-2,5-dimethyl-4-{1-[4-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (788);

8-[(2S,5R)-4-[1-(4-bromophenyl)ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (789-790);

8-[(2S,5R)-4-[1-(4-chlorophenyl)ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (791-792);

methyl 4-{1-[(2R,5S)-4-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-2,5-dimethylpiperazin-1-yl]ethyl}benzoate (793-794);

methyl 3-{1-[(2R,5S)-4-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-2,5-dimethylpiperazin-1-yl]ethyl}benzoate (795-796);

8-[(2S,5R)-4-[1-(2-fluorophenyl) ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (797-798);

8-[(2S,5R)-4-[1-(5-methoxypyridin-2-yl)ethyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (799-800);

8-[(2S,5R)-2,5-dimethyl-4-{1-[4-(trifluoromethoxy)phenyl]ethyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (801-802);

8-[(2S,5R)-2,5-dimethyl-4-[1-(5-methyl-1,2-oxazol-3-yl)ethyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (803-804);

8-[(2S,5R)-4-[bis(4-chlorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (805);

8-[(2S,5R)-4-[bis(4-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (806);

8-[(2S,5R)-4-[(4-fluorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (807-808);

8-[(2S,5R)-4-[(2-ethylphenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (809-810);

8-[(2S,5R)-4-[(4-ethylphenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (811-812);

8-[(2S,5R)-4-[(3,5-difluorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (813-814);

8-[(2S,5R)-4-[(4-fluorophenyl) (6-methylpyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (815-816);

8-[(2S,5R)-4-[(4-fluorophenyl)(4-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (817-818);

8-[(2S,5R)-4-[(4-chlorophenyl)(3-fluoropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (819 and 822);

8-[(2S,5R)-4-[(4-fluorophenyl)(3-fluoropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (820-821);

8-[(2S,5R)-4-[(4-cyanophenyl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (823-824);

8-[(2S,5R)-4-[(4-chlorophenyl)(4-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (825-826);

8-[(2S,5R)-4-[(4-fluorophenyl)(5-fluoropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (827-828);

8-[(2S,5R)-4-[(4-chlorophenyl)(5-fluoropyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (829-830);

8-[(2S,5R)-4-[(2-chloro-4-fluorophenyl)(5-methylpyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (831-832);

8-[(2S,5R)-4-[(5-fluoropyridin-2-yl)(4-methylphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (833);

8-[(2S,5R)-4-[(4-chlorophenyl)(phenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (834-835);

8-[(2S,5R)-4-[(4-fluorophenyl)[5-(trifluoromethyl)pyridin-2-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (836-837);

8-[(2S,5R)-4-[(4-fluorophenyl)(4-methoxyphenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (838-839);

8-[(2S,5R)-4-[(3-fluorophenyl)[5-(trifluoromethyl)pyridin-2-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (840-841);

8-[(2S,5R)-4-[(4-fluorophenyl)(pyridin-2-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (842-843);

8-[(2S,5R)-4-[(4-fluorophenyl)[6-(trifluoromethyl)pyridin-2-yl]methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (844-845);

8-[(2S,5R)-4-[(4-fluorophenyl)(1-methyl-1H-pyrazol-4-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (846-847);

8-[(2S,5R)-4-[(4-fluorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (848-849);

8-[(2S,5R)-4-[(4-fluorophenyl)(1,2-oxazol-3-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (850-851);

8-[(2S,5R)-4-[(4-fluorophenyl)(1-methyl-1H-imidazol-4-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (852-853);

8-[(2S,5R)-4-[(4-fluorophenyl)(1,2-thiazol-5-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (854-855);

8-[(2S,5R)-4-[(4-fluorophenyl)(1,3-thiazol-4-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (856-857);

8-[(2S,5R)-4-[(2-cyclopropyl-1,3-thiazol-4-yl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (858-859);

8-[(2S,5R)-4-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (860-861);

8-[(2S,5R)-4-[(3-tert-butyl-1,2,4-oxadiazol-5-yl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (862-863);

8-[(2S,5R)-4-[(4-fluorophenyl)(5-methyl-1,2-oxazol-3-yl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (864-865);

8-[(2S,5R)-4-[(5-tert-butyl-1,2-oxazol-3-yl) (4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (866-867);

8-[(2S,5R)-4-[(5-cyclopropyl-1,2-oxazol-3-yl)(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (868-869);

8-[(3R)-4-[bis(4-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (870);

8-[(3R)-4-[(4-cyanophenyl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (871);

8-[(3R)-4-[(4-chlorophenyl)(4-cyanophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (872-873);

8-[(3R)-4-[(3,5-difluorophenyl) (phenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (874-875);

8-[(3R)-4-[(2-ethylphenyl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (876-877);

8-[(3R)-4-[(4-fluorophenyl)(phenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (878-879);

8-[(3R)-4-[(3-fluorophenyl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (880-881);

8-[(3R)-4-[(2-fluorophenyl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (882-883);

8-[(3R)-4-[(4-ethylphenyl)(4-fluorophenyl) methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (884-885);

8-[(3R)-4-[(4-chlorophenyl)(phenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (886-887);

8-[(3R)-4-[(4-fluorophenyl)(4-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (888-889);

8-[(3R)-4-[(3-fluoropyridin-2-yl)(4-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (890 and 892);

8-[(3R)-4-[(4-fluorophenyl)(3-fluoropyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (891 and 893);

8-[(3R)-4-[(4-fluorophenyl) (2-methoxypyridin-3-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (894-895);

8-[(3R)-4-[(4-fluorophenyl)[5-(trifluoromethyl)pyridin-2-yl]methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (896-897);

8-[(3R)-4-[(5-fluoropyridin-2-yl) (4-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (898-899);

8-[(3R)-4-[(4-chlorophenyl)(5-fluoropyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (900-901);

8-[(3R)-4-[(4-fluorophenyl)(5-fluoropyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (902-903);

8-[(3R)-4-[(4-fluorophenyl)(5-methylpyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (904);

8-[(3R)-4-[(4-fluorophenyl)(6-methylpyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (905-906);

8-[(3R)-4-[(4-chlorophenyl)(4-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (907);

8-[(3R)-4-[(5-cyanopyridin-2-yl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (908);

8-[(3R)-4-[(4-chlorophenyl)(3-fluoropyridin-2-yl) methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (909);

8-[(3R)-4-[(4-fluorophenyl)[4-(trifluoromethyl)phenyl]methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (910);

8-[(3R)-4-[(3-fluorophenyl)(5-fluoropyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (911);

8-[(3R)-4-[(3-fluorophenyl)(5-methylpyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (912);

8-[(3R)-4-[(4-chlorophenyl) (3-fluoropyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (913);

8-[(3R)-4-[(4-fluorophenyl)[4-(trifluoromethyl) phenyl]methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (914);

8-[(3R)-4-[(4-fluorophenyl)(5-methylpyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (915);

8-[(3R)-4-[(4-fluorophenyl)(3-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (916-917);

8-[(3R)-4-[(4-fluorophenyl)(pyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (918-919);

8-[(3R)-4-[(4-cyanophenyl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (920);

8-[(3R)-4-[(4-fluorophenyl)[6-(trifluoromethyl) pyridin-2-yl]methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (921-922);

8-[(3R)-4-[(3-fluorophenyl)(5-methylpyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (923);

8-[(3R)-4-[(5-cyanopyridin-2-yl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (924);

8-[(3R)-4-[(3-fluorophenyl)(5-fluoropyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (925);

8-[(3R)-4-[(3-chlorophenyl)(5-fluoropyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (926-927);

8-[(3R)-4-[(3-chlorophenyl) (5-methylpyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (928-929);

8-[(3R)-4-[(4-chlorophenyl)(5-chloropyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (930-931);

8-[(3R)-4-[(5-chloropyridin-2-yl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (932-933);

8-[(3R)-4-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (934-935);

8-[(3R)-4-[(5-chloropyridin-2-yl)(4-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (936-937);

8-[(3R)-4-[(2-chloro-4-fluorophenyl)(5-methylpyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (938);

8-[(3R)-4-[(2,2-difluoro-2H-1,3-benzodioxol-4-yl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (939-940);

8-[(3R)-4-[(4-chlorophenyl)(2,2-difluoro-2H-1,3-benzodioxol-5-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (941-942);

8-[(3R)-4-[(4-fluorophenyl)(pyrazin-2-yl) methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (943);

8-[(3R)-4-[(4-chlorophenyl)(4-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (944-945);

8-[(3R)-4-[(2,4-difluorophenyl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (946-947);

8-[(3R)-4-[(3-fluorophenyl)[5-(trifluoromethyl)pyridin-2-yl]methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (948-949);

8-[(3R)-4-[1-(2,6-difluorophenyl)ethyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (950-951);

5-methyl-8-[(3R)-3-methyl-4-[1-(4-methylphenyl)ethyl]piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (952-953);

8-[(3R)-4-[1-(4-cyanophenyl)ethyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (954-955);

8-[(3R)-4-[1-(3,4-difluorophenyl)ethyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (956);

8-[(3R)-4-[1-(4-fluorophenyl)ethyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (957 and 959);

5-methyl-8-[(3R)-3-methyl-4-{1-[4-(trifluoromethoxy)phenyl]ethyl}piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (958 and 962);

5-methyl-8-[(3R)-3-methyl-4-{1-[4-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (960-961);

5-methyl-8-[(3R)-3-methyl-4-[1-(pyridin-2-yl)ethyl]piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (963 and 965);

5-methyl-8-[(3R)-3-methyl-4-[1-(6-methylpyridin-2-yl) ethyl]piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (964);

5-methyl-8-[(3R)-3-methyl-4-{1-[2-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (966 and 968);

5-methyl-8-[(3R)-3-methyl-4-[1-(6-methylpyridin-2-yl)ethyl]piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (967);

8-[(3R)-4-[1-(2,4-difluorophenyl)ethyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (969-970);

5-methyl-8-[(3R)-3-methyl-4-{1-[3-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (971-972);

4-{1-[(2R)-4-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-2-methylpiperazin-1-yl]ethyl}benzoic acid (973-974);

8-[(3R)-4-[1-(4-bromophenyl)ethyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (974-975);

8-[(3R)-4-[1-(2,5-dimethylphenyl)ethyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (976-977);

8-[(3R)-4-[1-(4-chlorophenyl) ethyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (978-979);

methyl 4-{1-[(2R)-4-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-2-methylpiperazin-1-yl]ethyl}benzoate (980-981);

methyl 3-{1-[(2R)-4-(3,6-dicyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-2-methylpiperazin-1-yl]ethyl}benzoate (982-983);

8-[(3R)-4-[(2-chloro-6-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (984);

8-[(3R)-4-[(2,4-difluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (985);

5-methyl-8-[(3R)-3-methyl-4-[(2,4,6-trifluorophenyl)methyl]piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (986);

8-[(3R)-4-[(3,4-difluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (987);

5-methyl-8-[(3R)-3-methyl-4-[(6-methylpyridin-2-yl)methyl]piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (988);

8-[(3R)-4-[(6-cyanopyridin-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (989);

5-methyl-8-[(3R)-3-methyl-4-[(pyridin-2-yl)methyl]piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (990);

5-methyl-8-[(3R)-3-methyl-4-{[6-(trifluoromethyl)pyridin-2-yl]methyl}piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (991);

5-methyl-8-[(3R)-3-methyl-4-[(quinolin-2-yl)methyl]piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (992);

8-[(3R)-4-[(2-chloro-4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (993);

8-[(3R)-4-({[1,1′-biphenyl]-4-yl}methyl)-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (994);

8-[(3R)-4-[(4-fluoro-3-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (995);

8-[(3R)-4-[(3,4-dichlorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (996);

8-[(3R)-4-[(2-chlorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (997);

5-methyl-8-[(3R)-3-methyl-4-[(pyridin-3-yl)methyl]piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (998);

5-methyl-8-[(3R)-3-methyl-4-{[2-(trifluoromethoxy)phenyl]methyl}piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (999);

8-[(3R)-4-[(3,5-dimethylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1000);

8-[(3R)-4-[(5-fluoro-2-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1001);

8-[(3R)-4-[(3-fluoro-4-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1002);

5-methyl-8-[(3R)-3-methyl-4-{[3-(trifluoromethyl)phenyl]methyl}piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1003);

8-[(3R)-4-({[1,1′-biphenyl]-3-yl}methyl)-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1004);

8-[(3R)-4-[(3-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1005);

8-[(3R)-4-[(2-fluoro-5-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1006);

5-methyl-8-[(3R)-3-methyl-4-[(4-methylphenyl) methyl]piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1007);

5-methyl-8-[(3R)-3-methyl-4-{[3-(trifluoromethoxy)phenyl]methyl}piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1008);

8-[(3R)-4-[(2-cyanophenyl) methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1009);

8-[(3R)-4-[(3-fluoro-2-methylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1010);

8-[(3R)-4-[(4-chlorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1011);

5-methyl-8-[(3R)-3-methyl-4-[(3-methylphenyl) methyl]piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1012);

8-[(3R)-4-[(4-tert-butylphenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1013);

5-methyl-8-[(3R)-3-methyl-4-{[2-(trifluoromethyl)phenyl]methyl}piperazin-1-yl]-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1014);

8-[(3R)-4-[(4-chloro-3-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1015);

8-[(3R)-4-[(4-fluorophenyl)(1-methyl-1H-pyrazol-4-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1016-1017);

8-[(3R)-4-[(4-fluorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1018-1019);

8-[(3R)-4-[(4-fluorophenyl)(1,3-oxazol-4-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1022-1023);

8-[(3R)-4-[(4-fluorophenyl)(1,3-thiazol-2-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1024-1025);

8-[(3R)-4-[(4-fluorophenyl)(1-methyl-1H-imidazol-4-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1026-1027);

8-[(3R)-4-[(4-fluorophenyl)(1,2-thiazol-4-yl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1028);

8-[(3R)-4-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1029-1030);

8-[(2S,5R)-4-[(4-chlorophenyl)(4-fluorophenyl)methyl]-2,5-diethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1031);

8-[(2S,5R)-4-[bis(4-chlorophenyl) methyl]-2,5-diethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1032);

8-[(2S,5R)-4-[(4-chlorophenyl)(5-fluoropyridin-2-yl)methyl]-2,5-diethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1033-1034);

8-[(2S,5R)-4-[(4-cyanophenyl)(4-fluorophenyl)methyl]-2,5-diethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1035-1036);

8-[(2S,5R)-2,5-diethyl-4-[(4-fluorophenyl)(3-fluoropyridin-2-yl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1037-1038);

8-[(2S,5R)-2,5-diethyl-4-[(4-fluorophenyl)[5-(trifluoromethyl)pyridin-2-yl]methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1039-1040);

8-[(2S,5R)-2,5-diethyl-4-[(3-fluorophenyl)(5-fluoropyridin-2-yl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1041-1042);

8-[(2S,5R)-2,5-diethyl-4-[(4-fluorophenyl)(pyridin-2-yl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1043-1044);

8-[(2S,5R)-2,5-diethyl-4-[(4-fluorophenyl)[6-(trifluoromethyl)pyridin-2-yl]methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1045-1046);

8-[(2S,5R)-2,5-diethyl-4-[(3-fluorophenyl)(5-methoxypyridin-2-yl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1047-1048);

8-[(2S,5R)-2,5-diethyl-4-[1-(4-fluorophenyl)ethyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1049-1050);

8-[(2S,5R)-2,5-diethyl-4-{1-[4-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1051-1052);

8-[(2S,5R)-2,5-diethyl-4-{1-[4-(trifluoromethoxy)phenyl]ethyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1053-1054);

8-[(2S,5R)-4-[1-(2,4-difluorophenyl)ethyl]-2,5-diethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1055-1056);

8-[(2S,5R)-2,5-diethyl-4-{1-[2-fluoro-4-(trifluoromethoxy)phenyl]propyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1057-1058);

8-[(2S,5R)-2,5-diethyl-4-{1-[4-(trifluoromethoxy)phenyl]propyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1059-1060);

8-[(2S,5R)-2,5-diethyl-4-[(4-fluorophenyl) methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1061);

8-[(2S,5R)-4-[(2,4-difluorophenyl)methyl]-2,5-diethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1062);

8-[(2S,5R)-4-[(2,2-difluoro-2H-1,3-benzodioxol-5-yl)methyl]-2,5-diethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1063);

8-[(2S,5R)-4-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)(4-fluorophenyl)methyl]-2,5-diethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1064-1065);

8-[(2S,5R)-4-[(4-cyclopropyl-1,3-thiazol-2-yl)(4-fluorophenyl)methyl]-2,5-diethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1066-1067);

8-[(2S,5R)-2,5-diethyl-4-[(4-fluorophenyl)(1,3-oxazol-4-yl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1068-1069);

8-[(2S,5R)-2,5-diethyl-4-[(4-fluorophenyl) (1,3-thiazol-4-yl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1070-1071);

8-[(2S,5R)-2,5-diethyl-4-[(4-fluorophenyl)(1,2-oxazol-3-yl) methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1072-1073);

8-[(2S,5R)-4-[(5-cyclopropyl-1,2-oxazol-3-yl)(4-fluorophenyl)methyl]-2,5-diethylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1074-1075);

8-[(2S,5R)-4-benzyl-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1076);

8-[(2S,5R)-4-[(2,4-difluorophenyl) methyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1077);

8-[(2S,5R)-4-[(2-chloro-4-fluorophenyl)methyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1078);

8-[(2S,5R)-5-ethyl-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1079);

8-[(2S,5R)-5-ethyl-2-methyl-4-[(2,4,6-trifluorophenyl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1080);

8-[(2S,5R)-5-ethyl-4-{[2-methoxy-4-(trifluoromethoxy)phenyl]methyl}-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1081);

8-[(2S,5R)-4-[(2,2-difluoro-2H-1,3-benzodioxol-5-yl)methyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1082);

8-[(2S,5R)-5-ethyl-4-[1-(4-fluorophenyl)ethyl]-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1083-1084);

8-[(2S,5R)-5-ethyl-4-{1-[2-fluoro-4-(trifluoromethyl)phenyl]ethyl}-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1085-1086);

8-[(2S,5R)-4-[1-(2,4-difluorophenyl)ethyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1087-1088);

8-[(2S,5R)-5-ethyl-2-methyl-4-[1-(2,4,6-trifluorophenyl)ethyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1089-1090);

8-[(2S,5R)-4-[1-(3,4-difluorophenyl)ethyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1091-1092);

8-[(2S,5R)-5-ethyl-2-methyl-4-{1-[4-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1093-1094);

8-[(2S,5R)-5-ethyl-4-{1-[2-fluoro-4-(trifluoromethoxy)phenyl]ethyl}-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1095-1096);

8-[(2S,5R)-4-[bis(4-fluorophenyl)methyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1097);

8-[(2S,5R)-4-[bis(4-methylphenyl)methyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1098);

8-[(2S,5R)-4-[bis(4-chlorophenyl)methyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1099);

8-[(2S,5R)-4-[(4-chlorophenyl)(4-fluorophenyl)methyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1100-1101);

8-[(2S,5R)-4-[(4-cyanophenyl)(4-fluorophenyl)methyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1102-1103);

8-[(2S,5R)-5-ethyl-4-[(4-fluorophenyl)(3-fluoropyridin-2-yl)methyl]-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1104-1105);

8-[(2S,5R)-5-ethyl-4-[(4-fluorophenyl)[5-(trifluoromethyl)pyridin-2-yl]methyl]-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1106-1107);

8-[(2S,5R)-5-ethyl-4-[(3-fluorophenyl)(5-fluoropyridin-2-yl)methyl]-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1108-1109);

8-[(2S,5R)-4-[(4-chlorophenyl)(5-fluoropyridin-2-yl)methyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1110-1111);

8-[(2S,5R)-5-ethyl-4-[(4-fluorophenyl)[6-(trifluoromethyl)pyridin-2-yl]methyl]-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1112-1113);

8-[(2S,5R)-5-ethyl-4-[(4-fluorophenyl)(1,2-oxazol-3-yl)methyl]-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1114-1115);

8-[(2S,5R)-4-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)(4-fluorophenyl)methyl]-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1116-1117);

8-[(2S,5R)-4-[bis(4-fluorophenyl)methyl]-2-ethyl-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1118);

8-[(2S,5R)-4-[bis(4-methylphenyl)methyl]-2-ethyl-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1119);

8-[(2S,5R)-4-[bis(4-chlorophenyl)methyl]-2-ethyl-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1120);

8-[(2S,5R)-4-[(4-chlorophenyl)(4-methylphenyl)methyl]-2-ethyl-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1121-1122);

8-[(2S,5R)-4-[(4-cyanophenyl)(4-fluorophenyl)methyl]-2-ethyl-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1123-1124);

8-[(2S,5R)-2-ethyl-4-[(3-fluorophenyl)(5-methylpyridin-2-yl)methyl]-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1125-1126);

8-[(2S,5R)-4-[(4-chlorophenyl)(4-fluorophenyl)methyl]-2-ethyl-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1127-1128);

8-[(2S,5R)-4-[(4-chlorophenyl)(5-fluoropyridin-2-yl)methyl]-2-ethyl-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1129-1130);

8-[(2S,5R)-2-ethyl-4-[(4-fluorophenyl)[5-(trifluoromethyl)pyridin-2-yl]methyl]-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1131-1132);

8-[(2S,5R)-2-ethyl-4-[(4-fluorophenyl)[6-(trifluoromethyl)pyridin-2-yl]methyl]-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1133-1134);

8-[(2S,5R)-2-ethyl-4-[1-(4-fluorophenyl)ethyl]-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1135-1136);

8-[(2S,5R)-4-[1-(2,4-difluorophenyl) ethyl]-2-ethyl-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1137-1138);

8-[(2S,5R)-4-[1-(3,4-difluorophenyl)ethyl]-2-ethyl-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1139-1140);

8-[(2S,5R)-2-ethyl-5-methyl-4-{1-[4-(trifluoromethoxy)phenyl]ethyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1141-1142);

8-[(2S,5R)-2-ethyl-5-methyl-4-{1-[4-(trifluoromethyl)phenyl]ethyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1143-1144);

8-[(2S,5R)-4-{1-[4-(difluoromethoxy)phenyl]ethyl}-2-ethyl-5-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1145);

8-[(2S,5R)-2-ethyl-5-methyl-4-{1-[4-(trifluoromethoxy)phenyl]propyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1146-1147);

8-[(2S,5R)-2-ethyl-5-methyl-4-[(2,4,6-trifluorophenyl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1148);

8-[(2S,5R)-2-ethyl-5-methyl-4-[(3,4,5-trifluorophenyl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1149);

8-(4-(bis(4-fluorophenyl)methyl)-3-(hydroxymethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1150);

8-[(2S,5S)-4-[bis(4-fluorophenyl)methyl]-5-(hydroxymethyl)-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1151);

8-[(2S,5S)-4-[bis(4-chlorophenyl)methyl]-5-(hydroxymethyl)-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1152);

8-[(2S,5S)-4-[(3-fluorophenyl)(5-methylpyridin-2-yl)methyl]-5-(hydroxymethyl)-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1153-1154);

8-((2S,5S)-4-(bis(4-fluorophenyl)methyl)-5-(methoxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1155);

8-[(2S,5S)-4-[bis(4-methylphenyl) methyl]-5-(methoxymethyl)-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1156);

8-((2S,5S)-4-((4-cyanophenyl)(4-fluorophenyl) methyl)-5-(methoxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1157-1158);

8-((2S,5S)-4-(1-(4-fluorophenyl)ethyl)-5-(methoxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1159-1160);

8-[(2S,5S)-5-(methoxymethyl)-2-methyl-4-[(3,4,5-trifluorophenyl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1161);

8-[(2S,5S)-5-(methoxymethyl)-2-methyl-4-{1-[4-(trifluoromethoxy)phenyl]ethyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1162-1163);

8-((2S,5S)-4-(bis(4-fluorophenyl)methyl)-5-(ethoxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1164);

N-(((2R,5S)-1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-5-methylpiperazin-2-yl)methyl)acetamide (1165);

methyl (((2R,5S)-1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-5-methylpiperazin-2-yl)methyl)carbamate (1166);

8-((2S,5R)-4-(bis(4-fluorophenyl)methyl)-2-methyl-5-(morpholinomethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1167);

8-[(2S,5R)-4-[bis(4-fluorophenyl)methyl]-5-[(3-hydroxyazetidin-1-yl)methyl]-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1168);

8-[(2S,5R)-4-[bis(4-fluorophenyl)methyl]-5-[(dimethylamino)methyl]-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1169);

8-((2S,5S)-4-((4-cyanophenyl)(4-fluorophenyl)methyl)-2-ethyl-5-(methoxymethyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1170-1171);

8-((2R,5R)-4-(bis(4-fluorophenyl)methyl)-5-(hydroxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1172);

8-[(2R,5R)-4-[bis(4-methylphenyl)methyl]-5-(hydroxymethyl)-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1173);

8-[(2R,5R)-4-[(4-chlorophenyl)(4-fluorophenyl)methyl]-5-(hydroxymethyl)-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1174-1175);

8-[(2R,5R)-4-[(4-cyanophenyl)(4-fluorophenyl)methyl]-5-(hydroxymethyl)-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1176-1177);

8-[(2R,5R)-4-[1-(4-fluorophenyl) ethyl]-5-(hydroxymethyl)-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1178-1179);

8-[(2R,5R)-5-(hydroxymethyl)-2-methyl-4-{1-[4-(trifluoromethoxy)phenyl]ethyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1180-1181);

8-[(2R,5R)-5-(hydroxymethyl)-2-methyl-4-[(2,4,6-trifluorophenyl)methyl]piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1182);

8-((2R,5R)-4-(bis(4-fluorophenyl)methyl)-5-(methoxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1183);

8-(4-(2-chloro-4-fluorobenzyl)-3-((difluoromethoxy) methyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1184-1185);

8-{4-[bis(4-fluorophenyl)methyl]-3-[(difluoromethoxy)methyl]piperazin-1-yl}-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1186-1187);

8-((2S,5R)-4-(2-(difluoromethoxy)-1-(4-fluorophenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1188-1189);

8-[(2S,5R)-4-{cyclopropyl[4-(trifluoromethoxy)phenyl]methyl}-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1190);

4-[(2S,5R)-2,5-dimethyl-4-{1-[4-(trifluoromethoxy)phenyl]ethyl}piperazin-1-yl]-1,6-dimethyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile (1191-1192);

8-[(2S,5R)-5-ethyl-2-methyl-4-(1-phenylbutyl)piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1193-1194);

8-[(2S,5R)-4-{2-cyclohexyl-1-[4-(trifluoromethoxy)phenyl]ethyl}-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1195-1196);

8-[(2S,5R)-4-{[2,4-bis(trifluoromethyl)phenyl]methyl}-5-ethyl-2-methylpiperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1197);

8-[(2S,5R)-5-ethyl-2-methyl-4-{1-[4-(trifluoromethoxy)phenyl]propyl}piperazin-1-yl]-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1198-1199);

8-((2S,5R)-4-(1-(4-cyclopropyl-2-fluorophenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1200-1201);

8-((2S,5R)-4-(1-(2-fluoro-5-(trifluoromethoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1202-1203);

8-((2S,5R)-4-(1-(3-fluoro-4-(trifluoromethoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1204-1205);

8-((2S,5R)-4-(1-(2-fluoro-5-(trifluoromethoxy)phenyl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1206-1207);

8-((2S,5R)-4-(1-(2-fluoro-3-(trifluoromethoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1208-1209);

8-((2S,5R)-4-(1-(3-fluoro-5-(trifluoromethoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1210-1211);

8-((2S,5R)-2,5-dim ethyl-4-(1-(2-(trifluoromethoxy)phenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1212-1213);

8-((2S,5R)-4-(1-(4-cyclopropylphenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1214-1215);

8-((2S,5R)-4-(1-(2,2-difluorobenzo[d][1,3]dioxol-4-yl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1216-1217);

8-((2S,5R)-4-(1-(4-cyclopropyl-2-fluorophenyl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1218-1219);

8-((2S,5R)-4-(1-(4-cyclopropylphenyl) propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1220-1221);

8-((2S,5R)-4-(1-(6-(difluoromethyl)pyridin-2-yl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1222-1223);

8-((2S,5R)-4-(1-(5-(difluoromethoxy)pyridin-2-yl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1224-1225);

8-((2S,5R)-4-(1-(4-cyano-2-fluorophenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1226-1227);

8-((2S,5R)-4-(1-(5-(difluoromethoxy)-2-fluorophenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1228-1229);

8-((2S,5R)-4-(1-(4-chloro-2-fluorophenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1230);

8-((2S,5R)-4-(1-(4-fluoro-3-methoxyphenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1231-1232);

8-((2S,5R)-4-(1-(4-isopropylphenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1233-1234);

8-((2S,5R)-2,5-dim ethyl-4-(3,4,5-trifluorobenzyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1235);

8-((2S,5R)-4-(1-(4-fluoro-2-methoxyphenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1236-1237);

8-((2S,5R)-4-(1-(4-(1H-1,2,4-triazol-1-yl) phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1238-1239);

8-((2S,5R)-2,5-dimethyl-4-(1-(3,4,5-trifluorophenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1240-1241);

8-((2S,5R)-4-(1-(2,6-difluoro-4-methoxyphenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1242-1243);

8-((2S,5R)-4-(1-(2,5-difluoro-4-methoxyphenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1244-1245);

8-((2S,5R)-4-(1-(2-fluoro-4,5-dimethoxyphenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1246-1247);

8-((2S,5R)-4-(1-(4-methoxy-3-(trifluoromethyl)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1248-1249);

8-((2S,5R)-4-(1-(4-(1-cyanocyclopropyl)-2-fluorophenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1250-1251);

8-((2S,5R)-4-(1-(4-(1-cyanocyclopropyl)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1253-1254);

8-((2S,5R)-4-(1-(4-fluoro-3-methylphenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1255);

8-((2S,5R)-4-(1-(3-chloro-4-fluorophenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1256-1257);

8-((2S,5R)-4-(1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1258-1259);

8-((2S,5R)-2,5-dimethyl-4-(1-(2-methylbenzo[d]oxazol-4-yl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1260-1261);

8-((2S,5R)-4-(1-(3-cyano-4-fluorophenyl) ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1262);

8-((2S,5R)-2,5-dimethyl-4-(1-(2-methylbenzo[d]thiazol-6-yl)ethyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1263-1264);

8-((2S,5R)-4-(1-(4-(methoxymethyl)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1265-1266);

8-((2S,5R)-2,5-dim ethyl-4-(1-(3-(trifluoromethoxy)phenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1267-1268);

8-((2S,5R)-4-(1-(3-fluoro-4-(trifluoromethoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1269-1270);

8-((2S,5R)-4-(1-(3-(difluoromethoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1271-1272);

8-((2S,5R)-2,5-dim ethyl-4-(1-(2-(trifluoromethyl)thiazol-4-yl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1273-1274);

8-((2S,5R)-4-(4-ethoxy-2,6-difluorobenzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1275-1276);

8-((2S,5R)-4-(2-methoxy-1-(5-(trifluoromethyl)pyridin-2-yl) ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1277-1278);

8-((2S,5R)-4-(2-hydroxy-1-(5-(trifluoromethyl)pyridin-2-yl) ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1279-1280);

8-((2S,5R)-4-(1-(5-cyclopropylisoxazol-3-yl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1281-1282);

8-((2S,5R)-4-(1-(5-(tert-butyl)isoxazol-3-yl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1283-1284);

8-((2S,5R)-4-((4-chlorophenyl)(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1285-1286);

8-((2S,5R)-4-((2-(dimethylphosphoryl)phenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1287-1288);

8-((2S,5R)-4-(4-(dimethylphosphoryl)benzyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1289);

8-((2S,5R)-4-(1-(4-(dimethylphosphoryl)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1290-1291);

8-((2S,5R)-4-((4-(dimethylphosphoryl)phenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1292-1293);

8-((2S,5R)-4-(1-(4-(dimethylphosphoryl)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1294-1295);

8-((2S,5R)-4-((3-(1-acetylazetidin-3-yl)-1,2,4-oxadiazol-5-yl)(4-fluorophenyl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1296-1297);

8-((2S,5R)-4-((4-fluorophenyl)(3-(1-methylazetidin-3-yl)-1,2,4-oxadiazol-5-yl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1298-1299);

8-((2S,5R)-4-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1300-1301);

8-((2S,5R)-4-(1-(4-methoxy-3-(2-methoxyethoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1302-1303);

8-((2S,5R)-4-(1-(4-methoxy-3-(2-morpholinoethoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1304-1305);

8-((2S,5R)-4-(1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1306-1307);

8-((2S,5R)-4-(1-(4-fluorophenyl)-2-hydroxy-2-methylpropyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1308-1309);

8-((2S,5R)-4-(2,2-difluoro-1-(4-fluorophenyl)-3-hydroxypropyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1310-1311);

8-((2S,5R)-4-(2,2-difluoro-1-(4-fluorophenyl)-3-methoxypropyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1312-1313);

8-((2S,5R)-4-(1-(4-fluoro-2-(methoxymethyl) phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1314-1315);

8-((2S,5R)-4-(1-(4-fluoro-3-(methoxymethyl) phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1316-1317);

8-((2S,5R)-4-(1-(4-fluorophenyl)-2-(methylthio)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1318-1319);

8-((2S,5R)-4-(1-(4-cyano-3-(2-methoxyethoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1320-1321);

8-((2S,5R)-4-(1-(4-cyano-3-(2-(dimethylamino)ethoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1322-1323);

8-((2S,5R)-4-(1-(6-isopropoxypyridin-3-yl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1324-1325);

8-((2S,5R)-4-(2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1-(4-fluorophenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1326-1327);

8-((2S,5R)-5-ethyl-2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)ethyl)piperazin-1-yl)-7-fluoro-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1328-1329);

8-((2S,5R)-4-(4-(difluoromethoxy)benzyl)-5-ethyl-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1330);

8-((2S,5R)-4-(4-chloro-2-fluorobenzyl)-5-ethyl-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1331);

8-((2S,5R)-5-ethyl-4-(3-fluoro-4-(trifluoromethoxy)benzyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1332);

8-((2S,5R)-4-((4-fluorophenyl)(2-(trifluoromethyl)thiazol-4-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1333-1334);

8-((2S,5R)-4-(bis(4-(hydroxymethyl)phenyl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1335);

8-((2S,5R)-4-((4-cyanophenyl)(4-fluorophenyl)methyl)-2,5-dimethylpiperazin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1336-1337);

8-((2S,5R)-4-((4-cyclopropylthiazol-2-yl)(4-fluorophenyl) methyl)-5-ethyl-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1338-1339);

8-((2S,5R)-4-(1-(4-cyclopropyl-2-fluorophenyl)ethyl)-5-ethyl-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1340-1341);

8-((2S,5R)-4-(4-(difluoromethoxy)benzyl)-5-ethyl-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1342);

8-((2S,5R)-4-(1-(4-(difluoromethoxy)phenyl)ethyl)-5-ethyl-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1343-1344);

8-((2S,5R)-4-(1-(4-cyanophenyl)ethyl)-5-ethyl-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1345-1346);

8-((2S,5R)-5-ethyl-4-(2-fluoro-4-(trifluoromethoxy)benzyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1347);

8-((2S,5R)-5-ethyl-4-(1-(4-isopropoxyphenyl)ethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1348-1349);

8-((2S,5R)-5-ethyl-4-(1-(4-methoxyphenyl) ethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1350-1351);

8-((2S,5R)-4-(1-(4-chloro-2-fluorophenyl)ethyl)-5-ethyl-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1352-1353);

8-((2S,5R)-2,5-diethyl-4-(3,4,5-trifluorobenzyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1354);

8-((2S,5R)-4-(1-(4-cyclopropylphenyl)ethyl)-2,5-diethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1355-1356);

8-((2S,5R)-4-(1-(4-cyclopropyl-2-fluorophenyl)ethyl)-2,5-diethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1357-1358);

8-((2S,5R)-4-(1-(4-cyclopropyl-2-fluorophenyl)propyl)-2,5-diethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1359-1360);

8-((2S,5R)-2,5-diethyl-4-((4-fluorophenyl)(2-(trifluoromethyl)thiazol-4-yl)methyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1361-1362);

8-((2S,5R)-2,5-diethyl-4-(4-(trifluoromethoxy) benzyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1363);

8-((2S,5R)-2,5-diethyl-4-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1364-1365);

8-((2S,5R)-2,5-diethyl-4-(1-(4-methoxyphenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1366-1367);

8-((2S,5R)-4-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)ethyl)-2,5-diethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1368-1369);

8-((2S,5R)-2,5-diethyl-4-(2-fluoro-4-(trifluoromethoxy)benzyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1370);

8-((2S,5R)-2,5-diethyl-4-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1371-1372);

8-((2S,5R)-4-(1-(4-(difluoromethoxy)phenyl) ethyl)-2,5-diethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1373-1374);

8-((2S,5R)-4-(1-(4-(difluoromethoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile (1375-1376);

8-((2S,5R)-2-ethyl-4-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)propyl)-5-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1377-1378);

8-((2S,5R)-4-(1-(4-(difluoromethoxy)phenyl)ethyl)-2-ethyl-5-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1379);

8-((2S,5R)-2-ethyl-4-(1-(2-fluoro-5-(trifluoromethoxy)phenyl)propyl)-5-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1380-1381);

8-((2S,5R)-2-ethyl-5-methyl-4-(1-(3,4,5-trifluorophenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1382-1383);

8-((2S,5R)-2-ethyl-4-(1-(3-fluoro-5-(trifluoromethoxy)phenyl)ethyl)-5-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1384-1385);

8-((2S,5S)-5-(hydroxymethyl)-2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)ethyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1386-1387);

8-((2S,5S)-4-((4-fluorophenyl)(5-(trifluoromethyl)pyridin-2-yl)methyl)-5-(hydroxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1388-1389);

8-((2S,5S)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)-5-(hydroxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1390);

8-((2S,5S)-4-((4-fluorophenyl)(isoxazol-3-yl)methyl)-5-(hydroxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1391-1392);

8-((2S,5S)-4-((3-cyclopropyl-1,2,4-oxadiazol-5-yl)(4-fluorophenyl)methyl)-5-(methoxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1393-1394);

8-((2S,5S)-4-((4-cyclopropylthiazol-2-yl)(4-fluorophenyl)methyl)-5-(methoxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1395-1396);

8-((2S,5S)-5-(ethoxymethyl)-2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)ethyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1397-1398);

8-((2S,5S)-4-((4-fluorophenyl)(isoxazol-3-yl) methyl)-5-(methoxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1399-1400);

8-((2S,5S)-4-((4-fluorophenyl)(5-(trifluoromethyl)pyridin-2-yl)methyl)-5-(methoxymethyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1401-1402);

8-((2S,5S)-5-(ethoxymethyl)-4-((4-fluorophenyl)(5-(trifluoromethyl)pyridin-2-yl) methyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1403-1404);

8-((2S,5S)-5-((2-methoxyethoxy)methyl)-2-methyl-4-(1-(4-(trifluoromethoxy) phenyl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1405-1406);

8-((2S,5S)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)-2-ethyl-5-(methoxymethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1407);

8-((2S,5S)-2-ethyl-5-(methoxymethyl)-4-(1-(4-(trifluoromethoxy)phenyl)ethyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1408-1409);

N-(((2S,5S)-1-(bis(4-fluorophenyl)methyl)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-5-methylpiperazin-2-yl)methyl)methanesulfonamide (1410);

8-((2S,5R)-5-(cyanomethyl)-2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)ethyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1411-1412);

8-((2S,5R)-5-((dimethylamino) methyl)-2-methyl-4-(1-(4-(trifluoromethoxy)phenyl) ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1413-1414);

5-methyl-8-((2S,5R)-2-methyl-5-(morpholinomethyl)-4-(1-(4-(trifluoromethoxy) phenyl)ethyl)piperazin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1415-1416);

5-methyl-8-((2S,5R)-2-methyl-5-((4-methylpiperazin-1-yl)methyl)-4-(1-(4-(trifluoromethoxy)phenyl)ethyl) piperazin-1-yl)-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1417-1418);

8-((2R,5R)-2-(hydroxymethyl)-5-methyl-4-(1-(4-(trifluoromethoxy)phenyl)ethyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1419-1420);

8-((2R,5R)-4-(bis(4-fluorophenyl)methyl)-2-(methoxymethyl)-5-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1421);

8-((2S,5R)-4-((4-cyanothiophen-2-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1422);

8-((2S,5R)-4-((1-cyclopropyl-1H-tetrazol-5-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1423);

8-((2S,5R)-2,5-dimethyl-4-((5-methylisoxazol-3-yl) methyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1424);

8-((2S,5R)-2,5-dimethyl-4-((3-phenylisoxazol-5-yl)methyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1425);

8-((2S,5R)-4-((3,5-dimethylisoxazol-4-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1426);

8-((2S,5R)-4-((3-(2-cyanophenyl)isoxazol-5-yl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1427);

8-((2S,5R)-4-(isoxazol-4-ylmethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1428);

8-((2S,5R)-4-((2-(3-fluorophenyl)-5-methyloxazol-4-yl)methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1429-1430);

8-((2S,5R)-2,5-dimethyl-4-((5-methylisoxazol-4-yl)methyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1431);

8-((2S,5R)-4-((5-isopropyl-1,2,4-oxadiazol-3-yl) methyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1432);

8-((2S,5R)-4-(benzo[d]isoxazol-3-ylmethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1433);

8-((2S,5R)-2,5-dimethyl-4-((2-(thiophen-2-yl)oxazol-4-yl)methyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1434);

8-((2S,5R)-2,5-dimethyl-4-((1-methyl-1H-1,2,3-triazol-4-yl)methyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1435);

8-((2S,5R)-2,5-dimethyl-4-((5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)methyl) piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1436);

8-((2S,5R)-2,5-dimethyl-4-(1-(5-methyl-1,3,4-oxadiazol-2-yl)ethyl)piperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1437-1438);

8-((2S,5R)-4-(1-(4-(cyclopropylmethoxy)phenyl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1439-1440);

8-((2S,5R)-4-(1-(4-(tert-butoxy)phenyl)ethyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1441-1442);

8-((2S,5R)-4-(1-(4-(tert-butoxy)phenyl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1443-1444);

8-((2S,5R)-4-(1-(4-(2-cyclopropylethoxy)phenyl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1445-1446);

8-((2S,5R)-5-ethyl-4-(1-(4-isopropoxyphenyl)propyl)-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1447-1448);

8-((2S,5R)-4-(1-(4-isopropoxyphenyl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1449-1450);

8-((2S,5R)-4-(1-(4-(cyclopropylmethoxy)phenyl)propyl)-5-ethyl-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1451);

8-((2S,5R)-4-(1-(4-(2-hydroxy-2-methylpropoxy)phenyl)propyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1452);

8-((2S,5R)-4-(1-(4-(2-cyclopropylethoxy)phenyl)propyl)-5-ethyl-2-methylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1453); or

8-((2S,5R)-4-(1-(4-fluorophenyl)cyclopropyl)-2,5-dimethylpiperazin-1-yl)-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile (1454).

Assignments (3)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 27, 2019

From: VELAPARTHI, UPENDER; CHUPAK, LOUIS S.; DARNE, CHETAN PADMAKAR; DING, MIN; GENTLES, ROBERT G.; HUANG, YAZHONG; MARTIN, SCOTT W.; MCDONALD, IVAR M.; OLSON, RICHARD E.; ZHENG, XIAOFAN; TOKARSKI, JOHN S.; DASGUPTA, BIRESHWAR

To: BRISTOL-MYERS SQUIBB COMPANY

Reel/Frame 050512/0416 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 27, 2019

From: SYNGENE INTERNATIONAL LIMITED

To: BRISTOL-MYERS SQUIBB COMPANY

Reel/Frame 050512/0816 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 27, 2019

From: KAMBLE, MANJUNATHA NARAYANA RAO; MANNOORI, RAJU; RAHAMAN, HASIBUR; JALAGAM, PRASADA RAO; ROY, SAUMYA; TONUKUNURU, GOPIKISHAN; VELAIAH, SIVASUDAR; WARRIER, JAYAKUMAR SANKARA; REDDY, KOTHA RATHNAKAR; RAJA, THIRUVENKADAM

To: SYNGENE INTERNATIONAL LIMITED

Reel/Frame 050516/0596 →

Continuity (3)

Provisional Application 62690439 · Jun 27, 2018

Provisional Application 62840459 · Apr 30, 2019

Related Publication 20200109140A1 · Apr 9, 2020

Cited By (2)

US 12,454,531 US 12,492,172