Sample processing improvements for microscopy
Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.
1. An apparatus comprising
a movable body comprising a body surface, and
a base comprising a sample surface to receive a microscopy sample between the sample surface and the body surface, the body being configured to pivot about a pivot axis,
the body surface comprising a bounding perimeter having a pivot edge,
the pivot edge comprising a pivot portion and a non-pivot portion adjacent the pivot portion, the non-pivot portion forming at least part of a path for flow of the microscopy sample away from the sample surface towards the pivot axis when the body pivots about the pivot axis.
2. The apparatus of claim 1 which the pivot extended portion comprises two or more pivot sub-portions.
3. The apparatus of claim 2 in which the two or more pivot sub-portions comprise collinear edges.
4. The apparatus of claim 1 in which the non-pivot portion is recessed away from the pivot axis relative to the pivot portion.
5. The apparatus of claim 1 in which locations of contact between a bearing segment and the pivot edge define the pivot axis.
6. The apparatus of claim 1 in which the body surface is rectangular.
7. The apparatus of claim 1 comprising a barrier configured to restrict movement of the movable body and maintain alignment between the movable body and the sample surface.
8. The apparatus of claim 1 comprising a mechanism configured to move the movable body toward the sample surface.
9. The apparatus of claim 8 in which the mechanism comprises a point of contact that bears the movable body, and
in which the mechanism exerts a force pushing the movable body against a portion of the base.
10. The apparatus of claim 1 in which the sample surface comprises a surface of an imaging sensor.
11. A method comprising
pivoting a body about a pivot axis toward a sample surface bearing a microscopy sample, the body comprising a body surface,
the pivoting of the body comprising
causing a pivot portion of a pivot edge of the body surface to bear against a feature associated with the sample surface, with the microscopy sample between the sample surface and the body surface, and
causing, by movement of the body surface, a portion of the microscopy sample to flow away from the sample surface towards the pivot axis through a path formed at least in part by a non-pivot portion of the pivot edge.
12. The method of claim 11 in which pivoting the body comprises positioning the body surface at an angle to the sample surface and in contact with at least a portion of the microscopy sample.
13. The method of claim 12 in which pivoting the body comprises repositioning the body surface to be parallel to the sample surface and in contact with the microscopy sample.
14. The method of claim 11 in which the pivoting comprises automatically moving.
15. The method of claim 11 in which the pivoting comprises moving at a controlled velocity.
16. The method of claim 11 in which pivoting the body comprises allowing the body surface to settle on the microscopy sample.
17. The method of claim 11 in which pivoting the body comprises resting the body on a support without fixing the body to the support.