Calcium alginate dosage formulations, and methods of making and using thereof
An alginate and stearic acid composition is described, including methods of molding it into tablets further comprising a drug, and methods of controlling the drug release from the tablets.
1. A drug dosage tablet comprising a core; a first coating disposed over the core; and a second coating disposed over the first coating;
wherein the core comprises an alginate, a drug, a fatty acid, and a cellulose;
wherein the first coating comprises an oil and a cellulose;
wherein the first coating is 80-90% oil by weight; and
wherein the second coating comprises calcium alginate.
2. The drug dosage tablet of claim 1 , wherein the alginate is sodium alginate.
3. The drug dosage tablet of claim 1 , wherein the fatty acid comprises stearic acid, sodium stearate, or a combination thereof.
4. The drug dosage tablet of claim 1 , wherein the core further comprises a sugar.
5. The drug dosage tablet of claim 1 , wherein the cellulose comprises ethyl cellulose or microcrystalline cellulose.
6. The drug dosage tablet of claim 1 , wherein the tablet has a spherical shape.
7. A method of delivering a drug to a subject, the method comprising administering to the subject the drug dosage tablet of claim 1 .
8. A method of delivering a drug to a subject in need thereof, the method comprising:
providing the drug dosage tablet of claim 1 , wherein the tablet further comprises an electrode;
delivering the drug dosage tablet to the colon of the subject;
applying an electric current to the drug dosage tablet; and
releasing the drug from the drug dosage tablet.
9. The method of claim 8 , wherein the electrode is a cathode.
10. The method of claim 8 , wherein the drug release follows zero order kinetics.
11. The method of claim 8 , wherein less than 20% of the drug is released over 24 hours in the absence of the electric current.
12. A method of making a tamper-resistant drug delivery system, comprising:
providing a formulation comprising a fatty acid, a cellulose, a drug, and an alginate;
pressing the formulation into a solid tablet;
disposing a first coating comprising an oil and a cellulose over the solid tablet, wherein the first coating is 80-90% oil by weight;
disposing a second coating comprising alginic acid or sodium alginate over the first coating; and
disposing calcium chloride over the second coating.
13. The method of claim 12 , wherein the step of disposing calcium chloride over the second coating comprises the step of:
spraying the second coating with a calcium chloride solution.
14. The method of claim 12 , wherein the tablet is pressed with a Carver press.
15. The method of claim 12 , wherein the formulation further comprises lactose.