Collagen sol for submucosal local injection
Object of the present invention is to provide a safe sol for submucosal local injection which gels and creates a mucosal elevation having a high retention rate of mucosal elevation height when locally injected into a digestive submucosa. Provided is a sol for submucosal local injection containing from 0.2 mass % to 1.2 mass % of a collagen, water, a buffer, and from 200 mM to 420 mM sodium chloride.
1. A method of treating a submucosa, which comprises injecting a sol comprising from 0.2 mass % to 1.2 mass % of a collagen, water, a buffer, and from 220 mM to 310 mM sodium chloride into the submucosa, wherein denaturation temperature of the collagen is 37° C. or more and 50° C. or less.
2. The method according to claim 1 , wherein the sol further comprises from 40 mg/L to 1400 mg/L of genipin or a genipin derivative.
3. The method according to claim 1 , wherein the sol has a pH from 6.0 to 9.0 and the buffer contains a phosphate.
4. The method according to claim 1 , wherein the sol comprises from 40 mg/L to 1400 mg/L of genipin or a genipin derivative.
5. An endoscope system for endoscopic mucosal resection or endoscopic submucosal dissection, comprising a unit for locally injecting a sol comprising from 0.2 mass % to 1.2 mass % of a collagen, water, a buffer, and from 220 mM to 310 mM sodium chloride, wherein denaturation temperature of the collagen is 37° C. or more and 50° C. or less.
6. The method according to claim 3 , wherein the sol comprises from 40 mg/L to 1400 mg/L of genipin or a genipin derivative.
7. The method according to claim 1 , wherein the sol forms a gel when injected.
8. The method according to claim 1 , wherein the sol results in a mucosal elevation when locally injected into the submucosa.
9. The system according to claim 5 , wherein the sol further comprises from 40 mg/L to 1400 mg/L of genipin or a genipin derivative.
10. The system according to claim 5 , wherein the sol has a pH from 6.0 to 9.0 and the buffer contains a phosphate.
11. The system according to claim 5 , wherein the sol forms a gel when injected.
12. The system according to claim 5 , wherein the sol results in a mucosal elevation when locally injected into the submucosa.