Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2

1. A compound having structural Formula I-c′:

or a pharmaceutically acceptable salt thereof wherein:

R 1 is

R 2 is

R 3 is

R 4 is

(1) hydrogen, or

(2) (C 1-3 )alkyl,

or R 3 and R 4 combine along with the nitrogen atom to which they are attached to form a 4- to 7-membered mono- or 6- to 10-membered bicyclic heterocyclyl ring, containing 1 or 2 heteroatoms independently selected from N, O and S, wherein the heterocyclyl ring is unsubstituted or substituted by 1-3 R 6 ; and

R 6 is

(1) (C 1-3 )alkyl,

(2) halo(C 1-3 )alkyl-,

(3) oxo,

(4) (C 3-6 )cycloalkyl,

(5) —C(O)O—(C 1-4 )alkyl,

(6) NH 2 ,

(7) hydroxy,

(8) phenyl unsubstituted or substituted by halo,

(9) hydroxy(C 1-3 )alkyl-,

(10) cyano,

(11) halo, or

(12) —S(O) 2 —(C 1-3 )alkyl.

2. The compound of claim 1 wherein R 3 and R 4 combine along with the nitrogen atom to which they are attached to form

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein R 2 is

or a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 , wherein R 3 is

or a pharmaceutically acceptable salt thereof.

5. A compound of claim 1 , selected from the group consisting of

(1) 3-(2-Chlorophenyl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(2) 3-(2-Chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(3) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-{1-[1-oxido-6-(trifluoromethyl)pyridin-3-yl]ethyl}-1H-indazole-6-carboxamide,

(4) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-{1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}-1H-indazole-6-carboxamide,

(5) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-{(1S)-2-hydroxy-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-1H-indazole-6-carboxamide,

(6) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(1-methyl-2-oxopyrrolidin-3-yl)-1H-indazole-6-carboxamide,

(7) tert-butyl 4-[1-({[3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazol-6-yl]carbonyl}amino)ethyl]-1H-imidazole-1-carboxylate,

(8) N-[(3R,4R)-4-amino-1,1-dioxidotetrahydrothiophen-3-yl]-3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(9) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[4-hydroxy-1,1-dioxidotetrahydrothiophen-3-yl]-1H-indazole-6-carboxamide,

(10) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[6-(trifluoromethyl)pyridin-3-yl]-1H-indazole-6-carboxamide,

(11) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-{(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-1H-indazole-6-carboxamide,

(12) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1S)-2-methoxy-1-methylethyl]-1H-indazole-6-carboxamide,

(13) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-{(1S)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-1H-indazole-6-carboxamide,

(14) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[1-(1H-imidazol-4-yl)ethyl]-1H-indazole-6-carboxamide,

(15) N-tert-butyl-3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(16) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[1-methyl-1-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-indazole-6-carboxamide,

(17) 3-(2-chlorophenyl)-N-[1-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl]-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(18) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}-1H-indazole-6-carboxamide,

(19) tert-butyl N-{[3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazol-6-yl]carbonyl}-beta-alaninate,

(20) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(2-sulfamoylethyl)-1H-indazole-6-carboxamide,

(21) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-oxetan-3-yl-1H-indazole-6-carboxamide,

(22) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(1-methyl-5-oxopyrrolidin-3-yl)-1H-indazole-6-carboxamide,

(23) 3-(2-chlorophenyl)-6-[(3,3-dioxido-3-thia-6-azabicyclo[3.2.1]oct-6-yl)carbonyl]-1-(4-fluorophenyl)-1H-indazole,

(24) 3-(2-chlorophenyl)-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(25) 3-(2-chlorophenyl)-N-[2-(dimethylsulfamoyl)ethyl]-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(26) 3-(2-chlorophenyl)-N-[2-(ethylsulfonyl)ethyl]-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(27) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-methyl-N-[1-(5-phenyl-1H-pyrazol-3-yl)ethyl]-1H-indazole-6-carboxamide,

(28) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-{1-methyl-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-1H-indazole-6-carboxamide,

(29) 3-(2-chlorophenyl)-N-[(1,1-dioxidotetrahydrothiophen-3-yl)methyl]-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(30) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-{(1R)-2-hydroxy-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-1H-indazole-6-carboxamide,

(31) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(pyridin-3-ylmethyl)-1H-indazole-6-carboxamide,

(32) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(pyridin-2-ylmethyl)-1H-indazole-6-carboxamide,

(33) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(pyridin-4-ylmethyl)-1H-indazole-6-carboxamide,

(34) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1S)-1-(2-methylpyrimidin-5-yl)ethyl]-1H-indazole-6-carboxamide,

(35) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(imidazo[1,2-a]pyrimidin-2-ylmethyl)-1H-indazole-6-carboxamide,

(36) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[1-(4-methyl-4H-1,2,4-triazol-3-yl)ethyl]-1H-indazole-6-carboxamide,

(37) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(isoxazol-4-ylmethyl)-1H-indazole-6-carboxamide,

(38) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(pyrimidin-5-ylmethyl)-1H-indazole-6-carboxamide,

(39) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-(4H-1,2,4-triazol-4-yl)ethyl]-1H-indazole-6-carboxamide,

(40) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(1,2,5-thiadiazol-3-ylmethyl)-1H-indazole-6-carboxamide,

(41) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[1-(5-methyl-1,2,4-oxadiazol-3-yl)ethyl]-1H-indazole-6-carboxamide,

(42) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(2-hydroxy-1,1-dimethylethyl)-1H-indazole-6-carboxamide,

(43) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[1-(hydroxymethyl)cyclopentyl]-1H-indazole-6-carboxamide,

(44) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1-hydroxycyclohexyl)methyl]-1H-indazole-6-carboxamide,

(45) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(2-methoxyethyl)-1H-indazole-6-carboxamide,

(46) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]-1H-indazole-6-carboxamide,

(47) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]-1H-indazole-6-carboxamide,

(48) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1R,2S)-2-hydroxy-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]-1H-indazole-6-carboxamide,

(49) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-{[2-(trifluoromethyl)pyrimidin-5-yl]methyl}-1H-indazole-6-carboxamide,

(50) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}-1H-indazole-6-carboxamide,

(51) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1R)-1-methyl-2-sulfamoylethyl]-1H-indazole-6-carboxamide,

(52) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(2-oxopyrrolidin-3-yl)-1H-indazole-6-carboxamide,

(53) 3-(2-chlorophenyl)-N-[2-(cyclohexylsulfamoyl)ethyl]-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(54) N-[2-(benzylsulfamoyl)ethyl]-3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(55) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-(pyridin-2-ylsulfamoyl)ethyl]-1H-indazole-6-carboxamide,

(56) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-(phenylsulfamoyl)ethyl]-1H-indazole-6-carboxamide,

(57) 3-(2-chlorophenyl)-N-(2,5-dioxopyrrolidin-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(58) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(1-oxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(59) methyl 3-({[3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazol-6-yl]carbonyl}) amino)tetra-hydrothiophene-3-carboxylate,

(60) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-(pyridin-3-ylsulfamoyl)ethyl]-1H-indazole-6-carboxamide,

(61) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[1-(hydroxymethyl)cyclopropyl]-1H-indazole-6-carboxamide,

(62) ethyl 1-({[3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazol-6-yl]carbonyl}amino)cyclopropanecarboxylate,

(63) methyl 1-({[3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazol-6-yl]carbonyl}amino)cyclopentanecarboxylate,

(64) 3-(2-chlorophenyl)-N-(3,3-difluorocyclopentyl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(65) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[1-(hydroxymethyl)propyl]-1H-indazole-6-carboxamide,

(66) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-2-hydroxycyclohexyl]-1H-indazole-6-carboxamide (cis),

(67) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-2-hydroxycyclohexyl]-1H-indazole-6-carboxamide (trans),

(68) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1S)-2-hydroxy-1-methylethyl]-1H-indazole-6-carboxamide,

(69) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-1H-indazole-6-carboxamide,

(70) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[4-(1-hydroxy-1-methylethyl)tetrahydro-2H-pyran-4-yl]-1H-indazole-6-carboxamide,

(71) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[3-hydroxy-3,4-dihydro-2H-chromen-4-yl]-1H-indazole-6-carboxamide,

(72) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-hydroxy-5-methylcyclopentyl]-1H-indazole-6-carboxamide,

(73) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[1-(2,2,2-trifluoro-1-hydroxyethyl)pentyl]-1H-indazole-6-carboxamide,

(74) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-hydroxy-1-(methoxymethyl)-2-phenylethyl]-1H-indazole-6-carboxamide,

(75) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[1-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl]-1H-indazole-6-carboxamide,

(76) tert-butyl 3-({[3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazol-6-yl]carbonyl}amino)-4-hydroxypyrrolidine-1-carboxylate,

(77) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(tetrahydrofuran-3-yl)-1H-indazole-6-carboxamide,

(78) 3-(2-chlorophenyl)-N-(1-cyclopropyl-2-hydroxyethyl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(79) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-hydroxy-1-methylethyl]-1H-indazole-6-carboxamide,

(80) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-hydroxy-1-(hydroxymethyl)-2-phenylethyl]-1H-indazole-6-carboxamide,

(81) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(3,3,3-trifluoro-2-hydroxy-1-methylpropyl)-1H-indazole-6-carboxamide,

(82) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-hydroxy-1-phenylethyl]-1H-indazole-6-carboxamide,

(83) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(3-hydroxycyclopentyl)-1H-indazole-6-carboxamide,

(84) 3-(2-chlorophenyl)-N-cyclopentyl-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(85) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-1H-indazole-6-carboxamide,

(86) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(tetrahydro-2H-pyran-4-yl)-1H-indazole-6-carboxamide,

(87) 3-(2-chlorophenyl)-N-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(88) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[1-(hydroxymethyl)cyclobutyl]-1H-indazole-6-carboxamide,

(89) methyl 3-({[3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazol-6-yl]carbonyl}amino)tetra-hydrothiophene-3-carboxylate 1-oxide,

(90) methyl 3-({[3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazol-6-yl]carbonyl}amino)tetra-hydrothiophene-3-carboxylate 1,1-dioxide,

(91) tert-butyl 6-({[3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazol-6-yl]carbonyl}) amino)-1,4-thiazepane-4-carboxylate 1,1-dioxide,

(92) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[3-(hydroxymethyl)-1,1-dioxidotetrahydrothiophen-3-yl]-1H-indazole-6-carboxamide,

(93) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1S)-1-(hydroxymethyl)-3-(methylsulfanyl)propyl]-1H-indazole-6-carboxamide,

(94) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-hydroxycyclopentyl]-1H-indazole-6-carboxamide,

(95) N-[1-carbamoyl-2-methylpropyl]-3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(96) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[2-hydroxycyclopentyl]-1H-indazole-6-carboxamide,

(97) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1S,2S)-2-hydroxycyclopentyl]-1H-indazole-6-carboxamide,

(98) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[3-(hydroxymethyl)tetrahydrothiophen-3-yl]-1H-indazole-6-carboxamide,

(99) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1S)-1-(hydroxymethyl)-2,2-dimethylpropyl]-1H-indazole-6-carboxamide,

(100) tert-butyl (3 S)-3-({[3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazol-6-yl]carbonyl}amino)pyrrolidine-1-carboxylate,

(101) tert-butyl (3R)-3-({[3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazol-6-yl]carbonyl}amino)pyrrolidine-1-carboxylate,

(102) 3-(2-chlorophenyl)-N-(1,1-dioxido-1,4-thiazepan-6-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(103) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1S,2 S)-1-(hydroxymethyl)-2-methylbutyl]-1H-indazole-6-carboxamide,

(104) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(3-oxocyclobutyl)-1H-indazole-6-carboxamide,

(105) 3-(2-chlorophenyl)-N-(1-cyanocyclopropyl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(106) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]-1H-indazole-6-carboxamide,

(107) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1R,2R)-2-hydroxy-1-methyl-2-phenylethyl]-1H-indazole-6-carboxamide,

(108) N-[1-(4-bromophenyl)-3-hydroxycyclobutyl]-3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(109) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(3-morpholin-4-yl-1-phenylpropyl)-1H-indazole-6-carboxamide,

(110) N-[(1S)-1-benzyl-2-hydroxyethyl]-3-(2-chlorophenyl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(111) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-((2S,3 S,4S,6S)-3-hydroxy-6-methoxy-2-methyltetrahydro-2H-pyran-4-yl)-1H-indazole-6-carboxamide,

(112) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(1-methyl-2-pyridin-2-ylethyl)-1H-indazole-6-carboxamide,

(113) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-(3-hydroxy-1,1-dimethylbutyl)-1H-indazole-6-carboxamide,

(114) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1-hydroxycyclopropyl)methyl]-1H-indazole-6-carboxamide,

(115) 3-(2-chlorophenyl)-1-(4-fluorophenyl)-N-[(1R,2S)-2-hydroxycyclopentyl]-1H-indazole-6-carboxamide,

(167) 1-Benzyl-3-(2-chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(168) 1-(4-chlorobenzyl)-3-(2-chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(169) 3-(2-chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(1-methylethyl)-1H-indazole-6-carboxamide,

(170) 3-(2-chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorobenzyl)-1H-indazole-6-carboxamide,

(171) 3-(2-chlorophenyl)-1-(5-chloropyridin-2-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(172) 3-(2-chlorophenyl)-1-(5-fluoropyridin-2-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(173) 3-(2-chlorophenyl)-1-(5-chloropyridin-2-yl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(174) 3-(2-chlorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1-pyridin-2-yl-1H-indazole-6-carboxamide,

(175) 3-(2-chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-pyridin-2-yl-1H-indazole-6-carboxamide,

(176) 3-(2-chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(5-fluoropyridin-2-yl)-1H-indazole-6-carboxamide,

(179) 3-(2-Chlorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1-(thiazol-4-yl)-1H-indazole-6-carboxamide,

(180) methyl 3-{3-(2-chlorophenyl)-6-[(3-methyl-1,1-dioxidotetrahydrodioxidotetrahydrodioxidotetrahydrodioxidotetrahydro-thiophen-3-yl)carbamoyl]-1H-indazol-1-yl}benzoate,

(181) 3-(2-chlorophenyl)-1-(5-fluoropyrimidin-2-yl)-N-(3-methyl-1,1-dioxidotetradioxidotetradioxidotetradioxidotetra-hydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(182) 3-(2-chlorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1H-indazole-6-carboxamide,

(183) 1-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-3-(2-chlorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(184) 3-(2-chlorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1-(1-methyl-1H-pyrazol-3-yl)-1H-indazole-6-carboxamide,

(185) 3-(2-chlorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1-(5-methylpyridin-2-yl)-1H-indazole-6-carboxamide,

(186) 3-(2-chlorophenyl)-1-(6-methoxypyridin-2-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(187) methyl 4-{3-(2-chlorophenyl)-6-[(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)carbamoyl]-1H-indazol-1-yl}benzoate,

(188) ethyl 2-{3-(2-chlorophenyl)-6-[(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)carbamoyl]-1H-indazol-1-yl}-1,3-oxazole-4-carboxylate,

(189) 3-(2-chlorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1-pyridin-3-yl-1H-indazole-6-carboxamide,

(190) 3-(2-chlorophenyl)-1-(5-cyclopropyl-1,3,4-thiadiazol-2-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide, and

(191) 3-(2-Chlorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-6-carboxamide,

or a pharmaceutically acceptable salt thereof.

6. A compound of claim 1 , selected from the group consisting of

(116) 3-(3-cyanophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(117) 3-(3-cyanophenyl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(118) 3-(2-chloro-5-cyanophenyl)-1-(4-fluorophenyl)-N-[1-(hydroxymethyl)cyclobutyl]-1H-indazole-6-carboxamide,

(119) 3-(2-chloro-5-cyanophenyl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(120) 3-(2-chloro-5-cyanophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(121) 3-(5-carbamoyl-2-chlorophenyl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(122) 3-(5-carbamoyl-2-chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(123) 3-(2-chloro-5-cyanophenyl)-1-(4-fluorophenyl)-N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-1H-indazole-6-carboxamide,

(124) 3-(3-cyclopropylphenyl)-1-(5-fluoropyridin-2-yl)-N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-1H-indazole-6-carboxamide,

(125) 3-(3-cyclopropylphenyl)-1-(5-fluoropyridin-2-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(126) 3-(3-cyclopropylphenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(5-fluoropyridin-2-yl)-1H-indazole-6-carboxamide,

(127) 3-(2-chloro-5-cyanophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(5-fluoropyridin-2-yl)-1H-indazole-6-carboxamide,

(128) 3-[3-(difluoromethoxy)phenyl]-1-(5-fluoropyridin-2-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(129) 3-(3-Cyanophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(130) 3-(2,3-dichlorophenyl)-N-(1,1-dioxidotetrahydro-thiophen-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(131) N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-3-(3-methoxyphenyl)-1H-indazole-6-carboxamide,

(132) 3-(2,6-difluorophenyl)-N-(1,1-dioxidotetrahydro-thiophen-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(133) N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-3-pyrimidin-5-yl-1H-indazole-6-carboxamide,

(134) N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-3-pyridin-3-yl-1H-indazole-6-carboxamide,

(135) 3-(2-chloropyridin-3-yl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(136) 3-[3-(difluoromethoxy)phenyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(137) 3-(5-chloro-2-methoxypyridin-4-yl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(138) 3-(5-chloro-2-methoxypyridin-3-yl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(4-fluorophenyl)-1H-indazole-6-carboxamide,

(139) 3-(1,3-benzodioxol-5-yl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(140) 1-(4-fluorophenyl)-3-(2-methoxypyridin-4-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(141) 3-(5-chloro-2-methoxypyridin-4-yl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(142) 3-(5-chloro-2-methoxypyridin-3-yl)-1H-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(143) 3-[3-(difluoromethoxy)phenyl]-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(144) 1-(4-fluorophenyl)-3-(3-methoxyphenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(145) 3-(3-cyclopropylphenyl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(146) 3-(5-cyanopyridin-3-yl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(147) 1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-[3-(2,2,2-trifluoroethoxy)phenyl]-1H-indazole-6-carboxamide,

(148) 3-[3-(dimethylcarbamoyl)phenyl]-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(149) 3-(3-carbamoylphenyl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(150) 1-(4-fluorophenyl)-3-[3-(1-hydroxy-1-methylethyl)phenyl]-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(151) 3-(5-cyano-2-fluorophenyl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(152) 3-(6-chloro-2-fluoropyridin-3-yl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(153) 1-(4-fluorophenyl)-3-(5-fluoropyridin-3-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(154) 1-(4-fluorophenyl)-3-(2-fluoropyridin-3-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(155) 1-(4-fluorophenyl)-3-(6-methoxypyridin-3-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(156) 1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-(3-methylphenyl)-1H-indazole-6-carboxamide,

(157) 3-(3,5-dichlorophenyl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(158) 3-(3-chlorophenyl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(159) 1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-[2-(trifluoromethyl)pyridin-4-yl]-1H-indazole-6-carboxamide,

(160) 3-[2-chloro-5-(trifluoromethyl)phenyl]-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(161) 3-(5-cyano-2-fluoro-3-methoxyphenyl)-1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(162) 1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-phenyl-1H-indazole-6-carboxamide,

(163) 1-(4-fluorophenyl)-3-(1-methyl-1H-benzotriazol-6-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

(164) 1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-[3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]-1H-indazole-6-carboxamide,

(165) 1-(4-fluorophenyl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-3-[3-(1H-pyrazol-1-yl)phenyl]-1H-indazole-6-carboxamide,

(166) 3-(6-((1,1-dioxidotetrahydrothiophen-3-yl)carbamoyl)-1-(4-fluorophenyl)-1H-indazol-3-yl)pyridine 1-oxide,

(177) 3-(3-cyanophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-1-(5-fluoropyridin-2-yl)-1H-indazole-6-carboxamide, and

(178) -(3-cyanophenyl)-1-(5-fluoropyridin-2-yl)-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1H-indazole-6-carboxamide,

or a pharmaceutically acceptable salt thereof.

7. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

8. A method of treating atherosclerosis, hepatic steatosis, atherosclerosis, type-2 diabetes mellitus, obesity, hyperlipidemia, non-alcoholic steatohepatitis or hypercholesterolemia in a patient in need of treatment comprising the administration to the patient of a therapeutically effective amount of a compound having the structural Formula I′,

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is

(1) 6-membered aryl unsubstituted or substituted by 1-3 R 5 , or

(2) 5-, 6- or 9-membered heteroaryl or 9-membered bicyclic heterocycle, containing 1, 2 or 3 heteroatoms independently selected from N, O, and S, wherein the heteroaryl is unsubstituted or substituted by 1-3 R 5 ;

R 2 is

(1) 6-membered aryl unsubstituted or substituted by 1-3 R 7 ,

(2) 5- or 6-membered heteroaryl containing 1, 2 or 3 heteroatoms independently selected from N, O, and S, wherein the heteroaryl is unsubstituted or substituted by 1-3 R 7 ,

(3) (C 1-6 )alkyl,

(4) 4- to 6-membered heterocyclyl containing 1 or 2 heteroatoms independently selected from N, O and S, or

(5) —CH 2-6 -membered aryl, wherein the aryl is unsubstituted or substituted by 1-3 R 7 ;

R 3 is

(1) 4- to 7-membered heterocyclyl containing 1 or 2 heteroatoms independently selected from N, O and S,

(2) 5- or 6-membered heteroaryl containing 1, 2 or 3 heteroatoms independently selected from N, O, and S,

(3) —(C 1-6 )alkyl-heteroaryl, wherein the heteroaryl is a 5- or 6-membered heteroaryl containing 1, 2 or 3 heteroatoms independently selected from N, O and S,

(4) —(C 1-6 )alkyl-6-membered aryl,

(5) —(C 1-6 )alkyl-heterocyclyl, wherein the heterocyclyl is a 3- to 6-membered ring containing 1 or 2 heteroatoms independently selected from N, O and S,

(6) (C 1-6 )alkyl,

(7) —(C 1-6 )alkyl-C(O)O—(C 1-4 )alkyl,

(8) —(C 1-6 )alkyl-S(O) 2 —NR 9a R 9b ,

(9) —(C 1-6 )alkyl-S(O) 2 —(C 1-3 )alkyl,

(10) —(C 1-3 )alkyl-heteroaryl, wherein the heteroaryl is a 8- to 10-membered fused ring, and wherein the heteroaryl contains 1, 2, 3, or 4 heteroatoms independently selected from N, O, and S,

(11) —(C 1-6 )alkyl-S(O) 2 —(C 3-6 )cycloalkyl,

(12) —(C 1-6 )alkyl-S(O) 2 —NR 9a —(C 3-6 )cycloalkyl,

(13) —(C 1-6 )alkyl-(C 3-6 )cycloalkyl,

(14) (C 3-6 )cycloalkyl, or

(15) 9- to 10-membered fused aryl,

wherein each aryl, heteroaryl, cycloalkyl, or heterocyclyl are unsubstituted or substituted by 1-3 R 6 , and wherein each alkyl is unsubstituted or substituted by 1-3 R 8 ;

R 4 is

(1) hydrogen,

(2) (C 1-3 )alkyl,

or R 3 and R 4 combine along with the nitrogen atom to which they are attached to form a 4- to 7-membered mono- or 6- to 10-membered bicyclic heterocyclyl ring containing 1 or 2 heteroatoms independently selected from N, O and S, wherein the heterocyclyl ring is unsubstituted or substituted by 1-3 R 6 ;

R 5 is

(1) cyano,

(2) halo,

(3) (C 1-6 )alkyl,

(4) —C(O)NH 2 ,

(5) —C(O)NR 10a R 10b ,

(6) (C 3-6 )cycloalkyl,

(7) hydroxy,

(8) hydroxy(C 1-3 )alkyl-,

(9) (C 1-6 )alkoxy-,

(10)-NR 10a R 10b

(11) 5-membered heteroaryl containing 1, 2 or 3 heteroatoms independently selected from N, O, and S, wherein the heteroaryl is unsubstituted or substituted by 1-2 R 7 ;

(12) halo(C 1-6 )alkyl-, or

(13) halo(C 1-6 )alkoxy-;

R 6 is

(1) (C 1-3 )alkyl,

(2) halo(C 1-3 )alkyl-,

(3) oxo,

(4) (C 3-6 )cycloalkyl,

(5) —C(O)O—(C 1-4 )alkyl,

(6) NH 2 ,

(7) hydroxy,

(8) phenyl unsubstituted or substituted by halo,

(9) hydroxy(C 1-3 )alkyl-,

(10) (C 1-6 )alkoxy-,

(11) halo(C 1-6 )alkoxy-,

(12) cyano, or

(13) halo;

R 7 is

(1) (C 1-6 )alkyl,

(2) halo,

(3) (C 1-3 )alkoxy-,

(4) halo(C 1-3 )alkyl-,

(5) (C 3-6 )cycloalkyl, or

(6) —C(O)O—(C 1-3 )alkyl;

R 8 is

(1) (C 1-3 )alkyl,

(2) hydroxy(C 1-3 )alkyl-,

(3) (C 1-3 )alkoxy-,

(4) hydroxy,

(5) halo(C 1-3 )alkyl-,

(6) (C 1-3 )alkyl-S—,

(7) —C(O)—NR 9a R 9b , or

(8) phenyl;

R 9a and R 9b are independently

(1) hydrogen,

(2) (C 1-3 )alkyl,

(3) —(C 1-3 )alkyl-phenyl,

(4) 5- or 6-membered heteroaryl containing 1, 2, or 3 heteroatoms independently selected from N, O, and S, or

(5) phenyl;

R 10a and R 10b are independently

(1) hydrogen, or

(2) (C 1-3 )alkyl.

9. The method according to claim 8 for treating non-alcoholic steatohepatitis.