Peptides for angiogenic therapy
View Patent ↗Provided herein are compositions including peptide or nucleic acids encoding peptides and related methods for the treatment of angiogenic conditions such as cancer, vascular disorders such as cardiovascular disorders, and infectious disease.
1. A composition comprising a viral vector comprising a nucleotide sequence encoding a peptide at least 85% identical to any one of peptides according to SEQ ID NOs: 1-5, 7, 9, or 11, wherein said encoded peptide reduces angiogenesis or induces apoptosis.
2. The composition of claim 1 , wherein the viral vector is a lentivirus vector or an adenovirus vector.
3. The composition of claim 1 , wherein the viral vector is a virus.
4. The composition of claim 1 further comprising a chemotherapeutic agent.
5. The composition of claim 4 wherein the chemotherapeutic agent is cyclophosphamide, doxorubicin, methotrexate, 5-fluorouracil, paclitaxel, docetaxel, navelbine, capecitabine, mitomycin C, prednisone, a taxane, vinblastine, or tamoxifen.
6. The composition of claim 4 wherein the chemotherapeutic agent is an aromatase inhibitor, a proteinase inhibitor, an integrin inhibitor, a VEGF inhibitor, or a collagen-binding antibody.
7. The composition of claim 1 further comprising an anti-angiogenic agent.
8. The composition of claim 7 wherein the anti-angiogenic agent is a growth factor, a cytokine, a protease, a protease inhibitor, an integrin, an antibody, or a glycosidase.
9. The composition of claim 8 wherein the growth factor is ANG-2, NK1, NK2, NK4, Hepatocyte Growth Factor (HGF), or transforming growth factor beta (TGF-β).
10. The composition of claim 8 wherein the cytokine is interferon alpha (IFN-α), interferon beta (IFN-β), interferon gamma (IFN γ), platelet factor 4 (PF-4) or PR-39.
11. The composition of claim 8 wherein the protease cleaves AT-III, collagen XVIII fragment (Endostatin), HmwKallikrein-d5 plasmin fragment (Angiostatin), prothrombin-F1-2, or Thrombospondin-1(TSP-1).
12. The composition of claim 8 wherein the protease inhibitor is tissue inhibitor of metalloprotease 1 (TIMP-1), tissue inhibitor of metalloprotease (TIMP-2), tissue inhibitor of metalloprotease (TIMP-3); plasminogen activator-inhibitor 1 (PAI-1), pigment epithelium derived factor (PEDF), or maspin (mammary serine protease inhibitor).
13. The composition of claim 8 wherein the antibody is HUIV26, HU177, or XL313.
14. The composition of claim 8 wherein the glycosidase is heparinase-I or heparinase-II.