Automatic analyzer and automatic analysis method
Provided is a technique related to an automatic analyzer and capable of ensuring cleaning performance of a reaction container by a cleaning process including a tip suction step, and preventing decrease in analysis accuracy or improving the analysis accuracy. The automatic analyzer includes a control apparatus, a block suction mechanism that moves a suction nozzle and a suction block for suctioning a liquid in the reaction container up and down and suctions the liquid, and a block cleaning mechanism for cleaning the suction block. After receiving an analysis request, the control apparatus causes, in a tip suction step that is provided before an analysis step and is a last step of a cleaning step, both suction of the liquid by the block suction mechanism and cleaning of the suction block by the block cleaning mechanism to be performed in a first step, and then only the suction of the liquid by the block suction mechanism to be performed in a second step including one or more cycles; and causes the analysis step to be performed using the reaction container in which the second step is performed.
1. An automatic analyzer that has a function of performing optical measurement on a reaction solution which contains a sample and a reagent in a reaction container and cleaning of the reaction container, the automatic analyzer comprising:
a disk mechanism on which a plurality of reaction containers are circumferentially disposed, the disk mechanism configured to control a rotation operation of the reaction containers;
a control apparatus configured to control a sequence which includes the optical measurement and the cleaning;
a block suction mechanism that includes a suction nozzle configured to suction a liquid in the reaction container and a suction block attached to a lower end in a vertical direction of the suction nozzle, the block suction mechanism configured to move the suction nozzle and the suction block up and down in the vertical direction, and suction the liquid; and
a block cleaning mechanism that configured to clean the suction block, wherein
the block cleaning mechanism includes the block suction mechanism, which further includes a discharge nozzle configured to discharge a cleaning liquid to an upper surface of the suction block,
the block suction mechanism and the block cleaning mechanism, during the cleaning of the reaction container, are disposed on predetermined positions on a circumference of the disk mechanism, and
after receiving a start request of the optical measurement, the control apparatus is configured to:
cause, in the step of the cleaning of the reaction container that is provided before a step of the optical measurement and includes a plurality of cycles in which a unit movement of the disc mechanism is set as one cycle, both cleaning of the suction block by the block cleaning mechanism and suction of the liquid by the block suction mechanism to be performed in a first step that includes a plurality of cycles, and only the suction of the liquid by the block suction mechanism to be performed in a second step that includes one or more cycles, and
cause the first optical measurement to be performed by using the reaction container in which the second step is performed.
2. The automatic analyzer according to claim 1 , wherein
the discharge nozzle is connected to the suction nozzle, and a lower end in the vertical direction of the discharge nozzle is disposed at a position higher than the upper surface of the suction block.
3. The automatic analyzer according to claim 1 , wherein
a height in the vertical direction of the suction block is equal to or less than a half of a height of an inner wall of the reaction container.
4. The automatic analyzer according to claim 1 , wherein
the block cleaning mechanism includes a mechanism configured to move the suction block up and down in the vertical direction and immerse the suction block in a cleaning liquid in the reaction container, and
the block cleaning mechanism is configured to move the suction block up and down in the vertical direction and immerse the suction block in the cleaning liquid in the reaction container, so that the control apparatus controls the step of the cleaning in the first step.
5. The automatic analyzer according to claim 1 , wherein
the control apparatus is configured to cause the suction nozzle and the suction block to descend or ascend in the vertical direction at a second speed faster than a first speed during a normal operation in one or more cycles of the second step.
6. The automatic analyzer according to claim 1 , wherein
the control apparatus is configured to cause the suction nozzle and the suction block to vibrate to left and right in a horizontal direction in one or more cycles of the second step.
7. The automatic analyzer according to claim 1 , wherein
the control apparatus is configured to cause a suction pressure of the suction nozzle and the suction block to increase to a second suction pressure higher than a first suction pressure during a normal operation in one or more cycles of the second step.
8. An automatic analysis method in an automatic analyzer,
the automatic analyzer having a function of performing optical measurement on a reaction solution which contains a sample and a reagent in a reaction container and cleaning of the reaction container, the automatic analyzer including:
a disk mechanism on which a plurality of reaction containers are circumferentially disposed, the disk mechanism configured to control a rotation operation of the reaction containers;
a control apparatus configured to control a sequence which includes the optical measurement and the cleaning;
a block suction mechanism that includes a suction nozzle configured to suction a liquid in the reaction container and a suction block attached to a lower end in a vertical direction of the suction nozzle, the block suction mechanism configured to move the suction nozzle and the suction block up and down in the vertical direction, and suction the liquid; and
a block cleaning mechanism configured to clean the suction block, the block cleaning mechanism including the block suction mechanism, which further includes a discharge nozzle configured to discharge a cleaning liquid to an upper surface of the suction block,
the block suction mechanism and the block cleaning mechanism, during the cleaning of the reaction container, being disposed on predetermined positions on a circumference of the disk mechanism,
the method comprising:
a step of causing both cleaning of the suction block by the block cleaning mechanism and suction of the liquid by the block suction mechanism to be performed in a first step that includes a plurality of cycles, and a step of causing only the suction of the liquid by the block suction mechanism to be performed in a second step that includes one or more cycles, by the control apparatus after receiving a start request of the optical measurement, the two steps being included in the step of the cleaning of the reaction container that includes a plurality of cycles in which a unit movement of the disc mechanism is set as one cycle, and
a step of causing the first optical measurement to be performed by using the reaction container in which the second step is performed.
9. The automatic analyzer according to claim 1 , wherein
the block suction mechanism is configured to move the suction nozzle and the suction block into a stationary position in the reaction container in which gaps of predetermined lengths between side surfaces of the suction block and the reaction container and between bottom surfaces of the suction block and the reaction container, and to suction the liquid in the reaction container with the suction nozzle and the suction block in the stationary position.