IP Library › Granted Patent US 10,874,631
Granted Patent B2
US 10,874,631 · App. 16/471,905 · Granted Dec 29, 2020

Altertoxin II as a selective inhibitor of Ewing family of tumor cells

Inventors: Susan L Mooberry (Austin, TX); Andrew J Robles (Austin, TX); April L Risinger (Austin, TX); Robert H Cichewicz (Norman, OK); Saikat Haldar (Norman, OK); Peter Houghton (Austin, TX)
Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
A61K31/336A61K9/0019A61P35/00
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Quick Facts
Patent No.
US 10,874,631
App. No.
16/471,905
Granted
Dec 29, 2020
Kind
B2
Abstract

Certain embodiments are directed to methods for treating Ewing family tumors (EFT) comprising administering an effective amount of altertoxin II to a subject having EFT.

Claims (10)

1. A method for treating a Ewing sarcoma family tumor (EFT) comprising administering an effective amount of altertoxin II to a subject having a EFT.

2. The method of claim 1 , wherein the altertoxin II is a pharmaceutically acceptable salt.

3. The method of claim 1 , wherein the subject is a human subject.

4. The method of claim 3 , wherein the human subject is a pediatric subject.

5. The method of claim 1 , wherein the effective amount of altertoxin II is between 1 mg and 500 mg.

6. The method of claim 1 , further comprising administering a chemotherapy, radiotherapy, or immunotherapy.

7. The method of claim 1 , wherein the EFT is a Ewing sarcoma.

8. The method of claim 1 , wherein altertoxin II is administer orally or by injection.

9. The method of claim 8 , wherein administering by injection is by intravenous injection.

10. The method of claim 8 , wherein administering by injection is by local injection.

Assignments (3)
CONFIRMATORY LICENSE Recorded Aug 11, 2023
From: UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANTONIO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 064572/0226 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 20, 2019
From: CICHEWICZ, ROBERT H; HALDAR, SAIKAT
To: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
Reel/Frame 049540/0088 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 20, 2019
From: MOOBERRY, SUSAN L; RISINGER, APRIL L; ROBLES, ANDREW J
To: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 049540/0600 →
Continuity (2)
Provisional Application 62437333 · Dec 21, 2016
Related Publication 20200101038A1 · Apr 2, 2020